Autism Studies and Related Medical Conditions, January 2009 - TACA

provides a detailed analysis of a new animal model of ASD. This model utilizes
neonatal Borna disease virus (BDV) infection of the rat brain as a unique
experimental teratogen to study the pathogenesis of neurodevelopmental damage.
For more than a decade, studies of the BDV animal model have yielded much insight
into the pathogenic processes of abnormal brain development and resulting
autistic-like behavioral abnormalities in rats. The most recent experiments
demonstrate the utility of the BDV model for studying the pathophysiological
mechanisms of the gene-environment interaction that determines differential
disease outcomes and variability in responses to treatments.
Publication Types:
Research Support, U.S. Gov't, P.H.S.
Review
PMID: 11861216 [PubMed - indexed for MEDLINE]
23: Ann N Y Acad Sci. 2001 Jun;939:318-9.
Rat model of autism spectrum disorders. Genetic background effects on Borna
disease virus-induced developmental brain damage.
Pletnikov MV, Jones ML, Rubin SA, Moran TH, Carbone KM.
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore,
Maryland, USA.
PMID: 11462786 [PubMed - indexed for MEDLINE]
24: Curr Top Microbiol Immunol. 2001;253:157-77.
Borna disease virus infection of adult and neonatal rats: models for
neuropsychiatric disease.
Hornig M, Solbrig M, Horscroft N, Weissenböck H, Lipkin WI.
Laboratory for the Study of Emerging Diseases, 3101 Gillespie Neuroscience
Research Facility, University of California, Irvine, CA 92697-4292, USA.
Animal models provide unique opportunities to explore interactions between host
and environment. Two models have been established based on Borna disease virus
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