Autism Studies and Related Medical Conditions, January 2009 - TACA

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families that have probands with pervasive developmental disorders (PDDs), including autism, compared with 2 control groups. METHODS: Three well-defined study groups, including 1) families that have a child with a PDD, 2) families that have a child with an autoimmune disorder, and 3) families with a healthy control child, constituted the sample. A questionnaire inquiring about which first- and second-degree family members had received a diagnosis of having specific autoimmune disorders was completed by 101 families in each group. RESULTS: The frequency of autoimmune disorders was significantly higher in families of the PDD probands compared with families of both the autoimmune and healthy control probands. Autoimmunity was highest among the parents of PDD probands compared with parents of the healthy control subjects. Hypothyroidism/Hashimoto's thyroiditis and rheumatic fever were significantly more common in families with PDD probands than in the healthy control families. CONCLUSIONS: Autoimmunity was increased significantly in families with PDD compared with those of healthy and autoimmune control subjects. These preliminary findings warrant additional investigation into immune and autoimmune mechanisms in autism. PMID: 14595086 [PubMed - indexed for MEDLINE] Sweeten TL, Posey DJ, McDougle CJ. Brief report: autistic disorder in three children with cytomegalovirus infection. J Autism Dev Disord. 2004 Oct;34(5):583-6. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4800, USA. Previous research has identified a relationship between autistic disorder (autism) and specific congenital infections. Three cases of congenital or perinatal cytomegalovirus (CMV) infection occurring in association with autism are described. Hypothetical mechanisms relating congenital infection, such as CMV, to the development of autism are discussed. A better understanding of the immunologic response to certain congenital infections may provide important information pertaining to the pathophysiology and etiology of autism in vulnerable individuals. PMID: 15628611 [PubMed - indexed for MEDLINE] Sweeten TL, Posey DJ, Shankar S, McDougle CJ. High nitric oxide production in autistic disorder: a possible role for interferon-gamma. Bio Psychiatry. 2004 Feb 15:55(4):434- 7. Autism Studies & Related Medical Conditions – TACA © Page 262
Department of Psychiatry, Indiana University School of Medicine, 1111 W. 10th Street, Indianapolis, IN 46202-4800, USA. BACKGROUND: Neuroimmune regulation abnormalities have been implicated in the pathophysiology of autistic disorder. Nitric oxide (NO) is involved in immune reactivity and is known to affect brain neurodevelopmental processes. Recent evidence indicates that NO, and cytokines involved in NO production, may be high in children with autism. The purpose of this study was to verify that plasma NO is high in children with autism and determine whether this elevation is related to plasma levels of cytokines involved in NO production. METHODS: The metabolites of NO, nitrite, and nitrate (NOx), along with the cytokines interferongamma (IFN-gamma), tumor necrosis factor-alpha, and interleukin-1beta, were measured in plasma of 29 children with autism (mean age +/- SD = 6.1 +/- 2.8 years) and 27 age- and gender-matched healthy comparison subjects using commercially available assay kits. RESULTS: Plasma levels of NOx were significantly higher in the autistic subjects (p =.006); plasma levels of the cytokines did not differ between groups. NOx and IFN-gamma levels were positively correlated in the autistic subjects (r =.51; p =.005). CONCLUSIONS: These results confirm that plasma NO is high in some children with autism and suggest that this elevation may be related to IFN-gamma activity. PMID: 14960298 [PubMed - indexed for MEDLINE] Swisher CN, Swisher L. Letter: Congenital rubella and autistic behavior. N Engl J Med. 1975 Jul 24;293(4):198. Swisher CN, Swisher L. PMID: 1134536 [PubMed - indexed for MEDLINE] Todd RD, Hickok JM, Anderson GM, Cohen DJ. Antibrain antibodies in infantile autism. Biol Psychiatry. 1988 Mar 15;23(6):644-7. Todd RD, Hickok JM, Anderson GM, Cohen DJ. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110. PMID: 3355880 [PubMed - indexed for MEDLINE] Autism Studies & Related Medical Conditions – TACA © Page 263
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Autism Studies & Related Medical Co
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Values of free and total carnitine
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observation suggests that certain m
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with autism. These data suggest tha
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Markers rs2056202 and rs2292813 wer
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2- Autism and Gastrointestinal Infl
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than in nondisease controls (p
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Buie, T. M. (2005). "Gastroesophage
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control children and significant nu
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Horvath, K. and J. A. Perman (2002)
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components indicates a role of NFH
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patients with Crohn disease, one of
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analyzed by a registered pediatric
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oligonucleotide probes targeting pr
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would be effective in alleviating c
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demonstrate a focal CD8-dominated g
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Chlamydia pneumoniae and Streptococ
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vaccine (MCV), and once-exposed chi
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Wakefield, A. J., S. H. Murch, et a
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Walker SJ, Hepner K, Segal J, Krigs
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R, Maisawa S, Miki K. Guidelines fo
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approximately 73 and 37kDa in plasm
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Cook, E. H., Jr., B. D. Perry, et a
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evealed, that AAb level may serve a
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findings, which consisted of obstru
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angiography was performed in all fo
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matched non-autistic siblings had d
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Todd, R. D. and R. D. Ciaranello (1
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eaction was further confirmed by DO
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asic protein (MBP) and glial acidic
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exhibit higher than average levels
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Feasby, T., B. Banwell, et al. (200
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each group participated. Observatio
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Rossignol, D. A., L. W. Rossignol,
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Tsuru, T., M. Mori, et al. (2000).
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Anderson, M. P., B. S. Hooker, et a
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continue. The documented prevalence
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contributing factors may contribute
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Chauhan, V., A. Chauhan, et al. (20
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and folate-dependent methionine syn
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confirmed would indicate that autis
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differed significantly in the patie
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end products (AGE's) in autism brai
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cells in area 22 (p
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nutritional, and toxic status in au
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increase in autism in the last deca
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morphological, genetic and animal m
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Rossignol, D. A. (2007). "Hyperbari
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conditions have demonstrated improv
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not been investigated yet, several
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positively correlated in the autist
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abnormalities are present in brain,
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(tetrahydrobiopterin) were selected
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7 - Autism & Infection - 22 citatio
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micro-organisms. The faecal flora o
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Research Support, U.S. Gov't, P.H.S
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presentation of this syndrome among
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disorder. Yamashita Y, Fujimoto C,
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chronic infection may predispose to
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Streptococcus group A. Vojdani A, C
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provides a detailed analysis of a n
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PMID: 16897390 [PubMed - indexed fo
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syndrome and substance abuse, and a
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to contribute to metal-induced neur
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School of Medical Sciences, Tottori
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Review PMID: 16198633 [PubMed - ind
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diseases in humans. Zinc is redox-i
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Office of Vaccines Research and Rev
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into ferritin or heme. It is not ye
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9 - Dietary Intervention Studies -
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different peptidases resulting in a
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Mechanisms of non-IgE mediated adve
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Reichelt KL, Knivsberg AM.: Can the
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observations is the opioid-excess t
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Patients with gluten ataxia have an
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Hadjivassiliou M, Grunewald RA, Law
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Carroccio A, Montalto G, Custro N,
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Alberti A, Pirrone P, Elia M, Warin
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Thus, a number of milk protein frag
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Abstract: Institute ofPediatrics, L
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Abstract: Service de Psychopatholog
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times peer week) was effective in i
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Reichelt K.L., Knivsberg A.M., Lind
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terminal tetrapeptides into the lef
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Considerable clinical evidence sugg
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material of the P2 fractionation st
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Huebner FR, Lieberman KW, Rubino RP
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Four aspects of clinical evidence f
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Dohan FC: Wheat "consumption" and h
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from 24 children with autism from o
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matched control group. There was a
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administration on certain disorders
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Coleman M, Steinberg G, Tippett J,
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Dolske MC, Spollen J, McKay S, Lanc
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and myo-inositol (-13%) concentrati
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cobalamin. This was associated with
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(significantly lower ratio of SAM t
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Fifty-three controlled trials of th
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PMID: 6765503 [PubMed - indexed for
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Liebscher DH, Liebscher DE. About t
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from patients were examined at outs
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National College of Naturopathic Me
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OBJECTIVE: Ionic magnesium (Mg(2+))
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Page 217 and 218: scavenge reactive species, then the
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Page 237 and 238: OBJECTIVE: Etiologically unexplaine
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No Trade Name Sanofi Pasteur, Ltd 0
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Influenza, live FluMist MedImmune V
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Calculating Aluminum in Vaccines He
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16 - How Much Money is Spent on Vac
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consumer information (promotion mat
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evidence to the mercury-vaccine-aut
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