Autism Studies and Related Medical Conditions, January 2009 - TACA

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Torrente F, Ashwood P, Day R, Machado N, Furlano RI, Anthony A, Davies SE, Wakefield AJ, Thomson MA, Walker-Smith JA, Murch SH. Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. Mol Psychiatry. 2002;7(4):375-82, 334. Centre for Paediatric Gastroenterology, Royal Free & University College Medical School, London, UK. We have reported lymphocytic colitis in children with regressive autism, with epithelial damage prominent. We now compare duodenal biopsies in 25 children with regressive autism to 11 with coeliac disease, five with cerebral palsy and mental retardation and 18 histologically normal controls. Immunohistochemistry was performed for lymphocyte and epithelial lineage and functional markers. We determined the density of intraepithelial and lamina propria lymphocyte populations, and studied mucosal immunoglobulin and complement C1q localisation. Standard histopathology showed increased enterocyte and Paneth cell numbers in the autistic children. Immunohistochemistry demonstrated increased lymphocyte infiltration in both epithelium and lamina propria with upregulated crypt cell proliferation, compared to normal and cerebral palsy controls. Intraepithelial lymphocytes and lamina propria plasma cells were lower than in coeliac disease, but lamina propria T cell populations were higher and crypt proliferation similar. Most strikingly, IgG deposition was seen on the basolateral epithelial surface in 23/25 autistic children, co-localising with complement C1q. This was not seen in the other conditions. These findings demonstrate a novel form of enteropathy in autistic children, in which increases in mucosal lymphocyte density and crypt cell proliferation occur with epithelial IgG deposition. The features are suggestive of an autoimmune lesion. PMID: 11986981 [PubMed - indexed for MEDLINE] Trajkovski V, Ajdinski L, Spiroski M. Plasma concentration of immunoglobulin classes and subclasses in children with autism in the Republic of Macedonia: retrospective study. Croat Med J. 2004 Dec;45(6):746-9. Institute of Immunobiology and Human Genetics, Medical Faculty, PO Box 60, 1109 Skopje, Republic of Macedonia. AIM: To examine plasma concentration of IgA, IgM, IgG classes, and IgG1, IgG2, IgG3, and IgG4 subclasses in children with autism. METHODS: Infantile autism was diagnosed by the Diagnostic and Statistical Manual for Mental Disorders Autism Studies & Related Medical Conditions – TACA © Page 264
(DSM)-IV and the International Classification of Diseases (ICD)-10 criteria. Plasma samples were collected from 35 autistic subjects, and their 21 siblings (biological brothers and sisters) who served as healthy controls. Plasma samples were separated by centrifugation and stored at -20 degrees C until the determination. Plasma immunoglobulin classes (IgM, IgA, IgG) and subclasses (IgG1, IgG2, IgG3, IgG4) were determined using a nephelometer. RESULTS: Plasma concentrations (mean+/-standard deviation) of IgM and IgG in autistic children (1.36+/-0.31 g/L and 13.14+/-1.27 g/L, respectively) were significantly higher (p=0.031 and p=0.023, respectively) in comparison with their healthy brothers or sisters (1.20+/-0.15 g/L and 12.39+/-0.96 g/L, respectively). Children with autism had significantly higher plasma concentrations of IgG4 (p
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Autism Studies & Related Medical Co
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Values of free and total carnitine
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observation suggests that certain m
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with autism. These data suggest tha
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Markers rs2056202 and rs2292813 wer
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2- Autism and Gastrointestinal Infl
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than in nondisease controls (p
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Buie, T. M. (2005). "Gastroesophage
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control children and significant nu
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Horvath, K. and J. A. Perman (2002)
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components indicates a role of NFH
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patients with Crohn disease, one of
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analyzed by a registered pediatric
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oligonucleotide probes targeting pr
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would be effective in alleviating c
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demonstrate a focal CD8-dominated g
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Chlamydia pneumoniae and Streptococ
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vaccine (MCV), and once-exposed chi
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Wakefield, A. J., S. H. Murch, et a
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Walker SJ, Hepner K, Segal J, Krigs
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R, Maisawa S, Miki K. Guidelines fo
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approximately 73 and 37kDa in plasm
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Cook, E. H., Jr., B. D. Perry, et a
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evealed, that AAb level may serve a
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findings, which consisted of obstru
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angiography was performed in all fo
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matched non-autistic siblings had d
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Todd, R. D. and R. D. Ciaranello (1
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eaction was further confirmed by DO
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asic protein (MBP) and glial acidic
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exhibit higher than average levels
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Feasby, T., B. Banwell, et al. (200
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each group participated. Observatio
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Rossignol, D. A., L. W. Rossignol,
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Tsuru, T., M. Mori, et al. (2000).
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Anderson, M. P., B. S. Hooker, et a
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continue. The documented prevalence
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contributing factors may contribute
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Chauhan, V., A. Chauhan, et al. (20
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and folate-dependent methionine syn
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confirmed would indicate that autis
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differed significantly in the patie
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end products (AGE's) in autism brai
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cells in area 22 (p
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nutritional, and toxic status in au
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increase in autism in the last deca
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morphological, genetic and animal m
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Rossignol, D. A. (2007). "Hyperbari
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conditions have demonstrated improv
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not been investigated yet, several
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positively correlated in the autist
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abnormalities are present in brain,
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(tetrahydrobiopterin) were selected
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7 - Autism & Infection - 22 citatio
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micro-organisms. The faecal flora o
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Research Support, U.S. Gov't, P.H.S
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presentation of this syndrome among
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disorder. Yamashita Y, Fujimoto C,
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chronic infection may predispose to
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Streptococcus group A. Vojdani A, C
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provides a detailed analysis of a n
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PMID: 16897390 [PubMed - indexed fo
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syndrome and substance abuse, and a
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to contribute to metal-induced neur
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School of Medical Sciences, Tottori
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Review PMID: 16198633 [PubMed - ind
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diseases in humans. Zinc is redox-i
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Office of Vaccines Research and Rev
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into ferritin or heme. It is not ye
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9 - Dietary Intervention Studies -
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different peptidases resulting in a
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Mechanisms of non-IgE mediated adve
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Reichelt KL, Knivsberg AM.: Can the
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observations is the opioid-excess t
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Patients with gluten ataxia have an
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Hadjivassiliou M, Grunewald RA, Law
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Carroccio A, Montalto G, Custro N,
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Alberti A, Pirrone P, Elia M, Warin
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Thus, a number of milk protein frag
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Abstract: Institute ofPediatrics, L
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Abstract: Service de Psychopatholog
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times peer week) was effective in i
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Reichelt K.L., Knivsberg A.M., Lind
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terminal tetrapeptides into the lef
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Considerable clinical evidence sugg
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material of the P2 fractionation st
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Huebner FR, Lieberman KW, Rubino RP
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Four aspects of clinical evidence f
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Dohan FC: Wheat "consumption" and h
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from 24 children with autism from o
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matched control group. There was a
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administration on certain disorders
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Coleman M, Steinberg G, Tippett J,
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Dolske MC, Spollen J, McKay S, Lanc
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and myo-inositol (-13%) concentrati
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cobalamin. This was associated with
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(significantly lower ratio of SAM t
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Fifty-three controlled trials of th
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PMID: 6765503 [PubMed - indexed for
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Liebscher DH, Liebscher DE. About t
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from patients were examined at outs
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National College of Naturopathic Me
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OBJECTIVE: Ionic magnesium (Mg(2+))
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Pfeiffer CC, Braverman ER. Zinc, th
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Page 215 and 216: PMID: 1307234 [PubMed - indexed for
Page 217 and 218: scavenge reactive species, then the
Page 219 and 220: hyperactivity in patients with ADHD
Page 221 and 222: esponse to folate deprivation. Expr
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Page 227 and 228: use other internal or external stan
Page 229 and 230: In contrast, therapy with very high
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Page 237 and 238: OBJECTIVE: Etiologically unexplaine
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Page 245 and 246: Jyonouchi H, Geng L, Ruby A, Reddy
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Page 249 and 250: Department of Neurology, University
Page 251 and 252: Mehler MF, Kessler JA. Cytokines in
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Page 259 and 260: cytokines were measured using speci
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Page 267 and 268: Vojdani A, Campbell AW, Anyanwu E,
Page 269 and 270: Warren RP, Cole P, Odell JD, Pingre
Page 271 and 272: mechanisms in children with autism.
Page 273 and 274: 12 - Environmental Toxicities (4 ci
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Page 307 and 308: 14: Binstock Citations Controversie
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40c. Iacono G et al. Intolerance of
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affected children compared with bot
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"OBJECTIVE: Intestinal pathology, i
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67. Jeff Bradstreet, M.D. A Case-co
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in autistic children. In this curre
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87. Semba RD. Vitamin A and immunit
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"These results suggest that large o
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94. Bluhm DP, Summers RS. Plasma vi
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neonatal gut is different from that
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108. Thony B et al. Tetrahydrobiopt
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"Six chemicals, 2-halopropionic aci
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immunological functions in diseases
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[Note etiologic connection with thi
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149. Magazzu G, Scoglio R. Gastroin
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clinical presentations make celiac
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169a. Hadjivassiliou M et al. Does
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174. Headache and CNS white matter
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histology is difficult to interpret
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(n=25): marked 4%, moderate 28%, sl
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199. Stubbs EG et al. Autism and co
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205. Gill HS, Guarner F. Probiotics
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patients with IBS. Since the fermen
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demonstrate that probiotics possess
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237. James Neubrander, M.D. -- Bioc
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significantly more frequent in pati
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aseline. Physicians reported qualit
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http://www.publichealthreports.org/
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No Trade Name Sanofi Pasteur, Ltd 0
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Influenza, live FluMist MedImmune V
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Calculating Aluminum in Vaccines He
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16 - How Much Money is Spent on Vac
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consumer information (promotion mat
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evidence to the mercury-vaccine-aut
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More from Verstraeten (Now working
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18 -Difference between Number of Va
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