APPENDICES. A systematic review and economic model of the ...

More documents

Recommendations

Info

212 Appendix 12 Core symptoms Educational performance Quality of life Adverse events Weight: mean (SD) Placebo: 70.6 lb (18) DEX: 68.1 lb (18) Efamol: 69.5 lb (19) DEX < placebo, p < 0.05 Not reported Global ratings (psychiatrist) (SD not reported) Placebo: 3.78 DEX: 2.67 Efamol: 3.17 DEX > placebo, p < 0.05 Conners’ Teacher Rating Scale: total score (mean, SD) Placebo: 1.59 (0.39) DEX: 1.11 (0.57) Efamol: .39 (0.58) At 4 weeks: DEX > placebo, p < 0.05 Conners’ Teacher Rating Scale: Hyperactivity Index Placebo: 2.10 (0.47) DEX: 1.39 (0.76) Efamol: 1.81 (0.67) At 4 weeks: DEX > Efamol > placebo, p < 0.05 Conclusions Authors’ conclusions: -Linolenic acid supplementation should be considered to be an experimental treatment for ADHD Reviewer’s comments: No comments noted
Study Intervention Participants Outcomes Core symptoms Not reported Reference Barkley et al., 1990 39 Co-existent problems Not reported Source AHRQ Report Educational performance Not reported Arm 1 MPH 0.3 mg/kg/dose; administered twice daily (a.m. and noon) (Individual administering medication not reported) Setting USA Psychological function Not reported Arm 2 MPH 0.5 mg/kg/dose; administered twice daily (a.m. and noon) (Individual administering medication not reported) Design Crossover trial Depression or anxiety Not reported Inclusion criteria 1. IQ > 80 (Peabody Picture Vocabulary) 2. Parental and/or teacher complaints of significant problems with inattention, overactivity and impulsivity 3. Placement at the 93rd percentile on the hyperactivity scales using the Child Behaviour Checklist 4. Appearance of symptoms before age 7 years 5. Symptoms persisting for at least 12 months 6. No gross sensory or motor disabilities, epilepsy, autism, psychosis, tic disorders or Tourette syndrome, or significant cardiac problems Diagnostic criteria See inclusion criteria Duration Treatment periods: 7–10 days Quality of life Not reported Adverse events Stimulant Drug Side Effects Questionnaire: 17-item list Number Total randomised = 83 (male = 71) Total withdrawals = 3 Arm 3 Placebo (Individual administering medication not reported) Additional outcomes Not reported Reasons for withdrawals: 3 children were unable to complete the drug protocol owing to serious adverse reactions. Purpose To assess the frequency and severity of sideeffects associated with two therapeutic doses of MPH in children with ADHD © Queen’s Printer and Controller of HMSO 2006. All rights reserved. Age 8.2 years (mean), 5–13 years (range), 2.2 years (SD) Health Technology Assessment 2006; Vol. 10: No. 23 IQ 105.1 (mean) Co-morbid disorders Not reported Diagnostic subtypes Not reported Additional information No relevant information reported 213
Page 1 and 2:
Appendices A systematic review and
Page 3 and 4:
Clinical effectiveness information
Page 5 and 6:
Searches for systematic reviews in
Page 7 and 8:
19. methyl phenidate.mp. 20. methyl
Page 9 and 10:
43. attention deficit$.mp. 44. 42 o
Page 11 and 12:
MEDLINE in-process and other non-in
Page 13 and 14:
PsycINFO (1967-July 2004) Searched:
Page 15 and 16:
next aminopropane) or dynaphenyl or
Page 17 and 18: or ritaline or riphenidate or rital
Page 19: System for Information on Grey Lite
Page 22 and 23: 166 Appendix 2 S hyperkinetic S imp
Page 24 and 25: 168 Appendix 2 19. (eq5d or eq 5d o
Page 26 and 27: 170 Appendix 2 14. (person trade of
Page 28 and 29: 172 Appendix 3 Reference Reason for
Page 31: Appendix 4 © Queen’s Printer and
Page 34 and 35: 178 Appendix 5 8. Was the statistic
Page 36 and 37: 180 Appendix 6 Cost-effectiveness R
Page 38 and 39: 182 Appendix 7 Appropriateness of m
Page 40 and 41: 184 Appendix 7 Sensitivity analysis
Page 42 and 43: 186 Appendix 7 Sensitivity analysis
Page 44 and 45: 188 Appendix 8 Probability cost-eff
Page 47 and 48: Appendix 10 © Queen’s Printer an
Page 49 and 50: Health state Responder to ATX, no s
Page 51 and 52: Health state Responder to IR-MPH, R
Page 53 and 54: Health state Responder to ER-MPH, R
Page 55: #Baseline shift random effects mode
Page 58 and 59: 202 Appendix 12 Study Intervention
Page 62 and 63: 206 Appendix 12 Core symptoms Educa
Page 118 and 119:
262 Appendix 12 Study Intervention
Page 120 and 121:
264 Appendix 12 Core symptoms Educa
Page 122 and 123:
Page 124 and 125:
Page 126 and 127:
Page 128 and 129:
Page 130 and 131:
Page 132 and 133:
Page 134 and 135:
Page 136 and 137:
Page 138 and 139:
Page 140 and 141:
Page 142 and 143:
Page 144 and 145:
Page 146 and 147:
Page 148 and 149:
Page 150 and 151:
Page 152 and 153:
Page 154 and 155:
Page 156 and 157:
Page 158 and 159:
Page 160 and 161:
Page 162 and 163:
Page 164 and 165:
Page 166 and 167:
Page 168 and 169:
Page 170 and 171:
Page 172 and 173:
Page 174 and 175:
Page 176 and 177:
Page 178 and 179:
Page 180 and 181:
Page 182 and 183:
Page 184 and 185:
Page 186 and 187:
Page 188 and 189:
Page 190 and 191:
Page 192 and 193:
Page 194 and 195:
Page 196 and 197:
Page 198 and 199:
Page 200 and 201:
Page 202 and 203:
Page 204 and 205:
Page 206 and 207:
Page 208 and 209:
Page 210 and 211:
Page 212 and 213:
Page 214 and 215:
Page 216 and 217:
Page 218 and 219:
Page 220 and 221:
Page 222:
366 Appendix 13 Study characteristi
show all

APPENDICES. A systematic review and economic model of the ...

Create successful ePaper yourself

Delete template?

Save as template?