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Autism Studies and Related Medical Conditions, January 2009 - TACA

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Pletnikov MV, Jones ML, Rubin SA, Moran TH, Carbone KM. Rat model of autism<br />

spectrum disorders. Genetic background effects on Borna disease virus-induced<br />

developmental brain damage. Ann N Y Acad Sci. 2001 Jun;939:318-9.<br />

Department of Psychiatry, Johns Hopkins University School of Medicine,<br />

Baltimore, Maryl<strong>and</strong>, USA.<br />

PMID: 11462786 [PubMed - indexed for MEDLINE]<br />

Plioplys AV. <strong>Autism</strong>: electroencephalogram abnormalities <strong>and</strong> clinical improvement with<br />

valproic acid. Arch Pediatr Adolesc Med. 1994 Feb;148(2):220-2.<br />

Plioplys AV.<br />

Division of Neurology, Mercy Hospital <strong>and</strong> <strong>Medical</strong> Center, Chicago, IL 60616.<br />

PMID: 8118547 [PubMed - indexed for MEDLINE]<br />

Plioplys AV, Greaves A. Yoshida W. Anti-CNS antibodies in childhood neurologic<br />

diseases. Neuropediatrics. 1989;20:93.<br />

Department of Pediatrics, Hospital for Sick Children, University of Toronto,<br />

Ontario, Canada.<br />

To study the incidence of circulating anti-CNS antibodies in childhood neurologic<br />

diseases, a population study was undertaken. Serum samples were obtained<br />

from a total of 348 children <strong>and</strong> stored at -80 degrees C until being studied. The<br />

samples were collected when routine blood tests were being performed. In all<br />

cases informed consent was obtained. This study was approved by hospital<br />

ethics review committees. One hundred <strong>and</strong> ninety-nine of the samples were<br />

from children with no known neurologic illnesses <strong>and</strong> served as the control<br />

group. One hundred <strong>and</strong> twenty-one of the samples were from children with<br />

epilepsy <strong>and</strong> the remaining 28 from a number of different neurologic conditions.<br />

The serum samples were screened against normal, adult, autopsy-derived<br />

cerebellar <strong>and</strong> frontal cortex tissue sections <strong>and</strong> Western blots. Serum<br />

immunoreactivity was revealed using HRP-conjugated anti-human IgG.<br />

Significant findings included: (1) patients with epilepsy had an increased<br />

incidence of anti-CNS reactivity as revealed on frontal cortex immunoblots (p less<br />

<strong>Autism</strong> <strong>Studies</strong> & <strong>Related</strong> <strong>Medical</strong> <strong>Conditions</strong> – <strong>TACA</strong> © Page 255

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