APPENDICES. A systematic review and economic model of the ...

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Appendix 12
Core symptoms Educational performance Quality of life Adverse events
Not reported
CGI (teacher/mothers/psychiatrists).
Improvement rates [n (%)] after
8 weeks of treatment
Arm 1: 20 (69%)/22 (76%)/23 (79%),
n =29
Arm 2: 27 (93%)/27 (93%)/28 (97%),
n =29
Arm 3: 18 (57%)/18 (64%)/14 (50%),
n =28
Wide Range Achievement Test:
Reading: mean (SD) scores before/after
treatment
Arm 1: 3.40 (1.6)/3.9 (1.9)
Arm 2: 3.1 (1.9)/3.7 (2.0)
Arm 3: 3.4 (1.6)/3.73 (1.8)
No significant differences
CTRS: overall severity. Adjusted mean (SD) factor scores
before/after treatment (12 weeks)
Arm 1: 2.7 (0.5)/1.2 (1.0), n = 29
Arm 2: 2.7 (0.6)/0.9 (0.8), n = 29
Arm 3: 2.9 (0.4)/2.1 (0.9), n = 28
MPH > BT (t = 3.57, p = 0.003); comb > BT (t = 5.32,
p = 0.001); MPH vs comb (not significant)
Wide Range Achievement Test:
Arithmetic: mean (SD) scores
before/after treatment
Arm 1: 3.0 (1.2)/3.3 (1.1)
Arm 2: 2.7 (1.3)/3.2 (1.4)
Arm 3: 2.8 (0.9)/3.12 (1.0)
No significant differences
CTRS: inattention. Adjusted mean (SD) factor scores before/after
treatment (12 weeks)
Arm 1: 1.7 (0.6)/0.9 (0.5), n = 29
Arm 2: 1.7 (0.5)/0.7 (0.5), n = 29
Arm 3: 1.7 (0.6)/1.2 (0.6), n = 28
Comb > BT (t = 3.77, p = 0.001); other comparisons not
significant
Wide Range Achievement Test:
Spelling: mean (SD) scores before/after
treatment
Arm 1: 3.0 (1.6)/3.3 (1.6)
Arm 2: 2.7 (2.0)/3.1 (1.8)
Arm 3: 2.8 (1.3)/3.05 (1.2)
No significant differences
CTRS: hyperactivity. Adjusted mean (SD) factor scores before/after
treatment (12 weeks)
Arm 1: 2.5 (0.4)/1.1 (0.4), n = 29
Arm 2: 2.3 (0.3)/0.8 (0.4), n = 29
Arm 3: 2.3 (0.4)/1.5 (0.6), n = 28
MPH > BT (t = 3.02, p = 0.01); comb > BT (t = 5.28, p = 0.001);
MPH vs comb (not significant)
CPRS: impulsivity. Adjusted mean (SD) factor scores before/after
treatment (12 weeks)
Arm 1: 1.1 (0.6)/0.7 (0.8), n = 28
Arm 2: 1.0 (0.4)/0.5 (0.5), n = 28
Arm 3: 1.4 (0.7)/0.8 (0.7), n = 27
No significant differences
CPRS: hyperactivity. Adjusted mean (SD) factor scores before/after
treatment (12 weeks)
Arm 1: 1.2 (0.2)/0.7 (0.5), n = 28
Arm 2: 1.1 (0.1)/0.6 (0.3), n = 28
Arm 3: 1.1 (0.2)/0.8 (0.4), n = 27
No significant differences
Hillside Behaviour Scale: concentration (teachers). Adjusted mean
(SD) factor scores before/after treatment (12 week)
Arm 1: 3.3 (0.8)/2.2 (0.8), n = 25
Arm 2: 3.2 (0.7)/1.8 (0.6), n = 23
Arm 3: 3.1 (0.7)/2.6 (0.8), n = 25
Comb > BT (t = 3.89, p = 0.001); other comparisons not significant
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