Autism Studies and Related Medical Conditions, January 2009 - TACA

8- Aluminum Toxicity – 19 citations
1: J Alzheimers Dis. 2006 Nov;10(2-3):179-201.
Aluminum and Alzheimer's disease: a new look.
Miu AC, Benga O.
Program of Cognitive Neuroscience, Department of Psychology, Babeş-Bolyai
University, Cluj-Napoca, CJ, Romania. AndreiMiu@psychology.ro
Despite the circumstantial and sometimes equivocal support, the hypothetic
involvement of aluminum (Al) in the etiology and pathogenesis of Alzheimer's
disease (AD) has subsisted in neuroscience. There are very few other examples of
scientific hypotheses on the pathogenesis of a disease that have been revisited
so many times, once a new method that would allow a test of Al's accumulations in
the brain of AD patients or a comparison between Al-induced and AD
neuropathological signs has become available. Although objects of methodological
controversies for scientists and oversimplification for lay spectators, several
lines of evidence have strongly supported the involvement of Al as a secondary
aggravating factor or risk factor in the pathogenesis of AD. We review evidence
on the similarities and dissimilarities between Al-induced neurofibrillary
degeneration and paired helical filaments from AD, the accumulation of Al in
neurofibrillary tangles and senile plaques from AD, the neuropathological
dissociation between AD and dialysis associated encephalopathy, and the
epidemiological relations between Al in drinking water and the prevalence of AD.
We also critically analyze the prospects of Al-amyloid cascade studies and other
evolving lines of evidence that might shed insights into the link between Al and
AD. The message between the lines of the following article is that the
involvement of Al in the pathogenesis of AD should not be discarded, especially
in these times when the amyloid dogma of AD etiology shows its myopia.
Publication Types:
Historical Article
Review
PMID: 17119287 [PubMed - indexed for MEDLINE]
2: J Alzheimers Dis. 2006 Nov;10(2-3):223-53.
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected
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