APPENDICES. A systematic review and economic model of the ...

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Appendix 12
Core symptoms Educational performance Quality of life Adverse events
Physician Rating Sheet: incidence (MPH,
placebo)
Insomnia and sleep problems: 3, 5
Anorexia and appetite problems: 8, 5
Increased crying: 10, 5
Stomach ache: 9, 7
Headache: 5, 2
Increased irritability: 2, 0
Increased nervousness: 1, 1
Nausea: 1, 2
Dizziness: 1, 2
Rash: 0, 3
Moodiness: 2, 0
Temper tantrums: 0, 0
Thirsty: 1, 0
Itching: 2, 0
Depression: 1, 1
Increased appetite: 1, 1
Glassy eyed: 1, 1
Nose bleed: 1, 1
Enuresis: 0, 2
Argumentative: 0, 0
Sensitive to light: 0, 0
Night terrors: 0, 0
Stares glassily: 0, 0
Fine tremors: 0, 0
Dilated pupils: 0, 0
Leg cramps: 0, 0
Odd mannerism of mouth: 0, 0
Bad dreams: 0, 0
Increased sensitivity: 0, 0
Diarrhoea: 0, 0
Palpitations: 1, 0
Stuttering: 1, 0
Negativism: 1, 0
Nocturnal fears: 1, 0
Eyes reddened: 1, 0
Speech incoherent: 1, 0
Eating erratic: 0, 1
Grouchy: 0, 1
Parent global judgements of
improvement (how serious a
problem does your child have?
no/minor/serious problem): At
week 8, % responding ‘serious
problem’:
PEM: 17.6%; MPH: 27.8%; PLA:
50% (2 =6.67, p < 0.155)
Wide Range Achievement: reading:
mean (SEM)
MPH: baseline 2.33 (0.25) (n = 20),
8 weeks 2.66 (0.25) (n = 20)
Placebo: baseline 2.35 (0.26) (n = 20),
8 weeks 2.56 (0.26) (n = 20)
No significant differences
Conners’ Parent Questionnaire: hyperactivity:
mean (SD)
MPH: baseline 0.99 (0.36) (n = 20), 8 weeks
0.46 (0.23) (n = 20)
Placebo: baseline 0.98 (0.36) (n = 21), 8 weeks
0.75 (0.36) (n = 20)
Not significant, p = 0.069
Parent rating of problems
compared with peers (much
worse, worse, same, better, much
better) at baseline no differences
between groups: at 8 weeks %
‘same or better’: PEM: 71%;
MPH: 90%; PLA: 37%
(2 =18.422, p < 0.019)
Wide Range Achievement: spelling:
mean (SEM)
MPH: baseline 2.09 (0.19) (n = 20),
8 weeks 2.37 (0.24) (n = 20)
Placebo: baseline 2.07 (0.20) (n = 20),
8 weeks 2.14 (0.20) (n = 20)
No significant differences.
Conners’ Parent Questionnaire: impulsivity: mean
(SD)
MPH: baseline 1.53 (0.56) (n = 20), 8 weeks
0.69 (0.52) (n = 20)
Placebo: baseline 1.45 (0.51) (n =21), 8 weeks
1.31 (0.57) (n = 20)
MPH > Placebo, p < 0.001
Teacher rating of problems
compared with peers (much
worse, worse, same, better, much
better):
at 8 weeks no significant difference
between groups
Wide Range Achievement: arithmetic:
mean (SD)
MPH: baseline 2.24 (0.17) (n = 20),
8 weeks 2.58 (0.17) (n = 20)
Placebo: baseline 1.93 (0.19) (n = 20),
8 weeks 2.22 (0.22) (n = 20)
No significant differences
Conners’ Teacher Questionnaire:
inattentive–passive: mean (SD)
MPH: baseline 1.86 (0.49) (n = 20), 8 weeks 1.20
(0.73), (n = 19)
Placebo: baseline 1.65 (0.80) (n = 21), 8 weeks
1.25 (0.73) (n = 19)
Not significant, p-value not reported
Conners’ Teacher Questionnaire: hyperactivity:
mean (SD)
MPH: baseline 2.24 (0.55) (n = 20), 8 weeks
1.28 (0.67) (n = 19)
Placebo: baseline 1.90 (0.50) (n = 21), 8 weeks
1.45 (0.63) (n =19)
MPH > Placebo, p = 0.039
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