Autism Studies and Related Medical Conditions, January 2009 - TACA

PMID: 1307234 [PubMed - indexed for MEDLINE]
Schectman G, Byrd JC, Hoffmann R. Ascorbic acid requirements for smokers: analysis of
a population survey. Am J Clin Nutr. 1991 Jun;53(6):1466-70.
Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee
53226.
The recommended dietary allowance (RDA) of ascorbic acid for smokers was
recently increased from 60 to 100 mg. To determine whether this new RDA for
smokers is sufficient to reduce the risk of low serum ascorbic acid (AA)
concentrations (LoC) to the same concentration as nonsmokers, we analyzed the
dietary intakes and serum concentrations of AA in 11,582 adult respondents in
the National Health and Nutrition Examination Survey (1976-1980). Serum AA
concentrations and the risk of LoC (serum ascorbic acid levels less than 23
mumol/L) for smokers consuming different amounts of AA were compared with
those for nonsmokers whose AA intake exceeded the RDA (60 mg). Serum AA
concentrations were reduced, and risk of LoC increased, in smokers maintaining
AA intakes greater than 60, 100, and 150 mg. Only smokers consuming greater
than 200 mg AA/d had serum ascorbate concentrations and risk of LoC
equivalent to nonsmokers meeting the RDA.
PMID: 2035475 [PubMed - indexed for MEDLINE
Schoon EJ, Muller MC, Vermeer C, Schurgers LJ, Brummer RJ, Stockbrugger RW. Low
serum and bone vitamin K status in patients with longstanding Crohn's disease: another
pathogenetic factor of osteoporosis in Crohn's disease? Gut. 2001 Apr;48(4):473-7.
Department of Gastroenterology and Hepatology, University Hospital Maastricht,
Maastricht, the Netherlands. ESCH@sint.azm.nl
BACKGROUND: A high prevalence of osteoporosis is reported in Crohn's disease.
The pathogenesis is not completely understood but is probably multifactorial.
Longstanding Crohn's disease is associated with a deficiency of fat soluble
vitamins, among them vitamin K. Vitamin K is a cofactor in the carboxylation of
osteocalcin, a protein essential for calcium binding to bone. A high level of
circulating uncarboxylated osteocalcin is a sensitive marker of vitamin K
deficiency. AIMS: To determine serum and bone vitamin K status in patients with
Crohn's disease and to elucidate its relationship with bone mineral density.
METHODS: Bone mineral density was measured in 32 patients with longstanding
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