Autism Studies and Related Medical Conditions, January 2009 - TACA

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159. Management of chronic otitis media with effusion: the role of glutathione.
Laryngoscope. 2001 Aug;111(8):1486-9. PMID: 11568588
"BACKGROUND: The inflammatory cells documented in chronic otitis media with
effusion (OME) spontaneously release oxidants which can induce middle ear (ME)
epithelial cell damage. Glutathione (GSH), a major extracellular antioxidant in humans,
plays a central role in antioxidant defense. PURPOSE: To evaluate the effects of GSH
treatment on chronic otitis media with effusion (OME). SUBJECTS AND INTERVENTION:
Sixty children with chronic OME were enrolled, 30 of whom were randomly assigned to
the treatment group and 30 to the placebo group. Patients in the treatment group
received 600 mg glutathione in 4 mL saline per day subdivided into five 2-minute
administrations given by nasal aerosol every 3 or 4 waking hours for 2 weeks. Patients
in the control group received 4 mL saline per day following the same procedure as for
GSH treatment. RESULTS: Three months after therapy improvement had occurred in
66.6% of patients in the GSH-treated group and in 8% of the control subjects (P