Autism Studies and Related Medical Conditions, January 2009 - TACA

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eceptors and glutamate transporters in the cerebellum. These abnormalities may be directly involved in the pathogenesis of the disorder. Silva, S. C., C. Correia, et al. (2004). "Autoantibody repertoires to brain tissue in autism nuclear families." J Neuroimmunol 152(1-2): 176-82. The hypothesis of an immune dysfunction in autism spectrum disorders has previously been put forward without, however, compelling evidence of a direct relation to its etiology or pathogenesis. To further understand if autoimmunity could play a significant role in autism, we analyzed autoantibody repertoires to brain tissue extract in the plasma of 171 autism children, their parents, and 54 controls, by quantitative immunoblotting. Multiparametric analysis revealed significant differences between patients and controls, and showed that one single reactivity in Section 32 of the blot had the most power to discriminate between these samples. Family correlation coefficients and heritability estimates did not provide any evidence that this reactivity was genetically determined. While the molecular weight of the target protein suggested that it might be an isoform of Myelin Basic Protein (MBP), inhibition assays with human MBP argued against this hypothesis. The study evidences the widespread occurrence of autoreactivities to brain tissue in autism patients, which may represent the immune system's neuroprotective response to a previous brain injury occurred during neurodevelopment. The molecular identification of the target protein in Section 32 will contribute to the understanding of the role of immune responses against brain antigens in autistic patients. Singer, H. S., C. M. Morris, et al. (2007). "Antibodies against fetal brain in sera of mothers with autistic children." J Neuroimmunol. Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates human and rodent fetal and adult brain tissues, GFAP, and MBP. MCAD had significantly more individuals with Western immunoblot bands at 36 kDa in human fetal and rodent embryonic brain tissue. The density of bands was greater in fetal brain at 61 kDa. MCAD plus developmental regression had greater reactivity against human fetal brain at 36 and 39 kDa. Data support a possible complex association between genetic/metabolic/environmental factors and the placental transfer of maternal antibodies in autism. Singer, H. S., C. M. Morris, et al. (2006). "Antibrain antibodies in children with autism and their unaffected siblings." J Neuroimmunol 178(1-2): 149-55. Serum autoantibodies to human brain, identified by ELISA and Western immunoblotting, were evaluated in 29 children with autism spectrum disorder (22 with autistic disorder), 9 non-autistic siblings and 13 controls. More autistic subjects than controls had bands at 100 kDa in caudate, putamen and prefrontal cortex (p
matched non-autistic siblings had denser bands (peak height and/or area under the curve) at 73 kDa in the cerebellum and cingulate gyrus than did controls (p
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Page 3 and 4: Values of free and total carnitine
Page 5 and 6: observation suggests that certain m
Page 7 and 8: with autism. These data suggest tha
Page 9 and 10: Markers rs2056202 and rs2292813 wer
Page 11 and 12: 2- Autism and Gastrointestinal Infl
Page 13 and 14: than in nondisease controls (p
Page 15 and 16: Buie, T. M. (2005). "Gastroesophage
Page 17 and 18: control children and significant nu
Page 19 and 20: Horvath, K. and J. A. Perman (2002)
Page 21 and 22: components indicates a role of NFH
Page 23 and 24: patients with Crohn disease, one of
Page 25 and 26: analyzed by a registered pediatric
Page 27 and 28: oligonucleotide probes targeting pr
Page 29 and 30: would be effective in alleviating c
Page 31 and 32: demonstrate a focal CD8-dominated g
Page 33 and 34: Chlamydia pneumoniae and Streptococ
Page 35 and 36: vaccine (MCV), and once-exposed chi
Page 37 and 38: Wakefield, A. J., S. H. Murch, et a
Page 39 and 40: Walker SJ, Hepner K, Segal J, Krigs
Page 41 and 42: R, Maisawa S, Miki K. Guidelines fo
Page 43 and 44: approximately 73 and 37kDa in plasm
Page 45 and 46: Cook, E. H., Jr., B. D. Perry, et a
Page 47 and 48: evealed, that AAb level may serve a
Page 49 and 50: findings, which consisted of obstru
Page 51: angiography was performed in all fo
Page 55 and 56: Todd, R. D. and R. D. Ciaranello (1
Page 57 and 58: eaction was further confirmed by DO
Page 59 and 60: asic protein (MBP) and glial acidic
Page 61 and 62: exhibit higher than average levels
Page 63 and 64: Feasby, T., B. Banwell, et al. (200
Page 65 and 66: each group participated. Observatio
Page 67 and 68: Rossignol, D. A., L. W. Rossignol,
Page 69 and 70: Tsuru, T., M. Mori, et al. (2000).
Page 71 and 72: Anderson, M. P., B. S. Hooker, et a
Page 73 and 74: continue. The documented prevalence
Page 75 and 76: contributing factors may contribute
Page 77 and 78: Chauhan, V., A. Chauhan, et al. (20
Page 79 and 80: and folate-dependent methionine syn
Page 81 and 82: confirmed would indicate that autis
Page 83 and 84: differed significantly in the patie
Page 85 and 86: end products (AGE's) in autism brai
Page 87 and 88: cells in area 22 (p
Page 89 and 90: nutritional, and toxic status in au
Page 91 and 92: increase in autism in the last deca
Page 93 and 94: morphological, genetic and animal m
Page 95 and 96: Rossignol, D. A. (2007). "Hyperbari
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Page 101 and 102: positively correlated in the autist
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abnormalities are present in brain,
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(tetrahydrobiopterin) were selected
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7 - Autism & Infection - 22 citatio
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micro-organisms. The faecal flora o
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Research Support, U.S. Gov't, P.H.S
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presentation of this syndrome among
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disorder. Yamashita Y, Fujimoto C,
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chronic infection may predispose to
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Streptococcus group A. Vojdani A, C
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provides a detailed analysis of a n
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PMID: 16897390 [PubMed - indexed fo
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syndrome and substance abuse, and a
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to contribute to metal-induced neur
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School of Medical Sciences, Tottori
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Review PMID: 16198633 [PubMed - ind
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diseases in humans. Zinc is redox-i
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Office of Vaccines Research and Rev
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into ferritin or heme. It is not ye
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9 - Dietary Intervention Studies -
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different peptidases resulting in a
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Mechanisms of non-IgE mediated adve
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Reichelt KL, Knivsberg AM.: Can the
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observations is the opioid-excess t
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Patients with gluten ataxia have an
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Hadjivassiliou M, Grunewald RA, Law
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Carroccio A, Montalto G, Custro N,
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Alberti A, Pirrone P, Elia M, Warin
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Thus, a number of milk protein frag
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Abstract: Institute ofPediatrics, L
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Abstract: Service de Psychopatholog
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times peer week) was effective in i
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Reichelt K.L., Knivsberg A.M., Lind
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terminal tetrapeptides into the lef
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Considerable clinical evidence sugg
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material of the P2 fractionation st
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Huebner FR, Lieberman KW, Rubino RP
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Four aspects of clinical evidence f
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Dohan FC: Wheat "consumption" and h
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from 24 children with autism from o
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matched control group. There was a
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administration on certain disorders
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Coleman M, Steinberg G, Tippett J,
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Dolske MC, Spollen J, McKay S, Lanc
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and myo-inositol (-13%) concentrati
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cobalamin. This was associated with
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(significantly lower ratio of SAM t
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Fifty-three controlled trials of th
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PMID: 6765503 [PubMed - indexed for
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Liebscher DH, Liebscher DE. About t
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from patients were examined at outs
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National College of Naturopathic Me
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OBJECTIVE: Ionic magnesium (Mg(2+))
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Pfeiffer CC, Braverman ER. Zinc, th
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evidence support a role for omega-3
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scavenge reactive species, then the
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hyperactivity in patients with ADHD
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esponse to folate deprivation. Expr
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improvement may only become apparen
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Walsh WJ, Glab LB, Haakenson ML. Re
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use other internal or external stan
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In contrast, therapy with very high
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increased in affected children comp
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largely unknown, but genetic, envir
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Campbell DB, Sutcliffe JS, Ebert PJ
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OBJECTIVE: Etiologically unexplaine
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globulin and gamma globulins, IgA,
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Fallon J. Could one of the most wid
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Th1-like (IL-2, IFN-gamma) and Th2-
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Jyonouchi H, Geng L, Ruby A, Reddy
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that may be partly associated with
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Department of Neurology, University
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Mehler MF, Kessler JA. Cytokines in
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Niehus R, Lord C. Early medical his
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Pletnikov MV, Jones ML, Rubin SA, M
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Silva SC, Correia C, Fesel C, Barre
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cytokines were measured using speci
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sera) and cerebellum (9% positive s
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Department of Psychiatry, Indiana U
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(DSM)-IV and the International Clas
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Vojdani A, Campbell AW, Anyanwu E,
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Warren RP, Cole P, Odell JD, Pingre
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mechanisms in children with autism.
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12 - Environmental Toxicities (4 ci
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13 - Thimerosal and Toxicity A comp
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Eye Contact Lens. 2007 Jul;33(4):19
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[Contact allergy to preservatives c
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Marn-Pernat A, Buturović-Ponikvar
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[Thiomersal and immunisations] Weis
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50: The evidence for the safety of
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59: Thimerosal induces DNA breaks,
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68: [Effect of the preservative thi
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Mutat Res. 1993 May;287(1):29-46. P
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Krug HF, Culig H. Mol Pharmacol. 19
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Effect of organic and inorganic mer
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Determination of mercury and organo
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Cytotoxicity of mercurial preservat
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Bourdineaud JP, Bellance N, Bénard
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14: Binstock Citations Controversie
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neurodevelopmental delays, which in
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14. Geier DA, Geier MR. A comparati
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29. Boyd Haley, Ph.D. Reduced Level
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40c. Iacono G et al. Intolerance of
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affected children compared with bot
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"OBJECTIVE: Intestinal pathology, i
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67. Jeff Bradstreet, M.D. A Case-co
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in autistic children. In this curre
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87. Semba RD. Vitamin A and immunit
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"These results suggest that large o
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94. Bluhm DP, Summers RS. Plasma vi
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neonatal gut is different from that
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108. Thony B et al. Tetrahydrobiopt
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"Six chemicals, 2-halopropionic aci
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immunological functions in diseases
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[Note etiologic connection with thi
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149. Magazzu G, Scoglio R. Gastroin
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clinical presentations make celiac
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169a. Hadjivassiliou M et al. Does
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174. Headache and CNS white matter
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histology is difficult to interpret
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(n=25): marked 4%, moderate 28%, sl
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199. Stubbs EG et al. Autism and co
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205. Gill HS, Guarner F. Probiotics
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patients with IBS. Since the fermen
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demonstrate that probiotics possess
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237. James Neubrander, M.D. -- Bioc
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significantly more frequent in pati
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aseline. Physicians reported qualit
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http://www.publichealthreports.org/
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No Trade Name Sanofi Pasteur, Ltd 0
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Influenza, live FluMist MedImmune V
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Calculating Aluminum in Vaccines He
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16 - How Much Money is Spent on Vac
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consumer information (promotion mat
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evidence to the mercury-vaccine-aut
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More from Verstraeten (Now working
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18 -Difference between Number of Va
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