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The Australian Immunisation Handbook 10th Edition 2013

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Immunoglobulin or blood product administration after vaccination<br />

Immunoglobulin-containing products should not be administered for 3 weeks<br />

following vaccination with measles-containing vaccines, unless the benefits<br />

exceed those of vaccination. If immunoglobulin-containing products are<br />

administered within this interval, the vaccinated person should either be<br />

revaccinated later at the appropriate time following the product (as indicated in<br />

Table 3.3.6), or be tested for immunity 6 months later and then revaccinated if<br />

seronegative.<br />

Rh (D) immunoglobulin (anti-D) may be given at the same time in different sites<br />

with separate syringes or at any time in relation to MMR vaccine, as it does not<br />

interfere with the antibody response to the vaccine.<br />

HIV-infected persons<br />

MMR vaccine can be given to asymptomatic HIV-infected persons >12 months<br />

of age with an age-specific CD4 + count of ≥15% 49 (see 3.3 Groups with special<br />

vaccination requirements, Table 3.3.4 Categories of immunocompromise in HIV-infected<br />

persons, based on age-specific CD4 + counts and percentage of total lymphocytes). This is<br />

because the risk posed by measles infection is considered to be greater than the<br />

likelihood of adverse events from vaccination. 46 MMR vaccine is contraindicated<br />

in immunocompromised HIV-infected persons (see 4.9.9 Contraindications above).<br />

As there are no data available on the safety, immunogenicity or efficacy of MMRV<br />

vaccines in HIV-infected children, MMRV vaccine should not be administered as<br />

a substitute for MMR vaccine when vaccinating these children. 25,48<br />

Persons receiving immunosuppressive therapy<br />

MMR-containing vaccines may be given to persons on low-dose systemic<br />

corticosteroid therapy (e.g. children on doses of ≤2 mg/kg per day for less than<br />

1 week, and those on lower doses of 1 mg/kg per day or alternate-day regimens<br />

for longer periods). Persons receiving high-dose corticosteroids can receive<br />

MMR-containing vaccines after corticosteroid therapy has been discontinued<br />

for at least 1 month (see 4.9.9 Contraindications above). 46 Some experts<br />

suggest withholding lower doses of steroids 2 to 3 weeks prior to vaccination<br />

with live viral vaccines, if this is possible. 46,48 (See also 3.3.3 Vaccination of<br />

immunocompromised persons.)<br />

Household contacts of persons who are immunocompromised<br />

Household contacts of persons who are immunocompromised, should ensure<br />

that they are age-appropriately vaccinated against, or are immune to, measles,<br />

as well as mumps, rubella and varicella. MMR-containing vaccines can be safely<br />

administered to household contacts, as measles, mumps and rubella vaccine<br />

viruses are not transmissible from vaccinated persons to others. 25 If using MMRV<br />

vaccine, see 4.22 Varicella for information regarding varicella vaccine virus<br />

transmission.<br />

PART 4 VACCINE-PREVENTABLE DISEASES 277<br />

4.9 MEASLES

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