APPENDICES. A systematic review and economic model of the ...

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364 Appendix 12 Core symptoms Educational performance Quality of life Adverse events Not reported Not adequately presented data by drug (Results for whole sample, i.e. including comorbid patients) Reading scores: mean (SD) (no. of subjects) Arm 1: Baseline: 96.1 (13.7) (144); 14-month follow-up: 97.9 (14.1) (124) Arm 2: Baseline: 96.2 (14.9) (134); 14-month follow-up: 96.2 (14.9) (134) Arm 3: Baseline: 96.5 (14.6) (145); 14-month follow-up: 99.4 (15.2) (136) Arm 4: Baseline: 95.5 (14.3) (146); 14-month follow-up: 95.4 (14.2) (131) (Results for whole sample, i.e. including co-morbid patients) Inattention: teacher rating: mean (SD) (no. of subjects) Arm 1: Baseline: 2.27 (0.61) (135); 14-month follow-up: 1.11 (0.77) (120) Arm 2: Baseline: 2.28 (0.64) (136); 14-month follow-up: 1.47 (0.81) (119) Arm 3: Baseline: 2.16 (0.67) (137); 14-month follow-up: 1.12 (0.75) (134) Arm 4: Baseline: 2.19 (0.69) (135); 14-month follow-up: 1.48 (0.82) (128) Inattention: parent rating: mean (SD) (no. of subjects) Arm 1: Baseline: 2.03 (0.64) (140); 14-month follow-up: 1.12 (0.70) (121) Arm 2: Baseline: 1.99 (0.63) (139); 14-month follow-up: 1.40 (0.68) (129) Arm 3: Baseline: 2.07 (0.61) (140); 14-month follow-up: 1.02 (0.66) (133) Arm 4: Baseline: 2.05 (0.65) (142); 14-month follow-up: 1.49 (0.67) (130) Mathematics scores: mean (SD) (no. of subjects) Arm 1: Baseline: 97.2 (12.6) (144); 14-month follow-up: 99.7 (13.0) (124) Arm 2: Baseline: 97.7 (13.2) (144); 14-month follow-up: 100.3 (13.7) (134) Arm 3: Baseline: 97.9 (15.1) (145); 14-month follow-up: 100.5 (16.4) (136) Arm 4: Baseline: 98.6 (14.1) (146); 14-month follow-up: 100.4 (14.2) (131) Hyperactive/impulsive: teacher rating: mean (SD) (no. of subjects) Arm 1: Baseline: 2.08 (0.71) (135); 14-month follow-up: 0.82 (0.69) (120) Arm 2: Baseline: 2.05 (0.75) (136); 14-month follow-up: 1.10 (0.77) (119) Arm 3: Baseline: 1.89 (0.77) (137); 14-month follow-up: 0.75 (0.71) (134) Arm 4: Baseline: 1.93 (0.81) (135); 14-month follow-up: 1.25 (0.84) (128) Hyperactive/impulsive: parent rating: mean (SD) (no. of subjects) Arm 1: Baseline: 1.89 (0.62) (140); 14-month follow-up: 0.91 (0.65) (121) Arm 2: Baseline: 1.89 (0.64) (140); 14-month follow-up: 1.24 (0.72) (129) Arm 3: Baseline: 1.91 (0.69) (140); 14-month follow-up: 1.85 (0.63) (133) Arm 4: Baseline: 1.95 (0.67) (142); 14-month follow-up: 1.35 (0.72) (130) Spelling scores: mean (SD) (no. of subjects) Arm 1: Baseline: 95.2 (13.1) (144); 14-month follow-up: 96.0 (14.8) (124) Arm 2: Baseline: 92.8 (12.5) (144); 14-month follow-up: 93.7 (13.9) (134) Arm 3: Baseline: 95.1 (14.8) (144); 14-month follow-up: 97.0 (14.4) (136) Arm 4: Baseline: 93.7 (13.1) (146); 14-month follow-up: 94.2 (14.1) (131) Hyperactive/impulsive: classroom observer rating: mean (SD) (no. of subjects) Arm 1: Baseline: 0.31 (0.21) (119); 14-month follow-up: 0.16 (0.15) (110) Arm 2: Baseline: 0.37 (0.26) (120); 14-month follow-up: 0.29 (0.26) (107) Arm 3: Baseline: 0.33 (0.22) (122); 14-month follow-up: 0.21 (0.20) (114) Arm 4: Baseline: 0.38 (0.27) (118); 14-month follow-up: 0.18 (0.15) (109) Conclusions Authors’ conclusions: For ADHD symptoms, medication management was superior to behavioural treatment and to routine community care that included medication. Combined treatment did not yield significantly greater benefits than medication management for core ADHD symptoms, but may have provided modest advantages for non-ADHD symptoms and positive functioning outcomes Reviewer’s comments: No comments noted
Appendix 13 © Queen’s Printer and Controller of HMSO 2006. All rights reserved. Health Technology Assessment 2006; Vol. 10: No. 23 Data extraction table of the systematic review of adverse events 365
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