Autism Studies and Related Medical Conditions, January 2009 - TACA

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tissue. Mean cerebellar 3-NT was elevated in autism by 68.9% and the increase was statistically significant (p=0.045). Cerebellar Hg, measured by atomic absorption spectrometry ranged from 0.9 to 35 pmol g¯1 tissue in controls (n=10) and from 3.2 to 80.7 pmol g¯1 tissue in autistic cases (n=9); the 68.2% increase in cerebellar Hg was not statistically significant. However, there was a positive correlation between cerebellar 3-NT and Hg levels (r=0.7961, p=0.0001). A small decrease in cerebellar Se levels in autism, measured by atomic absorption spectroscopy, was not statistically significant but was accompanied by a 42.9% reduction in the molar ratio of Se to Hg in the autistic cerebellum. While preliminary, the results of the present study add elevated oxidative stress markers in brain to the growing body of data reflecting greater oxidative stress in autism. Sierra, C., M. A. Vilaseca, et al. (2001). "Oxidative stress in Rett syndrome." Brain Dev 23 Suppl 1: S236-9. The investigation of parameters that might influence the neurological evolution of Rett syndrome might also yield new information about its pathogenic mechanisms. Oxidative stress caused by oxygen free radicals is involved in the neuropathology of several neurodegenerative disorders, as well as in stroke and seizures. To evaluate the free radical metabolism in Rett syndrome, we measured red blood cell antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase) and plasma malondialdehyde, as lipid peroxidation marker in a group of patients with Rett syndrome. No significant differences were observed in erythrocyte glutathione peroxidase, glutathione reductase and catalase activities, between the Rett syndrome patients and the control group. Erythrocyte superoxide dismutase activities were significantly decreased in Rett syndrome patients (P
not been investigated yet, several recent studies proposed that nitric oxide (NO) and other parameters related to oxidative stress may have a pathophysiological role in autism. METHODS: We assessed the changes in superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and thiobarbituric acid-reactive substances (TBARS) levels in plasma as well as NO levels in red blood cells (RBC) in patients with autism (n=27) compared to age- and sex-matched normal controls (n=30). RESULTS: In the autistic group, increased RBC NO levels (p
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Autism Studies & Related Medical Co
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Values of free and total carnitine
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observation suggests that certain m
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with autism. These data suggest tha
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Markers rs2056202 and rs2292813 wer
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2- Autism and Gastrointestinal Infl
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than in nondisease controls (p
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Buie, T. M. (2005). "Gastroesophage
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control children and significant nu
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Horvath, K. and J. A. Perman (2002)
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components indicates a role of NFH
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patients with Crohn disease, one of
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analyzed by a registered pediatric
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oligonucleotide probes targeting pr
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would be effective in alleviating c
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demonstrate a focal CD8-dominated g
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Chlamydia pneumoniae and Streptococ
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vaccine (MCV), and once-exposed chi
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Wakefield, A. J., S. H. Murch, et a
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Walker SJ, Hepner K, Segal J, Krigs
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R, Maisawa S, Miki K. Guidelines fo
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approximately 73 and 37kDa in plasm
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Cook, E. H., Jr., B. D. Perry, et a
Page 47 and 48: evealed, that AAb level may serve a
Page 49 and 50: findings, which consisted of obstru
Page 51 and 52: angiography was performed in all fo
Page 53 and 54: matched non-autistic siblings had d
Page 55 and 56: Todd, R. D. and R. D. Ciaranello (1
Page 57 and 58: eaction was further confirmed by DO
Page 59 and 60: asic protein (MBP) and glial acidic
Page 61 and 62: exhibit higher than average levels
Page 63 and 64: Feasby, T., B. Banwell, et al. (200
Page 65 and 66: each group participated. Observatio
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Page 73 and 74: continue. The documented prevalence
Page 75 and 76: contributing factors may contribute
Page 77 and 78: Chauhan, V., A. Chauhan, et al. (20
Page 79 and 80: and folate-dependent methionine syn
Page 81 and 82: confirmed would indicate that autis
Page 83 and 84: differed significantly in the patie
Page 85 and 86: end products (AGE's) in autism brai
Page 87 and 88: cells in area 22 (p
Page 89 and 90: nutritional, and toxic status in au
Page 91 and 92: increase in autism in the last deca
Page 93 and 94: morphological, genetic and animal m
Page 95 and 96: Rossignol, D. A. (2007). "Hyperbari
Page 97: conditions have demonstrated improv
Page 101 and 102: positively correlated in the autist
Page 103 and 104: abnormalities are present in brain,
Page 105 and 106: (tetrahydrobiopterin) were selected
Page 107 and 108: 7 - Autism & Infection - 22 citatio
Page 109 and 110: micro-organisms. The faecal flora o
Page 111 and 112: Research Support, U.S. Gov't, P.H.S
Page 113 and 114: presentation of this syndrome among
Page 115 and 116: disorder. Yamashita Y, Fujimoto C,
Page 117 and 118: chronic infection may predispose to
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observations is the opioid-excess t
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Patients with gluten ataxia have an
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Hadjivassiliou M, Grunewald RA, Law
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Carroccio A, Montalto G, Custro N,
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Alberti A, Pirrone P, Elia M, Warin
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Thus, a number of milk protein frag
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Abstract: Institute ofPediatrics, L
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Abstract: Service de Psychopatholog
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times peer week) was effective in i
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Reichelt K.L., Knivsberg A.M., Lind
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terminal tetrapeptides into the lef
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Considerable clinical evidence sugg
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material of the P2 fractionation st
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Huebner FR, Lieberman KW, Rubino RP
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Four aspects of clinical evidence f
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Dohan FC: Wheat "consumption" and h
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from 24 children with autism from o
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matched control group. There was a
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administration on certain disorders
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Coleman M, Steinberg G, Tippett J,
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Dolske MC, Spollen J, McKay S, Lanc
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and myo-inositol (-13%) concentrati
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cobalamin. This was associated with
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(significantly lower ratio of SAM t
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Fifty-three controlled trials of th
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PMID: 6765503 [PubMed - indexed for
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Liebscher DH, Liebscher DE. About t
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from patients were examined at outs
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National College of Naturopathic Me
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OBJECTIVE: Ionic magnesium (Mg(2+))
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Pfeiffer CC, Braverman ER. Zinc, th
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evidence support a role for omega-3
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scavenge reactive species, then the
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hyperactivity in patients with ADHD
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esponse to folate deprivation. Expr
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improvement may only become apparen
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Walsh WJ, Glab LB, Haakenson ML. Re
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use other internal or external stan
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In contrast, therapy with very high
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increased in affected children comp
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largely unknown, but genetic, envir
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Campbell DB, Sutcliffe JS, Ebert PJ
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OBJECTIVE: Etiologically unexplaine
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globulin and gamma globulins, IgA,
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Fallon J. Could one of the most wid
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Th1-like (IL-2, IFN-gamma) and Th2-
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that may be partly associated with
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cytokines were measured using speci
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sera) and cerebellum (9% positive s
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Department of Psychiatry, Indiana U
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(DSM)-IV and the International Clas
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Vojdani A, Campbell AW, Anyanwu E,
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Warren RP, Cole P, Odell JD, Pingre
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mechanisms in children with autism.
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12 - Environmental Toxicities (4 ci
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13 - Thimerosal and Toxicity A comp
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[Contact allergy to preservatives c
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affected children compared with bot
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in autistic children. In this curre
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clinical presentations make celiac
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histology is difficult to interpret
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significantly more frequent in pati
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aseline. Physicians reported qualit
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No Trade Name Sanofi Pasteur, Ltd 0
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Influenza, live FluMist MedImmune V
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Calculating Aluminum in Vaccines He
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16 - How Much Money is Spent on Vac
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consumer information (promotion mat
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evidence to the mercury-vaccine-aut
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More from Verstraeten (Now working
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18 -Difference between Number of Va
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