Autism Studies and Related Medical Conditions, January 2009 - TACA

Reichelt KL, Knivsberg AM.: Can the pathophysiology of autism be explained by the
nature of the discovered urine peptides? Nutr Neurosci. 2003 Feb;6(1):19-28.
Buie T, Winter H, Kushak, R: Preliminary findings in gastrointestinal investigation of
autistic patients. 2002.
Summary:
Harvard University and Mass General Hospital, http://www.ladders.org/autism.php
111 patients evaluated, ages 14 Months to 20 Years, all with GI symptoms of pain or
diarrhea. Endoscopic findings: Esophagitis in 23 (20%), Gastritis in 14 (12%); 4 had
Helicobacter pylori; Duodenitis in 11 (10%); 2 had Celiac Sprue; Eosinophilic
Inflammation in 5 (5%). 10 out of 90 tested (11%) had unusually low enzyme activity:
2 with total pancreatic insufficiency and 5 with multiple enzyme defects. Lactase
deficiency was found in 55% of ASD children tested, and combined deficiency of
disacchraridase enzymes was found in 15%. Enzyme assays correlate well with
hydrogen breath tests. Colitis was found in 11 of 89 patients (12%), none with features
of Ulcerative Colitis or Crohn's. Histologic (biopsy reviewed) lymphoid nodular
hyperplasia was found in 15 of 89 patients (16%). Eosinophilic inflammation was found
in 13 of 89 patients (14%); cause or significance is unclear. Conclusions: more than
50% of autistic children appear to have GI symptoms, food allergies, and maldigestion
or malabsorption issues. We need large, evidence-based studies need to be done in
order to fully understand the gut-brain association in autism.
Krigsman, A, et al: Preliminary data presented at congressional hearing. 2002 Jun.
Summary:
New York University School of Medicine: www.med.nyu.edu
We examined 43 patients with autism, in whom we demonstrated enterocolitis in 65%
and terminal ileal LNH in 90%. As of November, 2002, our total patient population now
stands at 82, and the percentages of enterocolitis and LNH are essentially unchanged.
Additional studies will follow.
Gluten- and casein-free diets for autistic spectrum disorder. Cochrane Database
Syst Rev. 2004;(2):CD003498.
Millward C, Ferriter M, Calver S, Connell-Jones G.
BACKGROUND: It has been suggested that peptides from gluten and casein may have a
role in the origins of autism and that the physiology and psychology of autism might be
explained by excessive opioid activity linked to these peptides. Research has reported
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