APPENDICES. A systematic review and economic model of the ...

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264 Appendix 12 Core symptoms Educational performance Quality of life Adverse events No child treated with placebo or MPH had severe side-effects. See Additional information above for information on withdrawals due to side-effects Conclusions Authors’ conclusions: Significant clinical improvement was obtained in a variety of settings – all treatments were superior to placebo on ratings filled out by parents, teacher and clinic staff Reviewer’s comments: No comments noted
Study Intervention Participants Outcomes Core symptoms Not reported Inclusion criteria No explicit inclusion criteria Reference Greenberg et al., 1972 58 Co-existent problems Not reported Diagnostic criteria Diagnostic conference undertaken with staff paediatrician, parents and child Source AHRQ Report Educational performance Not reported Arm 1 DEX Gradual titration using 5-mg capsules administered twice daily (with breakfast and mid-afternoon); dosage increased until side effects necessitated lower dose; mean dosage 25 mg/day during 4–8th weeks (Individuals administering medication not reported) Setting USA Psychological function Not reported Number Total randomised = 76 (male = 76) Numbers by arm not reported Design Parallel trial Depression or anxiety Not reported Total analysed = 61 Arm 1 = 17 Arm 2 = 17 Arm 3 = 17 Arm 4 = 10 Arm 2 Chlorpromazine Gradual titration using 35-mg capsules administered twice daily (with breakfast and mid-afternoon); dosage increased until sideeffects necessitated lower dose; mean dosage 125 mg/day during 4–8th weeks (Individuals administering medication not reported) Duration Treatment period: 8 weeks Quality of life Not reported Adverse events Incidence of side-effects (no specific scale reported) Total withdrawals = 14.4% Age 8.7 years (mean); 6 years 6 months–11 years (range) Additional outcomes Weight IQ Full scale: 85 (mean) Purpose To determine the clinical efficacy of three commonly prescribed medications: chlorpromazine, dextroamphetamine and hydroxyzine, in the treatment of hyperactive children © Queen’s Printer and Controller of HMSO 2006. All rights reserved. Co-morbid disorders Not reported Health Technology Assessment 2006; Vol. 10: No. 23 Diagnostic subtypes Not reported Additional information No relevant information reported Arm 3 Hydroxyzine Gradual titration using 25-mg capsules administered twice daily (with breakfast and mid-afternoon); dosage increased until sideeffects necessitated lower dose; mean dosage 150 mg/day during 4–8th weeks (Individuals administering medication not reported) Arm 4 Placebo Twice daily (with breakfast and mid-afternoon) (Individuals administering medication not reported) 265
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180 Appendix 6 Cost-effectiveness R
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182 Appendix 7 Appropriateness of m
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184 Appendix 7 Sensitivity analysis
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186 Appendix 7 Sensitivity analysis
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188 Appendix 8 Probability cost-eff
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202 Appendix 12 Study Intervention
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366 Appendix 13 Study characteristi
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