APPENDICES. A systematic review and economic model of the ...

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Appendix 12
Core symptoms Educational performance Quality of life Adverse events
% side-effects: parent report
Appetite loss: placebo = 10.4%, MPH = 27.1%;
2 = 4.00, p < 0.05
Increased thirst: placebo = 4.3%, MPH = 2.1%
Dry mouth: placebo = 2.1%, MPH = 8.3%
Stomach aches: placebo = 6.2%, MPH = 6.2%
Nausea: placebo = 2.1%, MPH = 0.0%
Headaches: placebo = 6.4%, MPH = 12.8%
Sleep problem: placebo: 14.6%, MPH = 16.7%
Shakiness: placebo = 0.0%, MPH = 0.0%
Crying: placebo = 8.5%, MPH = 4.3%
Anger: placebo = 34.8%, MPH = 23.9%
Unhappiness: placebo = 22.9%, MPH = 20.8%
Sadness: placebo = 4.2%, MPH = 4.2%
Not reported % ratings of global outcome:
parent’s/patient’s reports
Dramatic response (score 7):
0.0/4.4%
Total improvement (score 6):
4.2/2.2%
Good response (score 5):
22.9/19.6%
General improvement
(score 4): 22.9/10.9%
Some consistent improvement
(score 3): 2.1/0.0%
Mixed or variable response
(score 2): 10.4/13.0%
Unimpressive response (score
1): 4.2/ 4.4%
No change at all (score 0):
10.4/30.4%
Dramatically bad response:
(score –3): 22.9/15.2%
Results presented in figures for majority of
outcomes
Child Psychiatric Scale mean ± SD ratings:
Pretrial = 0.10 ± 0.15,
Placebo = 0.12 ± 0.16, MPH = 0.06 ± 0.06
MPH was significantly superior to placebo:
F(1,44) = 8.66, p < 0.006
% side-effects: patient report
Appetite loss: placebo =6.4%, MPH = 29.8%;
2 = 8.07, p < 0.01
Increased thirst: placebo = 8.7%, MPH = 13.0%
Dry mouth: placebo = 8.5%, MPH = 19.1%,
2 = 3.57, p < 0.10
Stomach aches: placebo = 4.3%, MPH = 8.5%
Nausea: placebo = 2.1%, MPH = 2.1%
Headaches: placebo = 4.3%, MPH = 6.4%
Sleep problem: placebo = 12.8%, MPH = 17.0%
Shakiness: placebo = 2.1%, MPH = 8.5%, 2 = 3.00,
p < 0.10
Crying: placebo = 0.0%, MPH = 6.4%
Anger: placebo = 17.4%, MPH = 10.9%
Unhappiness: placebo = 12.8%, MPH = 10.6%
Sadness: placebo = 0.0%, MPH = 4.3%
Ratings by parents and
patients were similar:
F(1,44)