Autism Studies and Related Medical Conditions, January 2009 - TACA

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associated with autistic disorder fulfilling the diagnostic criteria of the American Psychiatric Association Manual of Psychiatric Diseases, 4th edition, and briefly reviews the literature on autistic disorder associated with mitochondrial disorders. Autism Studies & Related Medical Conditions – TACA © Page 10
2- Autism and Gastrointestinal Inflammation (101 citations) Afzal, M. A. and P. D. Minor (2002). "Vaccines, Crohn's disease and autism." Mol Psychiatry 7 Suppl 2: S49-50. Afzal, M. A., P. D. Minor, et al. (2001). "Measles virus persistence in specimens of inflammatory bowel disease and autism cases." Dig Dis Sci 46(3): 658-60. Afzal, N., S. Murch, et al. (2003). "Constipation with acquired megarectum in children with autism." Pediatrics 112(4): 939-42. OBJECTIVE: Recent evidence suggests that autistic children may have significant gastrointestinal symptoms. Although constipation occurs in 2% to 5% of healthy children, its clinical diagnosis is often difficult in children with behavioral disorders. We thus aimed to assess the prevalence of fecal loading in autistic children with gastrointestinal symptoms and to identify possible predictors of constipation. METHODS: We studied abdominal radiographs of 103 autistic children (87 boys) who were referred for gastroenterological assessment, in comparison with 29 control radiographs from children who were referred to the emergency department, most with abdominal pain. Radiographs were scored independently, in blinded manner, by 4 pediatric gastroenterologists and a radiologist. The severity of constipation was determined using a validated index. Details of stool habit, abdominal pain, dietary history, and laxative use were obtained from case notes. RESULTS: The incidence of constipation in the control subjects with abdominal pain was higher than reported for normal children. Despite this, moderate or severe constipation was more frequent in the autistic group than in the control subjects (36% vs 10%). Analysis of rectosigmoid loading showed more striking differences (54.4% of autistic children had moderate/severe loading or acquired megarectum compared with 24.1% of control subjects). Multivariate regression analysis showed consumption of milk to be the strongest predictor of constipation in the autistic group, whereas stool frequency, gluten consumption, soiling, and abdominal pain were not predictive of constipation. CONCLUSIONS: Constipation is a frequent finding in children with gastrointestinal symptoms and autism, particularly in the rectosigmoid colon, often with acquired megarectum. The absence of any correlation between the clinical history and the degree of fecal impaction in autistic children confirms the importance of an abdominal radiograph in the assessment of their degree of constipation. Ashwood, P., A. Anthony, et al. (2003). "Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology." J Clin Immunol 23(6): 504-17. Inflammatory intestinal pathology has been reported in children with regressive autism (affected children). Detailed analysis of intestinal biopsies in these children indicates a novel lymphocytic enterocolitis with autoimmune features; Autism Studies & Related Medical Conditions – TACA © Page 11
Page 1 and 2: Autism Studies & Related Medical Co
Page 3 and 4: Values of free and total carnitine
Page 5 and 6: observation suggests that certain m
Page 7 and 8: with autism. These data suggest tha
Page 9: Markers rs2056202 and rs2292813 wer
Page 13 and 14: than in nondisease controls (p
Page 15 and 16: Buie, T. M. (2005). "Gastroesophage
Page 17 and 18: control children and significant nu
Page 19 and 20: Horvath, K. and J. A. Perman (2002)
Page 21 and 22: components indicates a role of NFH
Page 23 and 24: patients with Crohn disease, one of
Page 25 and 26: analyzed by a registered pediatric
Page 27 and 28: oligonucleotide probes targeting pr
Page 29 and 30: would be effective in alleviating c
Page 31 and 32: demonstrate a focal CD8-dominated g
Page 33 and 34: Chlamydia pneumoniae and Streptococ
Page 35 and 36: vaccine (MCV), and once-exposed chi
Page 37 and 38: Wakefield, A. J., S. H. Murch, et a
Page 39 and 40: Walker SJ, Hepner K, Segal J, Krigs
Page 41 and 42: R, Maisawa S, Miki K. Guidelines fo
Page 43 and 44: approximately 73 and 37kDa in plasm
Page 45 and 46: Cook, E. H., Jr., B. D. Perry, et a
Page 47 and 48: evealed, that AAb level may serve a
Page 49 and 50: findings, which consisted of obstru
Page 51 and 52: angiography was performed in all fo
Page 53 and 54: matched non-autistic siblings had d
Page 55 and 56: Todd, R. D. and R. D. Ciaranello (1
Page 57 and 58: eaction was further confirmed by DO
Page 59 and 60: asic protein (MBP) and glial acidic
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exhibit higher than average levels
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Feasby, T., B. Banwell, et al. (200
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each group participated. Observatio
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Rossignol, D. A., L. W. Rossignol,
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Tsuru, T., M. Mori, et al. (2000).
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Anderson, M. P., B. S. Hooker, et a
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continue. The documented prevalence
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contributing factors may contribute
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Chauhan, V., A. Chauhan, et al. (20
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and folate-dependent methionine syn
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confirmed would indicate that autis
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differed significantly in the patie
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end products (AGE's) in autism brai
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cells in area 22 (p
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nutritional, and toxic status in au
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increase in autism in the last deca
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morphological, genetic and animal m
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Rossignol, D. A. (2007). "Hyperbari
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conditions have demonstrated improv
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not been investigated yet, several
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positively correlated in the autist
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abnormalities are present in brain,
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(tetrahydrobiopterin) were selected
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7 - Autism & Infection - 22 citatio
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micro-organisms. The faecal flora o
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Research Support, U.S. Gov't, P.H.S
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presentation of this syndrome among
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disorder. Yamashita Y, Fujimoto C,
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chronic infection may predispose to
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Streptococcus group A. Vojdani A, C
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provides a detailed analysis of a n
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PMID: 16897390 [PubMed - indexed fo
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syndrome and substance abuse, and a
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to contribute to metal-induced neur
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School of Medical Sciences, Tottori
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Review PMID: 16198633 [PubMed - ind
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diseases in humans. Zinc is redox-i
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Office of Vaccines Research and Rev
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into ferritin or heme. It is not ye
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9 - Dietary Intervention Studies -
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different peptidases resulting in a
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Mechanisms of non-IgE mediated adve
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Reichelt KL, Knivsberg AM.: Can the
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observations is the opioid-excess t
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Patients with gluten ataxia have an
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Hadjivassiliou M, Grunewald RA, Law
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Carroccio A, Montalto G, Custro N,
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Alberti A, Pirrone P, Elia M, Warin
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Thus, a number of milk protein frag
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Abstract: Institute ofPediatrics, L
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Abstract: Service de Psychopatholog
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times peer week) was effective in i
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Reichelt K.L., Knivsberg A.M., Lind
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terminal tetrapeptides into the lef
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Considerable clinical evidence sugg
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material of the P2 fractionation st
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Huebner FR, Lieberman KW, Rubino RP
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Four aspects of clinical evidence f
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Dohan FC: Wheat "consumption" and h
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from 24 children with autism from o
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matched control group. There was a
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administration on certain disorders
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Coleman M, Steinberg G, Tippett J,
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Dolske MC, Spollen J, McKay S, Lanc
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and myo-inositol (-13%) concentrati
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cobalamin. This was associated with
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(significantly lower ratio of SAM t
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Fifty-three controlled trials of th
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PMID: 6765503 [PubMed - indexed for
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Liebscher DH, Liebscher DE. About t
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from patients were examined at outs
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National College of Naturopathic Me
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OBJECTIVE: Ionic magnesium (Mg(2+))
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Pfeiffer CC, Braverman ER. Zinc, th
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evidence support a role for omega-3
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scavenge reactive species, then the
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hyperactivity in patients with ADHD
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esponse to folate deprivation. Expr
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improvement may only become apparen
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Walsh WJ, Glab LB, Haakenson ML. Re
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use other internal or external stan
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In contrast, therapy with very high
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increased in affected children comp
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largely unknown, but genetic, envir
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Campbell DB, Sutcliffe JS, Ebert PJ
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OBJECTIVE: Etiologically unexplaine
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globulin and gamma globulins, IgA,
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Fallon J. Could one of the most wid
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Th1-like (IL-2, IFN-gamma) and Th2-
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Jyonouchi H, Geng L, Ruby A, Reddy
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that may be partly associated with
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Department of Neurology, University
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Mehler MF, Kessler JA. Cytokines in
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Niehus R, Lord C. Early medical his
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Pletnikov MV, Jones ML, Rubin SA, M
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Silva SC, Correia C, Fesel C, Barre
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cytokines were measured using speci
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sera) and cerebellum (9% positive s
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Department of Psychiatry, Indiana U
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(DSM)-IV and the International Clas
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Vojdani A, Campbell AW, Anyanwu E,
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Warren RP, Cole P, Odell JD, Pingre
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mechanisms in children with autism.
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12 - Environmental Toxicities (4 ci
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13 - Thimerosal and Toxicity A comp
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Eye Contact Lens. 2007 Jul;33(4):19
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[Contact allergy to preservatives c
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Marn-Pernat A, Buturović-Ponikvar
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[Thiomersal and immunisations] Weis
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50: The evidence for the safety of
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59: Thimerosal induces DNA breaks,
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68: [Effect of the preservative thi
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Mutat Res. 1993 May;287(1):29-46. P
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Krug HF, Culig H. Mol Pharmacol. 19
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Effect of organic and inorganic mer
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Determination of mercury and organo
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Cytotoxicity of mercurial preservat
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Bourdineaud JP, Bellance N, Bénard
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14: Binstock Citations Controversie
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neurodevelopmental delays, which in
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14. Geier DA, Geier MR. A comparati
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29. Boyd Haley, Ph.D. Reduced Level
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40c. Iacono G et al. Intolerance of
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affected children compared with bot
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"OBJECTIVE: Intestinal pathology, i
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67. Jeff Bradstreet, M.D. A Case-co
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in autistic children. In this curre
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87. Semba RD. Vitamin A and immunit
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"These results suggest that large o
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94. Bluhm DP, Summers RS. Plasma vi
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neonatal gut is different from that
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108. Thony B et al. Tetrahydrobiopt
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"Six chemicals, 2-halopropionic aci
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immunological functions in diseases
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[Note etiologic connection with thi
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149. Magazzu G, Scoglio R. Gastroin
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clinical presentations make celiac
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169a. Hadjivassiliou M et al. Does
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174. Headache and CNS white matter
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histology is difficult to interpret
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(n=25): marked 4%, moderate 28%, sl
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199. Stubbs EG et al. Autism and co
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205. Gill HS, Guarner F. Probiotics
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patients with IBS. Since the fermen
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demonstrate that probiotics possess
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237. James Neubrander, M.D. -- Bioc
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significantly more frequent in pati
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aseline. Physicians reported qualit
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http://www.publichealthreports.org/
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No Trade Name Sanofi Pasteur, Ltd 0
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Influenza, live FluMist MedImmune V
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Calculating Aluminum in Vaccines He
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16 - How Much Money is Spent on Vac
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consumer information (promotion mat
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evidence to the mercury-vaccine-aut
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More from Verstraeten (Now working
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18 -Difference between Number of Va
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