Autism Studies and Related Medical Conditions, January 2009 - TACA

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with other neurologic disorders. Aspartate aminotransferase was elevated in 38% of patients with autism compared with 15% of controls (P
Rossignol, D. A. (2007). "Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism." Med Hypotheses 68(6): 1208-27. Autism is a neurodevelopmental disorder currently affecting as many as 1 out of 166 children in the United States. Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion, neuroinflammation and gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, neurotransmitter abnormalities, impaired detoxification of toxins, dysbiosis, and impaired production of porphyrins. Many of these findings have been correlated with core autistic symptoms. For example, cerebral hypoperfusion in autistic children has been correlated with repetitive, self-stimulatory and stereotypical behaviors, and impairments in communication, sensory perception, and social interaction. Hyperbaric oxygen therapy (HBOT) might be able to improve each of these problems in autistic individuals. Specifically, HBOT has been used with clinical success in several cerebral hypoperfusion conditions and can compensate for decreased blood flow by increasing the oxygen content of plasma and body tissues. HBOT has been reported to possess strong anti-inflammatory properties and has been shown to improve immune function. There is evidence that oxidative stress can be reduced with HBOT through the upregulation of antioxidant enzymes. HBOT can also increase the function and production of mitochondria and improve neurotransmitter abnormalities. In addition, HBOT upregulates enzymes that can help with detoxification problems specifically found in autistic children. Dysbiosis is common in autistic children and HBOT can improve this. Impaired production of porphyrins in autistic children might affect the production of heme, and HBOT might help overcome the effects of this problem. Finally, HBOT has been shown to mobilize stem cells from the bone marrow to the systemic circulation. Recent studies in humans have shown that stem cells can enter the brain and form new neurons, astrocytes, and microglia. It is expected that amelioration of these underlying pathophysiological problems through the use of HBOT will lead to improvements in autistic symptoms. Several studies on the use of HBOT in autistic children are currently underway and early results are promising. Rossignol, D. A. and J. J. Bradstreet (2008). "Evidence of mitochondrial dysfunction in autism and implications for treatment." American Journal of Biochemistry and Biotechnology 4(2): 208-217. Classical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms. It is not associated with discernable mitochondrial pathology in muscle biopsy specimens despite objective evidence of lowered mitochondrial functioning. Exposure to environ-mental toxins is the likely etiology for MtD in autism. This dysfunction then contributes to a number of diagnostic Autism Studies & Related Medical Conditions – TACA © Page 95
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Autism Studies & Related Medical Co
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Values of free and total carnitine
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observation suggests that certain m
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with autism. These data suggest tha
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Markers rs2056202 and rs2292813 wer
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2- Autism and Gastrointestinal Infl
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than in nondisease controls (p
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Buie, T. M. (2005). "Gastroesophage
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control children and significant nu
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Horvath, K. and J. A. Perman (2002)
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components indicates a role of NFH
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patients with Crohn disease, one of
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analyzed by a registered pediatric
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oligonucleotide probes targeting pr
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would be effective in alleviating c
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demonstrate a focal CD8-dominated g
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Chlamydia pneumoniae and Streptococ
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vaccine (MCV), and once-exposed chi
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Wakefield, A. J., S. H. Murch, et a
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Walker SJ, Hepner K, Segal J, Krigs
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R, Maisawa S, Miki K. Guidelines fo
Page 43 and 44: approximately 73 and 37kDa in plasm
Page 45 and 46: Cook, E. H., Jr., B. D. Perry, et a
Page 47 and 48: evealed, that AAb level may serve a
Page 49 and 50: findings, which consisted of obstru
Page 51 and 52: angiography was performed in all fo
Page 53 and 54: matched non-autistic siblings had d
Page 55 and 56: Todd, R. D. and R. D. Ciaranello (1
Page 57 and 58: eaction was further confirmed by DO
Page 59 and 60: asic protein (MBP) and glial acidic
Page 61 and 62: exhibit higher than average levels
Page 63 and 64: Feasby, T., B. Banwell, et al. (200
Page 65 and 66: each group participated. Observatio
Page 67 and 68: Rossignol, D. A., L. W. Rossignol,
Page 69 and 70: Tsuru, T., M. Mori, et al. (2000).
Page 71 and 72: Anderson, M. P., B. S. Hooker, et a
Page 73 and 74: continue. The documented prevalence
Page 75 and 76: contributing factors may contribute
Page 77 and 78: Chauhan, V., A. Chauhan, et al. (20
Page 79 and 80: and folate-dependent methionine syn
Page 81 and 82: confirmed would indicate that autis
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Page 87 and 88: cells in area 22 (p
Page 89 and 90: nutritional, and toxic status in au
Page 91 and 92: increase in autism in the last deca
Page 93: morphological, genetic and animal m
Page 97 and 98: conditions have demonstrated improv
Page 99 and 100: not been investigated yet, several
Page 101 and 102: positively correlated in the autist
Page 103 and 104: abnormalities are present in brain,
Page 105 and 106: (tetrahydrobiopterin) were selected
Page 107 and 108: 7 - Autism & Infection - 22 citatio
Page 109 and 110: micro-organisms. The faecal flora o
Page 111 and 112: Research Support, U.S. Gov't, P.H.S
Page 113 and 114: presentation of this syndrome among
Page 115 and 116: disorder. Yamashita Y, Fujimoto C,
Page 117 and 118: chronic infection may predispose to
Page 119 and 120: Streptococcus group A. Vojdani A, C
Page 121 and 122: provides a detailed analysis of a n
Page 123 and 124: PMID: 16897390 [PubMed - indexed fo
Page 125 and 126: syndrome and substance abuse, and a
Page 127 and 128: to contribute to metal-induced neur
Page 129 and 130: School of Medical Sciences, Tottori
Page 131 and 132: Review PMID: 16198633 [PubMed - ind
Page 133 and 134: diseases in humans. Zinc is redox-i
Page 135 and 136: Office of Vaccines Research and Rev
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Page 139 and 140: into ferritin or heme. It is not ye
Page 141 and 142: 9 - Dietary Intervention Studies -
Page 143 and 144: different peptidases resulting in a
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Mechanisms of non-IgE mediated adve
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Reichelt KL, Knivsberg AM.: Can the
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observations is the opioid-excess t
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Patients with gluten ataxia have an
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Hadjivassiliou M, Grunewald RA, Law
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Carroccio A, Montalto G, Custro N,
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Alberti A, Pirrone P, Elia M, Warin
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Thus, a number of milk protein frag
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Abstract: Institute ofPediatrics, L
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Abstract: Service de Psychopatholog
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times peer week) was effective in i
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Reichelt K.L., Knivsberg A.M., Lind
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terminal tetrapeptides into the lef
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Considerable clinical evidence sugg
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material of the P2 fractionation st
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Huebner FR, Lieberman KW, Rubino RP
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Four aspects of clinical evidence f
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Dohan FC: Wheat "consumption" and h
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from 24 children with autism from o
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matched control group. There was a
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administration on certain disorders
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PMID: 16581239 [PubMed - indexed fo
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Coleman M, Steinberg G, Tippett J,
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Dolske MC, Spollen J, McKay S, Lanc
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and myo-inositol (-13%) concentrati
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cobalamin. This was associated with
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(significantly lower ratio of SAM t
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Fifty-three controlled trials of th
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PMID: 6765503 [PubMed - indexed for
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Liebscher DH, Liebscher DE. About t
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from patients were examined at outs
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National College of Naturopathic Me
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OBJECTIVE: Ionic magnesium (Mg(2+))
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Pfeiffer CC, Braverman ER. Zinc, th
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evidence support a role for omega-3
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scavenge reactive species, then the
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hyperactivity in patients with ADHD
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esponse to folate deprivation. Expr
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improvement may only become apparen
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Walsh WJ, Glab LB, Haakenson ML. Re
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use other internal or external stan
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In contrast, therapy with very high
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increased in affected children comp
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largely unknown, but genetic, envir
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Campbell DB, Sutcliffe JS, Ebert PJ
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OBJECTIVE: Etiologically unexplaine
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globulin and gamma globulins, IgA,
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Fallon J. Could one of the most wid
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Th1-like (IL-2, IFN-gamma) and Th2-
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Jyonouchi H, Geng L, Ruby A, Reddy
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that may be partly associated with
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Department of Neurology, University
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Mehler MF, Kessler JA. Cytokines in
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cytokines were measured using speci
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sera) and cerebellum (9% positive s
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Department of Psychiatry, Indiana U
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(DSM)-IV and the International Clas
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Vojdani A, Campbell AW, Anyanwu E,
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Warren RP, Cole P, Odell JD, Pingre
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mechanisms in children with autism.
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12 - Environmental Toxicities (4 ci
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13 - Thimerosal and Toxicity A comp
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[Contact allergy to preservatives c
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affected children compared with bot
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in autistic children. In this curre
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clinical presentations make celiac
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histology is difficult to interpret
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(n=25): marked 4%, moderate 28%, sl
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No Trade Name Sanofi Pasteur, Ltd 0
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Influenza, live FluMist MedImmune V
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Calculating Aluminum in Vaccines He
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16 - How Much Money is Spent on Vac
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consumer information (promotion mat
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evidence to the mercury-vaccine-aut
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More from Verstraeten (Now working
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18 -Difference between Number of Va
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