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238<br />

Appendix 12<br />

Core symptoms Educational performance Quality <strong>of</strong> life Adverse events<br />

Not reported Not reported Physician’s ratings:<br />

Arm 1: 84% well or very well tolerated<br />

Arm 2: 90% well or very well tolerated<br />

Parent ratings:<br />

Arm 1: 88% well or very well tolerated<br />

Arm 2: 90% well or very well tolerated<br />

FBB/HKS: mean (SD)<br />

Week 0: Arm 1: 1.82 (0.49), Arm 2: 1.87 (0.59);<br />

effect size: 0.09<br />

Week 1: Arm 1: 1.25 (0.64), Arm 2: 1.69 (0.59);<br />

effect size: 0.80<br />

Week 2: Arm 1: 1.00 (0.61), Arm 2: 1.66 (0.69);<br />

effect size: 0.98<br />

Week 3: Arm 1: 0.92 (0.58), Arm 2: 1.69 (0.71);<br />

effect size: 1.22<br />

Week 4: Arm 1: 0.85 (0.62), Arm 2: 1.64 (0.69);<br />

effect size: 1.20<br />

5-point effectiveness scale: parents<br />

Missing: Arm 1: n = 1/43; Arm 2: n = 0/42<br />

Very good: Arm 1: n = 10/43; Arm 2: n = 0/42<br />

Good: Arm 1: n = 16/43; Arm 2: n = 2/42<br />

Average: Arm 1: n = 7/43; Arm 2: n = 8/42<br />

Poor: Arm 1: n = 7/43; Arm 2: n = 15/42<br />

Very poor: Arm 1: n = 2/43; Arm 2: n = 17/42<br />

?2 p-value

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