APPENDICES. A systematic review and economic model of the ...

284
Appendix 12
Core symptoms Educational performance Quality of life Adverse events
STESS (investigator)
% of parents and patients reporting side-effects for
MPH/PLA:
Abbreviated Conners’ Questionnaire
(parents): Mean (SD) scores at week 3:
PLA: 1.33 (0.76)
MPH: 0.87 (0.60)
Analyses including 3 weekly scores:
F(1,17) = 6.52, p < 0.03
Parents Patients
Eat less 10.5/10.5 10.5/ 31.6
Eat more 5.3/10.5 0.0/5.3
Drink more 11.8/5.9 11.1/16.7
Drink less 0.0/0.0 0.0/5.3
Dry mouth 0.0/0.0 10.5/5.3
Wet mouth 0.0/0.0 0.0/0.0
Stomach ache 0.0/0.0 5.3/5.3
Nausea 5.3/0.0 0.0/0.0
Rashes 0.0/0.0 0.0/0.0
Headaches 0.0/15.8 0.0/0.0
Dizziness 0.0/0.0 0.0/0.0
Shakiness 5.3/0.0 0.0/0.0
Pronunciation 0.0/0.0 0.0/0.0
Clumsiness 5.3/0.0 0.0/0.0
Restlessness 62.5/62.5 17.6/23.5
Fatigue 11.1/16.7 15.8/26.3
Sleepiness 11.8/11.8 10.5/26.3
Sleep problem 26.3/15.8 15.8/21.1
Crying 5.3/0.0 0.0/5.3
Irritability 47.4/42.1 5.6/16.7
Unhappiness 15.8/26.3 10.5/15.8
Sadness 10.5/ 15.8 0.0/21.1
Not reported Loney and Ordona Scale: response (patients,
parents)
End of trial (blinded) statement which phase
yielded better results and outcomes rating in
comparison with no medication
[7 = dramatic response; 0 = no change at
all; –3 = dramatically bad response
(preferred placebo)] for parent/patient:
7 = Dramatic response 10.5/0.0
6 = Total improvement 10.5/10.5
5 = Good response 0.0/15.6
4 = General improvement 31.6/10.5
3 = Some consistent
improvement 5.3/0.0
2 = Mixed or variable response 10.5/15.6
1 = Unimpressive response 0.0/15.6
0 = No change at all 15.6/31.6
–1 = No change except
side-effects 5.3/0/0
–2 = Bad response 0.0/0.0
–3 = Dramatically bad response 10.5/0.0
No significant difference between parent and
child ratings; average of parents’ and
children’s ratings compared with expected
value of 0 = no change: F(1,17) = 20.89,
p < 0.0003
Abbreviated Conners’ Questionnaire
(teachers)
PLA: 0.64 (0.52)
MPH: 0.50 (0.46)
No significant difference
Loney and Milich’s
Inattention/Overactivity scale (parents)
MPH: 1.26 (0.69)
PLA: 0.88 (0.69)
Analyses including 3 weekly scores:
F(1,17) = 4.88, p < 0.05
Loney and Milich’s Aggression (noncompliance)
scale (parents)
MPH: 1.34 (0.80)
PLA: 0.92 (0.56)
No significant difference: F(1,17) = 3.36,
p < 0.09.
Patient: t(18) = 2.19, p < 0.05
Inattention 26.7/26.7 5.6/5.6
Loney and Milich’s
Inattention/Overactivity scale (teachers)
MPH: 0.82 (0.66)
PLA: 0.64 (0.60)
At week 3: t(26) = 2.06, p < 0.02
Loney and Milich’s Aggression (noncompliance)
scale (teachers)
MPH: 0.29 (0.35)
PLA: 0.16 (0.24)
At week 3: t(26) = 2.52, p < 0.02
Conclusions Authors’ conclusions: The authors conclude that stimulant therapy is a useful approach in the management of ADD in adolescents
Reviewer’s comments: No comments noted