Autism Studies and Related Medical Conditions, January 2009 - TACA

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75. Singh VK, Jensen RL. Elevated levels of measles antibodies in children with autism. Pediatr Neurol. 2003 Apr;28(4):292-4. PMID: 12849883 "Virus-induced autoimmunity may play a causal role in autism. To examine the etiologic link of viruses in this brain disorder, we conducted a serologic study of measles virus, mumps virus, and rubella virus. Viral antibodies were measured by enzyme-linked immunosorbent assay in the serum of autistic children, normal children, and siblings of autistic children. The level of measles antibody, but not mumps or rubella antibodies, was significantly higher in autistic children as compared with normal children (P = 0.003) or siblings of autistic children (P
in autistic children. In this current study, we examined associations between virus serology and autoantibody by simultaneous analysis of measles virus antibody (measles-IgG), human herpesvirus-6 antibody (HHV-6-IgG), anti-MBP, and anti-NAFP. We found that measles-IgG and HHV-6-IgG titers were moderately higher in autistic children but they did not significantly differ from normal controls. Moreover, we found that a vast majority of virus serology-positive autistic sera was also positive for brain autoantibody: (i) 90% of measles-IgG-positive autistic sera was also positive for anti- MBP; (ii) 73% of measles-IgG-positive autistic sera was also positive for anti-NAFP; (iii) 84% of HHV-6-IgG-positive autistic sera was also positive for anti-MBP; and (iv) 72% of HHV-6-IgG-positive autistic sera was also positive for anti-NAFP. This study is the first to report an association between virus serology and brain autoantibody in autism; it supports the hypothesis that a virus-induced autoimmune response may play a causal role in autism." vMV, MV & immunity 78. Hussey GD et al. The effect of Edmonston-Zagreb and Schwarz measles vaccines on immune response in infants. J Infect Dis. 1996 Jun; 173(6): 1320-6 PMID: 8648203 The effects of measles immunization on immune responses in infants and the roles of vaccine strain and age of immunization are not known. Eighty-eight children were immunized at 6 or 9 months of age with the Edmonston-Zagreb (EZ) or Schwarz (SW6, SW9) strain of measles vaccine… Therefore, measles immunization resulted in suppression of lymphoproliferation, which was most evident in infants with the highest antibody responses and most immune activation." 79. Auwaerter PG et al. Changes within T cell receptor V beta subsets in infants following measles vaccination. John Hopkins University School of Medicine, Baltimore, MD 21287, USA. Clin Immunol Immunopathol 1996 79(2): 163-70. PMID: 8620622 "Measles produces immune suppression which contributes to an increased susceptibility to other infections. These data suggest that [vaccinal and wild-type] measles virus may affect immune responses in part by altering the T cell receptor repertoire." 80. Schneider-Schaulies S, ter Meulen V. Triggering of and interference with immune activation: interactions of measles virus with monocytes and dendritic cells. Viral Immunol. 2002;15(3):417-28. PMID: 12479392 81. Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells. J Exp Med 1997;186:813-23 82. Sonoda S, Nakayama T. Detection of measles virus genome in lymphocytes from asymptomatic healthy children. J Med Virol 2001 65(2):381-7 PMID: 11536248 Autism Studies & Related Medical Conditions – TACA © Page 323
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Autism Studies & Related Medical Co
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Values of free and total carnitine
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observation suggests that certain m
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with autism. These data suggest tha
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Markers rs2056202 and rs2292813 wer
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2- Autism and Gastrointestinal Infl
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than in nondisease controls (p
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Buie, T. M. (2005). "Gastroesophage
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control children and significant nu
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Horvath, K. and J. A. Perman (2002)
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components indicates a role of NFH
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patients with Crohn disease, one of
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analyzed by a registered pediatric
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oligonucleotide probes targeting pr
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would be effective in alleviating c
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demonstrate a focal CD8-dominated g
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Chlamydia pneumoniae and Streptococ
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vaccine (MCV), and once-exposed chi
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Wakefield, A. J., S. H. Murch, et a
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Walker SJ, Hepner K, Segal J, Krigs
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R, Maisawa S, Miki K. Guidelines fo
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approximately 73 and 37kDa in plasm
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Cook, E. H., Jr., B. D. Perry, et a
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evealed, that AAb level may serve a
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findings, which consisted of obstru
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angiography was performed in all fo
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matched non-autistic siblings had d
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Todd, R. D. and R. D. Ciaranello (1
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eaction was further confirmed by DO
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asic protein (MBP) and glial acidic
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exhibit higher than average levels
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Feasby, T., B. Banwell, et al. (200
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each group participated. Observatio
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Rossignol, D. A., L. W. Rossignol,
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Tsuru, T., M. Mori, et al. (2000).
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Anderson, M. P., B. S. Hooker, et a
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continue. The documented prevalence
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contributing factors may contribute
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Chauhan, V., A. Chauhan, et al. (20
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and folate-dependent methionine syn
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confirmed would indicate that autis
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differed significantly in the patie
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end products (AGE's) in autism brai
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cells in area 22 (p
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nutritional, and toxic status in au
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increase in autism in the last deca
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morphological, genetic and animal m
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Rossignol, D. A. (2007). "Hyperbari
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conditions have demonstrated improv
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not been investigated yet, several
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positively correlated in the autist
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abnormalities are present in brain,
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(tetrahydrobiopterin) were selected
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7 - Autism & Infection - 22 citatio
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micro-organisms. The faecal flora o
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Research Support, U.S. Gov't, P.H.S
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presentation of this syndrome among
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disorder. Yamashita Y, Fujimoto C,
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chronic infection may predispose to
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Streptococcus group A. Vojdani A, C
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provides a detailed analysis of a n
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PMID: 16897390 [PubMed - indexed fo
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syndrome and substance abuse, and a
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to contribute to metal-induced neur
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School of Medical Sciences, Tottori
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Review PMID: 16198633 [PubMed - ind
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diseases in humans. Zinc is redox-i
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Office of Vaccines Research and Rev
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into ferritin or heme. It is not ye
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9 - Dietary Intervention Studies -
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different peptidases resulting in a
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Mechanisms of non-IgE mediated adve
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Reichelt KL, Knivsberg AM.: Can the
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observations is the opioid-excess t
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Patients with gluten ataxia have an
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Hadjivassiliou M, Grunewald RA, Law
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Carroccio A, Montalto G, Custro N,
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Alberti A, Pirrone P, Elia M, Warin
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Thus, a number of milk protein frag
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Abstract: Institute ofPediatrics, L
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Abstract: Service de Psychopatholog
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times peer week) was effective in i
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Reichelt K.L., Knivsberg A.M., Lind
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terminal tetrapeptides into the lef
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Considerable clinical evidence sugg
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material of the P2 fractionation st
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Huebner FR, Lieberman KW, Rubino RP
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Four aspects of clinical evidence f
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Dohan FC: Wheat "consumption" and h
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from 24 children with autism from o
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matched control group. There was a
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administration on certain disorders
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Coleman M, Steinberg G, Tippett J,
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Dolske MC, Spollen J, McKay S, Lanc
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and myo-inositol (-13%) concentrati
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cobalamin. This was associated with
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(significantly lower ratio of SAM t
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Fifty-three controlled trials of th
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PMID: 6765503 [PubMed - indexed for
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Liebscher DH, Liebscher DE. About t
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from patients were examined at outs
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National College of Naturopathic Me
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OBJECTIVE: Ionic magnesium (Mg(2+))
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Pfeiffer CC, Braverman ER. Zinc, th
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evidence support a role for omega-3
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PMID: 1307234 [PubMed - indexed for
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scavenge reactive species, then the
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hyperactivity in patients with ADHD
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esponse to folate deprivation. Expr
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improvement may only become apparen
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Walsh WJ, Glab LB, Haakenson ML. Re
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use other internal or external stan
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In contrast, therapy with very high
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increased in affected children comp
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largely unknown, but genetic, envir
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Campbell DB, Sutcliffe JS, Ebert PJ
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OBJECTIVE: Etiologically unexplaine
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globulin and gamma globulins, IgA,
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Fallon J. Could one of the most wid
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Th1-like (IL-2, IFN-gamma) and Th2-
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Jyonouchi H, Geng L, Ruby A, Reddy
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that may be partly associated with
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Department of Neurology, University
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Mehler MF, Kessler JA. Cytokines in
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Niehus R, Lord C. Early medical his
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Pletnikov MV, Jones ML, Rubin SA, M
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Silva SC, Correia C, Fesel C, Barre
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cytokines were measured using speci
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sera) and cerebellum (9% positive s
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Department of Psychiatry, Indiana U
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(DSM)-IV and the International Clas
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Vojdani A, Campbell AW, Anyanwu E,
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Warren RP, Cole P, Odell JD, Pingre
Page 271 and 272: mechanisms in children with autism.
Page 273 and 274: 12 - Environmental Toxicities (4 ci
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Page 279 and 280: Eye Contact Lens. 2007 Jul;33(4):19
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Page 295 and 296: Mutat Res. 1993 May;287(1):29-46. P
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Page 353 and 354: 199. Stubbs EG et al. Autism and co
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Page 361 and 362: 237. James Neubrander, M.D. -- Bioc
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Page 369 and 370: No Trade Name Sanofi Pasteur, Ltd 0
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Calculating Aluminum in Vaccines He
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16 - How Much Money is Spent on Vac
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consumer information (promotion mat
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evidence to the mercury-vaccine-aut
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More from Verstraeten (Now working
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18 -Difference between Number of Va
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