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APPENDICES. A systematic review and economic model of the ...

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Study Intervention Participants Outcomes<br />

Core symptoms<br />

CBCL parent rated<br />

Teacher report form<br />

Inclusion criteria<br />

Diagnosis <strong>of</strong> ADHD<br />

Reference<br />

Tervo et al., 2002 93<br />

Co-existent problems<br />

Not reported<br />

Diagnostic criteria<br />

DSM-IV<br />

Arm 1<br />

Placebo<br />

Twice daily for 6 days<br />

(Individual administering medication<br />

not reported)<br />

Source<br />

Updated search<br />

Educational performance<br />

Not reported<br />

Number<br />

Total r<strong>and</strong>omised = 41 (male/female split not reported)<br />

Total withdrawals unclear<br />

Arm 2<br />

MPH<br />

0.05 mg/kg twice daily for 6 days<br />

(Individual administering medication<br />

not reported)<br />

Setting<br />

USA<br />

Psychological function<br />

Not reported<br />

The authors described withdrawals, but did not present <strong>the</strong>m separately<br />

for children with <strong>and</strong> without ADHD-MD<br />

Design<br />

Crossover trial<br />

Depression or anxiety<br />

Not reported<br />

Age<br />

10 years (mean); 2.86 years (SD)<br />

Quality <strong>of</strong> life<br />

Not reported<br />

Arm 3<br />

MPH<br />

0.3 mg/kg twice daily for 6 days<br />

(Individual administering medication<br />

not reported)<br />

Duration<br />

Total treatment period:<br />

3 weeks (6 days per<br />

treatment arm followed<br />

by a 1-day washout<br />

period)<br />

Adverse events<br />

Not reported<br />

IQ<br />

Not reported<br />

Co-morbid disorders<br />

Children with ADHD-MD were also included in <strong>the</strong> <strong>review</strong>, but data are<br />

not extracted here<br />

Additional outcomes<br />

Not reported<br />

Diagnostic subtypes<br />

Not reported<br />

© Queen’s Printer <strong>and</strong> Controller <strong>of</strong> HMSO 2006. All rights reserved.<br />

Additional information<br />

No relevant information reported<br />

Purpose<br />

To evaluate <strong>the</strong><br />

medication<br />

responsiveness <strong>of</strong><br />

children with ADHD<br />

(with or without motor<br />

dysfunction). Only data<br />

for children without<br />

motor dysfunction<br />

(ADHD-MD) have been<br />

extracted<br />

Health Technology Assessment 2006; Vol. 10: No. 23<br />

351

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