Autism Studies and Related Medical Conditions, January 2009 - TACA

PMID: 16091511 [PubMed - indexed for MEDLINE]
Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with
attention deficit hyperactivity disorder (ADHD). Magnes Res. 1997 Jun;10(2):143-8.
Department of Family Medicine, Pomeranian Medical Academy, Szczecin, Poland.
A positive influence of magnesium in the prevention and treatment of
hyperactivity in children is more and more frequently raised in the literature. The
aim of our work was to estimate magnesium contents in children with attention
deficit hyperactivity disorder, (ADHD). The investigations comprised 116 children
(94 boys and 20 girls), aged 9-12 years, with recognized ADHD. In 68 out of 116
patients examined ADHD occurred with other coexisting disorders specific to the
developmental age and in the remaining 48 patients it occurred together with
disruptive behaviour. Magnesium levels have been determined in blood serum,
red blood cells and in hair with the aid of atomic absorption spectroscopy.
Magnesium deficiency was found in 95 per cent of those examined, most
frequently in hair (77.6 per cent), in red blood cells (58.6 per cent) and in blood
serum (33.6 per cent) of children with ADHD. The conclusion from the
investigations is that magnesium deficiency in children with ADHD occurs more
frequently than in healthy children. Analysis of the material indicated the
correlation between levels of magnesium and the quotient of development to
freedom from distractibility.
PMID: 9368235 [PubMed - indexed for MEDLINE]
Kushak R, Winter W, Farber N, Buie T. Gastrointestinal symptoms and intestinal
disaccharidase activities in children with autism. J Pediatr Gastroenterol Nutr. 2005 Oct:
41(4):508.
Lelord G, Muh JP, Barthelemy C, Martineau J, Garreau B, Callaway E. Effects of
pyridoxine and magnesium on autistic symptoms—initial observations. J Autism Dev
Disord. 1981 Jun;11(2):219-30.
In an open trial, a heterogeneous group of 44 children with autistic symptoms
were treated with large doses of vitamin B6 and magnesium. Clinical
improvement with worsening on termination of the trial was observed in 15
children. Thirteen responders and 8 nonresponders were retested in a 2-week,
crossover, double-blind trial, and the responses to the open trial were confirmed.
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