APPENDICES. A systematic review and economic model of the ...

Core symptoms Educational performance Quality of life Adverse events
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Health Technology Assessment 2006; Vol. 10: No. 23
Not reported Not reported Teacher-rated side-effects: mean (SD) and
number of subjects experiencing adverse sideeffects
for placebo, 0.3 mg/kg, 0.6 mg/kg
Repetitive tongue movements
0.3 (1.0) 1, 0.3 (0.7) 2, 0.4 (1.0) 2
Motor or vocal twitches
0.3 (1.0) 1, 0.3 (0.7) 2, 0.2 (0.6) 1
Nervous movements
0.4 (1.0) 2, 0.6 (1.1) 3, 0.2 (0.4) 2
Tearful, prone to crying
0.8 (1.5) 3, 0.7 (1.6) 3, 0.1 (0.3) 1
Dull, not alert
0.4 (0.7) 3, 1.5 (1.7) 6, 2.2 (2.0) 7
Sad, unhappy, depressed
0.2 (0.4) 2, 0.5 (1.6) 1, 0.6 (1.1) 3
Staring, daydreaming
1.8 (2.1) 6, 2.0 (1.6) 7, 1.7 (2.2) 5
Social withdrawal, talks less
0.4 (1.0) 2, 1.3 (1.9) 6, 2.1 (2.4) 5
Irritable
0.6 (1.0) 4, 0.9 (1.5) 3, 1.2 (1.9) 4
Poor appetite
0.1 (0.3) 1, 1.9 (2.4) 5, 3.2 (2.9) 6
Dizzy, balance unstable
0.0 (0.0) 0, 0.2 (0.7) 2, 0.0 (0.0) 0
Anxiety
0.0 (0.0) 0, 0.1 (0.3) 1, 0.3 (0.5) 3
Headaches
0.0 (0.0) 0, 0.1 (0.3) 1, 0.0 (0.0) 0
Stomach aches, nausea
0.0 (0.0) 0, 0.1 (0.3) 1, 0.0 (0.0) 0
Restless, high activity level
5.0 (1.1) 9, 3.0 (1.6) 6, 1.1 (1.6) 5
Crabby, touchy, whiny
1.0 (1.4) 4, 1.0 (1.7) 3, 0.7 (1.3) 4
Excessive talking
2.8 (2.4) 7, 1.0 (1.2) 5, 0.6 (1.1) 3
Drowsiness
0.0 (0.0) 0, 1.1 (1.8) 3, 0.6 (0.8) 4
CTRS: mean (SD) for placebo,0.3 mg/kg,
0.6 mg/kg
Hyperactivity
14.0 (3.7), 9.0 (5.1), 6.2 (3.4), p =0.001
(post hoc: 0.6 mg/kg > placebo, p < 0.05)
Inattention–Passivity
12.8 (4.3), 9.9 (3.9), 8.9 (3.7), p = 0.03
(post hoc: 0.6 mg/kg > placebo,
p < 0.05)
Hyperactivity Index
17.4 (6.0), 11.9 (5.7), 9.2 (3.8), p = 0.006
(post hoc: 0.6 mg/kg > Placebo,
p < 0.05)
Preschool Behaviour Questionnaire: mean
(SD) for placebo, 0.3 mg/kg, 0.6 mg/kg
Hyperactive–distractible
7.0 (1.5), 4.7 (2.5), 3.8 (1.5), p = 0.001
(post hoc: 0.6 mg/kg > placebo,
p < 0.05)
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