APPENDICES. A systematic review and economic model of the ...

Study Intervention Participants Outcomes
Core symptoms
CTRS: inattentiveness and hyperactivity
Devereux Elementary School Behaviour
Rating Scale
Conners’ Abbreviated Rating Scale (parents)
Devereux Child Behaviour Rating Scale
(parents)
Werry–Weiss–Peters Activity Scale
Inclusion criteria
1. 7–13 years old
2. IQ 80
3. Diagnosis of both ADDH and Developmental Reading
Disorder according to DSM-III criteria
4. No additional Axis I psychiatric diagnosis
5. No uncorrected hearing or visual deficits
Arm 1
Placebo plus non-drug intervention
Placebo administered once daily
One-to-one reading therapy
programme during weeks 3–14 and
16–27: weekly with reading therapist
and 5 days/week at home with parent
(Administered by parent)
Reference
Kupietz et al., 1988 71
Source
AHRQ Report
Setting
USA
Design
Parallel trial
Co-existent problems
CTRS: aggressiveness
Educational performance
Not reported
Arm 2
MPH plus non-drug intervention
0.3 mg/kg/day administered in one
dose for weeks 1–14 and 16–27;
placebo during week 15. One-to-one
reading therapy programme during
weeks 3–14 and 16–27: weekly with
reading therapist and 5 days/week at
home with parent
(Administered by parent)
Duration
Study length: 8 weeks;
total treatment period:
6 months
Psychological function
Paired-Associated Learning task
Short-term Memory task
Diagnostic criteria
DSM-III
Number
Total randomised = 58 (male/female split not reported)
Arm 1 = 16
Arm 2 = 19
Arm 3 = 12
Arm 4 = 11
Depression or anxiety
Not reported
Quality of life
Not reported
Total withdrawals = 11
Arm 1 = 4
Arm 2 = 5
Arm 3 = 1
Arm 4 = 1
Age
116.9 months (mean); 20.1 months (SD)
Purpose
To investigate the
effects of 6-month MPH
treatment on home and
school behaviour and
on cognitive
performance in
hyperactive, readingdisabled
children
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Adverse events
Not reported
Health Technology Assessment 2006; Vol. 10: No. 23
Additional outcomes
Plasma assay using gas chromatography
IQ
93.8 (mean)
Co-morbid disorders
All children received a dual diagnosis of ADDH and
Developmental Reading Disorder
(Reading Grade Level: mean = 2.3, SD = 1.0)
Arm 3
MPH plus non-drug intervention
0.5 mg/kg/day administered in one
dose for weeks 1–14 and 16–27;
placebo during week 15. One-to-one
reading therapy programme during
weeks 3–14 and 16–27: weekly with
reading therapist and 5 days/week at
home with parent
(Administered by parent)
Diagnostic subtypes
Not reported
Additional information
No relevant information reported
Arm 4
MPH plus non-drug intervention
0.7 mg/kg/day administered in one
dose for weeks 1–14 and 16–27;
placebo during week 15. One-to-one
reading therapy programme during
weeks 3–14 and 16–27: weekly with
reading therapist and 5 days/week at
home with parent
(Administered by parent)
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