Autism Studies and Related Medical Conditions, January 2009 - TACA

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11- Immune Dysregulation in Autism – 71 citations Ahlsen G, Rosengren L, Belfrage M, Palm A, Haglid K, Hamberger A, Gillberg C. Glial fibrillary acidic protein in the cerebrospinal fluid of children with autism and other neuropsychiatric disorders. Biol Psychiatry. 1993 May 15;33(10):734-43. Department of Child Neuropsychiatry, University of Göteborg, Sweden. The cerebrospinal fluid (CSF) of 47 children and adolescents with autism was analyzed for the contents of two astroglial proteins, the glial fibrillary acidic protein (GFA) and S 100. The results were contrasted with those obtained in similarly aged cases with other neuropsychiatric disorders (n = 25) and in normal children (n = 10). S-100 did not discriminate the groups from each other. However, GFA in autism and autistic-like conditions was at a level almost three times that in the normal group. The results could implicate gliosis and unspecific brain damage in autism. An alternative model would be increased synapse turnover regardless of underlying cause. PMID: 8353169 [PubMed - indexed for MEDLINE] Ashwood P, Anthony A, Pellicer AA, Torrente F, Walker-Smith JA, Wakefield AJ. Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology. J Clin Immunol. 2003 Nov;23(6):504-17. The Inflammatory Bowel Disease Study Group, and Centre for Paediatric Gastroenterology, Royal Free and University College, Medical School, London, United Kingdom. pashwood@ucdavis.edu Inflammatory intestinal pathology has been reported in children with regressive autism (affected children). Detailed analysis of intestinal biopsies in these children indicates a novel lymphocytic enterocolitis with autoimmune features; however, links with cognitive function remain unclear. To characterize further, the nature and extent of this disease we examined the mucosal infiltrate using flow cytometry. Duodenal, ileal, and colonic biopsies were obtained from 52 affected children, 25 histologically normal, and 54 histologically inflamed, developmentally normal controls. Epithelial and lamina propria lymphocyte populations were isolated and examined by multicolor flow cytometry. Adjacent biopsies were assessed by semiquantitative histopathology. At all sites, CD3(+) and CD3(+)CD8(+) IEL as well as CD3(+) LPL were significantly increased in affected children compared with developmentally normal noninflamed control groups (p
increased in affected children compared with both noninflamed and inflamed control groups including IBD, at all sites examined (p
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Autism Studies & Related Medical Co
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Values of free and total carnitine
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observation suggests that certain m
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with autism. These data suggest tha
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Markers rs2056202 and rs2292813 wer
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2- Autism and Gastrointestinal Infl
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than in nondisease controls (p
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Buie, T. M. (2005). "Gastroesophage
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control children and significant nu
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Horvath, K. and J. A. Perman (2002)
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components indicates a role of NFH
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patients with Crohn disease, one of
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analyzed by a registered pediatric
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oligonucleotide probes targeting pr
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would be effective in alleviating c
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demonstrate a focal CD8-dominated g
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Chlamydia pneumoniae and Streptococ
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vaccine (MCV), and once-exposed chi
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Wakefield, A. J., S. H. Murch, et a
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Walker SJ, Hepner K, Segal J, Krigs
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R, Maisawa S, Miki K. Guidelines fo
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approximately 73 and 37kDa in plasm
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Cook, E. H., Jr., B. D. Perry, et a
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evealed, that AAb level may serve a
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findings, which consisted of obstru
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angiography was performed in all fo
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matched non-autistic siblings had d
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Todd, R. D. and R. D. Ciaranello (1
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eaction was further confirmed by DO
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asic protein (MBP) and glial acidic
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exhibit higher than average levels
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Feasby, T., B. Banwell, et al. (200
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each group participated. Observatio
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Rossignol, D. A., L. W. Rossignol,
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Tsuru, T., M. Mori, et al. (2000).
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Anderson, M. P., B. S. Hooker, et a
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continue. The documented prevalence
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contributing factors may contribute
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Chauhan, V., A. Chauhan, et al. (20
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and folate-dependent methionine syn
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confirmed would indicate that autis
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differed significantly in the patie
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end products (AGE's) in autism brai
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cells in area 22 (p
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nutritional, and toxic status in au
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increase in autism in the last deca
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morphological, genetic and animal m
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Rossignol, D. A. (2007). "Hyperbari
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conditions have demonstrated improv
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not been investigated yet, several
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positively correlated in the autist
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abnormalities are present in brain,
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(tetrahydrobiopterin) were selected
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7 - Autism & Infection - 22 citatio
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micro-organisms. The faecal flora o
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Research Support, U.S. Gov't, P.H.S
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presentation of this syndrome among
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disorder. Yamashita Y, Fujimoto C,
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chronic infection may predispose to
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Streptococcus group A. Vojdani A, C
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provides a detailed analysis of a n
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PMID: 16897390 [PubMed - indexed fo
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syndrome and substance abuse, and a
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to contribute to metal-induced neur
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School of Medical Sciences, Tottori
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Review PMID: 16198633 [PubMed - ind
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diseases in humans. Zinc is redox-i
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Office of Vaccines Research and Rev
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PMID: 11746431 [PubMed - indexed fo
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into ferritin or heme. It is not ye
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9 - Dietary Intervention Studies -
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different peptidases resulting in a
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Mechanisms of non-IgE mediated adve
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Reichelt KL, Knivsberg AM.: Can the
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observations is the opioid-excess t
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Patients with gluten ataxia have an
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Hadjivassiliou M, Grunewald RA, Law
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Carroccio A, Montalto G, Custro N,
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Alberti A, Pirrone P, Elia M, Warin
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Thus, a number of milk protein frag
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Abstract: Institute ofPediatrics, L
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Abstract: Service de Psychopatholog
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times peer week) was effective in i
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Reichelt K.L., Knivsberg A.M., Lind
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terminal tetrapeptides into the lef
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Considerable clinical evidence sugg
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material of the P2 fractionation st
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Huebner FR, Lieberman KW, Rubino RP
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Four aspects of clinical evidence f
Page 179 and 180: Dohan FC: Wheat "consumption" and h
Page 181 and 182: from 24 children with autism from o
Page 183 and 184: matched control group. There was a
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Page 187 and 188: PMID: 16581239 [PubMed - indexed fo
Page 189 and 190: Coleman M, Steinberg G, Tippett J,
Page 191 and 192: Dolske MC, Spollen J, McKay S, Lanc
Page 193 and 194: and myo-inositol (-13%) concentrati
Page 195 and 196: cobalamin. This was associated with
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Page 199 and 200: Fifty-three controlled trials of th
Page 201 and 202: PMID: 6765503 [PubMed - indexed for
Page 203 and 204: Liebscher DH, Liebscher DE. About t
Page 205 and 206: from patients were examined at outs
Page 207 and 208: National College of Naturopathic Me
Page 209 and 210: OBJECTIVE: Ionic magnesium (Mg(2+))
Page 211 and 212: Pfeiffer CC, Braverman ER. Zinc, th
Page 213 and 214: evidence support a role for omega-3
Page 215 and 216: PMID: 1307234 [PubMed - indexed for
Page 217 and 218: scavenge reactive species, then the
Page 219 and 220: hyperactivity in patients with ADHD
Page 221 and 222: esponse to folate deprivation. Expr
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Page 225 and 226: Walsh WJ, Glab LB, Haakenson ML. Re
Page 227 and 228: use other internal or external stan
Page 229: In contrast, therapy with very high
Page 233 and 234: largely unknown, but genetic, envir
Page 235 and 236: Campbell DB, Sutcliffe JS, Ebert PJ
Page 237 and 238: OBJECTIVE: Etiologically unexplaine
Page 239 and 240: globulin and gamma globulins, IgA,
Page 241 and 242: Fallon J. Could one of the most wid
Page 243 and 244: Th1-like (IL-2, IFN-gamma) and Th2-
Page 245 and 246: Jyonouchi H, Geng L, Ruby A, Reddy
Page 247 and 248: that may be partly associated with
Page 249 and 250: Department of Neurology, University
Page 251 and 252: Mehler MF, Kessler JA. Cytokines in
Page 253 and 254: Niehus R, Lord C. Early medical his
Page 255 and 256: Pletnikov MV, Jones ML, Rubin SA, M
Page 257 and 258: Silva SC, Correia C, Fesel C, Barre
Page 259 and 260: cytokines were measured using speci
Page 261 and 262: sera) and cerebellum (9% positive s
Page 263 and 264: Department of Psychiatry, Indiana U
Page 265 and 266: (DSM)-IV and the International Clas
Page 267 and 268: Vojdani A, Campbell AW, Anyanwu E,
Page 269 and 270: Warren RP, Cole P, Odell JD, Pingre
Page 271 and 272: mechanisms in children with autism.
Page 273 and 274: 12 - Environmental Toxicities (4 ci
Page 275 and 276: 13 - Thimerosal and Toxicity A comp
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Page 279 and 280: Eye Contact Lens. 2007 Jul;33(4):19
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[Contact allergy to preservatives c
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Marn-Pernat A, Buturović-Ponikvar
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[Thiomersal and immunisations] Weis
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50: The evidence for the safety of
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59: Thimerosal induces DNA breaks,
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68: [Effect of the preservative thi
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PMID: 8699562 [PubMed - indexed for
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Mutat Res. 1993 May;287(1):29-46. P
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Krug HF, Culig H. Mol Pharmacol. 19
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Effect of organic and inorganic mer
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Determination of mercury and organo
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Cytotoxicity of mercurial preservat
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Bourdineaud JP, Bellance N, Bénard
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14: Binstock Citations Controversie
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neurodevelopmental delays, which in
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14. Geier DA, Geier MR. A comparati
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29. Boyd Haley, Ph.D. Reduced Level
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40c. Iacono G et al. Intolerance of
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affected children compared with bot
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"OBJECTIVE: Intestinal pathology, i
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67. Jeff Bradstreet, M.D. A Case-co
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in autistic children. In this curre
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87. Semba RD. Vitamin A and immunit
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"These results suggest that large o
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94. Bluhm DP, Summers RS. Plasma vi
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neonatal gut is different from that
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108. Thony B et al. Tetrahydrobiopt
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"Six chemicals, 2-halopropionic aci
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immunological functions in diseases
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[Note etiologic connection with thi
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149. Magazzu G, Scoglio R. Gastroin
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clinical presentations make celiac
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169a. Hadjivassiliou M et al. Does
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174. Headache and CNS white matter
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histology is difficult to interpret
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(n=25): marked 4%, moderate 28%, sl
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199. Stubbs EG et al. Autism and co
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205. Gill HS, Guarner F. Probiotics
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patients with IBS. Since the fermen
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demonstrate that probiotics possess
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237. James Neubrander, M.D. -- Bioc
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significantly more frequent in pati
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aseline. Physicians reported qualit
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http://www.publichealthreports.org/
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No Trade Name Sanofi Pasteur, Ltd 0
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Influenza, live FluMist MedImmune V
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Calculating Aluminum in Vaccines He
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16 - How Much Money is Spent on Vac
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consumer information (promotion mat
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evidence to the mercury-vaccine-aut
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More from Verstraeten (Now working
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18 -Difference between Number of Va
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