APPENDICES. A systematic review and economic model of the ...

Study Intervention Participants Outcomes
Core symptoms
CPRS-R: impulsive-hyperactive factor and
composite hyperactivity index
CTRS-R: hyperactivity factor,
inattentive–passive factor and hyperactivity
index
Parental Global Perceptions Questionnaire:
concentration, activity
Arm 1
MPH
Gradual build-up to target of
0.3 mg/kg/dose administered after
breakfast and lunch
(Individual administering medication
not reported)
Reference
Efron et al., 1997; 50
Efron et al., 1997; 143
Efron et al., 1997300 and
Efron et al., 1998 301
Source
AHRQ Report
Co-existent problems
CPRS-R: conduct problems
CTRS-R: conduct problems
Inclusion criteria
1. Aged between 5 and 15 years
2. Satisfy DSM-IV criteria for ADHD
3. T score of at least 1.5 SD units above the mean on the
attention problems scale of the CBCL or Teacher Report
Form (TRF)
4. No history of intellectual disability, gross neurological
abnormality or Tourette’s syndrome
5. Decision made to undertake stimulant medication trial on
clinical grounds
Setting
Australia
Diagnostic criteria
DSM-IV
Arm 2
DEX
Gradual build-up to target of
0.15 mg/kg/dose administered after
breakfast and lunch
(Individual administering medication
not reported)
Design
Crossover trial
Educational performance
CPRS-R: learning problems
Psychological function
Continuous Performance Test (CPT)
Number
Total randomised = 125 (male = 114)
No withdrawals reported
Age
104.8 months (mean); 60–179 months (range) 27.6 months (SD)
Duration
Total treatment time:
4 weeks; Treatment
periods: 2 weeks per
treatment arm with
24-hour washout
Depression or anxiety
CPRS-R: anxiety
Quality of life
Parental Global Perceptions Questionnaire:
overall perceptions
Child Global Perceptions Questionnaire
IQ
98.9 (mean)
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Co-morbid disorders
Not reported
Health Technology Assessment 2006; Vol. 10: No. 23
Adverse events
SERS (parents)
Additional outcomes
CPRS-R: psychosomatic
Diagnostic subtypes
ADHD mixed type: 101 (80.8%)
ADHD predominantly inattentive type: 22 (17.6%)
ADHD predominantly hyperactive/impulsive type: 2 (1.6%)
Additional information
No relevant information reported
Purpose
1. To compare MPH
and DEX in a sample
of children with
ADHD
2. To compare the sideeffect
profiles of
MPH and DEX in
children with ADHD
and to determine
which symptoms are
genuine adverse
effects of stimulant
medication, as
opposed to aspects
of the child’s
underlying behaviour
phenotype
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