APPENDICES. A systematic review and economic model of the ...

276
Appendix 12
Core symptoms Educational performance Quality of life Adverse events
Not reported Barkley’s SERS (nurse): number of side effects: Mean (SD)
for Adderall/DEX-ER/DEX-IR/placebo
3.3(2.0)/2.9(1.8)/2.6(1.8)/2.0(1.9), F(3,23) = 3.94, p = 0.02
Nurse ratings revealed a significantly increased number of
adverse effects. Adderall had significantly greater number of
adverse effects than placebo (p = 0.04)
Barkley’s SERS (nurse) severity of reported adverse effects:
Mean (SD) for Adderall/DEX-ER/DEX-IR/placebo
2.7(1.5)/3.1(2.0)/2.7(1.7)/1.8(1.2), F = 3.6, p = 0.03
Nurse ratings revealed a greater mean severity of reported
adverse effects, F (3,23) = 3.56, p = 0.03. DEX-ER had
significantly greater severity of reported adverse effects
compared with placebo (p = 0.02)
Total attempted maths problems:
mean (SD) for Adderall/DEX-
ER/DEXs-IR/placebo
171.6 (56.4)/187.0 (60.9)/177.4
(42.9)/147.7 (50.7), F = 6.3,
p = 0.002. Stimulants significantly
increased the number of maths
problems attempted. DEX-IT and
DEX-ER both significantly increased
the number of problems attempted
relative to placebo (p = 0.01 and
0.003, respectively)
CTRS: hyperactivity (9 a.m. to 12.30 p.m.):
mean (SD) for Adderall/DEX-ER/DEX-
IR/placebo: 50.6 (5.6)/53.7 (9.1)/50.5
(5.4)/63.1(12.6), F = 15.7, p < 0.001
DEX-IR, which did not differ significantly from
Adderall, decreased teacher-rated
hyperactivity significantly more than DEX-ER
(p = 0.025).
Higher doses were significantly more effective
than lower doses for all three medications
[F(1,34) = 5.38, p = 0.03]
Barkley’s SERS (parent) Number of side effects: Mean (SD)
for Adderall/DEX-ER/DEX-IR/placebo
6.3(2.7)/6.7(2.9)/6.4(3.5)/5.9(3.2), F = 0.3, p = NS
Barkley’s SERS (parent) severity of reported side effects:
Mean (SD) for Adderall/DEX-ER/DEX-IR/placebo
3.2(1.2)/3.7(1.5)/3.2(1.6)/2.8(1.5), F = 2.2, p = NS
Total correct maths problems: mean
(SD) for Adderall/DEX-ER/DEX-
IR/placebo
164.6(55.9)/177.6(61.1)/167.6(41.2)/1
40.2 (51.3) F = 5.6, p = 0.003. DEX-
IR and DEX-ER significantly increased
the number of problems done
correctly compared with placebo
(p = 0.02 and 0.003, respectively)
Conners’ Psychiatric Rating Scale:
hyperactivity between (1 and 3 p.m.):
Mean (SD) for Adderall/DEX-ER/DEX-
IR/placebo: 2.8 (1.0)/2.3 (1.0)/2.5 (1.1)/3.8
(1.1), F = 35, p < 0.001
Across doses, all three active drugs were
significantly more effective than placebo
(p < 0.001)
A higher dose was significantly more effective
than a lower dose [F(1,31) = 8.65, p = 0.006]
DEX-ER decreased hyperactive behaviour
significantly more than Adderall (p = 0.04)
Mean magnitude of adverse effects rated by parents and
staff nurse for Adderall/DEX-ER/DEX-IR/placebo
Trouble sleeping, nightmares, daydreams, talks less with
others, uninterested in others, irritable, stomach aches,
headaches, drowsiness, sadness/happiness, prone to crying,
anxiousness, bites fingernails, euphoric, dizziness, tics,
p = NS
Poor appetite, p =