APPENDICES. A systematic review and economic model of the ...

Core symptoms Educational performance Quality of life Adverse events
Hillside Behaviour Scale: interest in tasks (teachers). Adjusted mean
(SD) factor scores before/after treatment (12 weeks)
Arm 1: 3.2 (1.0)/2.2 (0.7), n = 25
Arm 2: 3.1 (0.8)/2.1 (0.8), n = 23
Arm 3: 3.0 (0.6)/2.9 (0.9), n = 25
MPH > BT (t = 3.07, p = 0.01); comb > BT (t = 3.24, p = 0.006);
MPH vs comb (not significant)
Hillside Behaviour Scale: impulse control (teachers). Adjusted mean
(SD) factor scores before/after treatment (12 weeks)
Arm 1: 4.5 (0.9)/2.8 (0.8), n = 25
Arm 2: 4.4 (0.8)/2.1 (0.6), n = 23
Arm 3: 4.2 (1.0)/3.6 (1.0), n = 25
MPH > BT (t = 3.08, p = 0.01); comb > MPH (t = 3.42,
p = 0.003); comb > BT (6.27, p = 0.0001)
Hillside Behaviour Scale: gross motor activity (teachers). Adjusted
mean (SD) factor scores before/after treatment (12 weeks)
Arm 1: 5.1 (1.2)/2.2 (1.2), n = 25
Arm 2: 4.8 (1.3)/1.6 (0.8), n = 23
Arm 3: 4.8 (1.4)/3.4 (1.7), n = 25
MPH > BT (t = 3.08, p = 0.01); comb > BT (t = 4.69,
p = 0.0001), MPH vs comb (not significant)
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Health Technology Assessment 2006; Vol. 10: No. 23
Home Hyperactivity Scale (parents). Adjusted mean (SD) scale
scores before/after treatment (12 weeks)
Arm 1: 3.7 (0.87)/2.1 (0.46), n = 29
Arm 2: 3.6 (0.87)/1.8 (0.51), n = 28
Arm 3: 3.4 (0.75)/2.4 (0.86), n = 28
No significant differences
Overall Severity Index (blinded observers). Adjusted mean (SD)
ratings before/after treatment (12 weeks)
Arm 1: 1.9 (0.6)/1.0 (0.8), n = 28
Arm 2: 2.0 (0.5)/0.7 (0.7), n = 29
Arm 3: 2.0 (0.6)/1.9 (0.8), n = 28
MPH > BT (t = 4.42, p = 0.0001); comb > BT (t = 5.59,
p = 0.0001); MPH vs comb (not significant)
Hillside Behaviour Scale: concentration, interest in tasks, impulse
control and gross motor activity (parents, psychologists, blinded
observers)
Children’s Psychiatric Rating Scale: fidgetiness, hyperactivity and
distractibility
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