Autism Studies and Related Medical Conditions, January 2009 - TACA

and Tyr-Gly-Gly-Trp, which were named gluten exorphins A5, A4, B5 and B4,
respectively. The gluten exorphin A5 sequence was found at 15 sites in the primary
structure of the high molecular weight glutenin and was highly specific for deltareceptors.
The structure-activity relationships of gluten exorphins A were unique in that
the presence of Gly at their N-termini increased their activities. Gluten exorphin B5,
which corresponds to [Trp4,Leu5]enkephalin, showed the most potent activity among
these peptides. Its IC50 values were 0.05 microM and 0.017 microM, respectively, on
the GPI and the MVD assays.
Shattock P. Kennedy A, Rowell F, Berney T: Role of neuropeptides in autism and
their relationships with classical neurotransmitters. Brain Dysfunct 1990, 3: 328-346.
[No abstract available]
Reichelt K.L., Ekrem J., Scott H.: Gluten, milk proteins and autism: Dietary
interventions effects on behavior and peptide secretion. J Appl Nutrition 1990, 42: 1-11.
[No abstract available]
Marchetti B, Scifo R, Batticane N, Scapagnini U: Immunological Significance of
Opioid Peptide Dysfunction in Infantile Autism. Brain Dysfunction,3: 346-354,1990. [No
abstract available]
Leboyer M, Bouvard MP, Lensing P, Launay JM, Tabuteau F, Arnaud P, Waller
D, Plumet MH, Recasens C, Kerdelhue B, Dugas M, Panksepp J: Opioid Excess
Hypothesis of Autism. Brain Dysfunction 1990; 3: 285-298. [No abstract available]
Knivsberg A.M., Wiig K., Lind G., Nodland M., Reichelt K.L.: Dietary intervention
in autistic syndromes. Brain Dysfunc. 1990, 3: 315-327. [No abstract available]
Cade R. et al.: The effects of dialysis and diet in schizophrenia. Psychiatry: A World
perspective 1990, 3: 494-500. [No abstract available]
Barthelemy C, Bruneau N, Adrien J, Roux S, Lelord G: Clinical, Biological and
Therapeutic Applications of the Functional Analysis of Autistic Disorders. Brain
Dysfunction, 3: 271-284, 1990. [No abstract available]
Herrera-Marschitz M, Terenius L, Grehn L, Ungerstedt U: Rotational behaviour
produced by intranigral injections of bovine and human beta-casomorphins in rats.
Psychopharmacology (Berl) 1989;99(3):357-61.
Abstract: Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
The biological activity of beta-casein derived beta-casomorphin peptides was evaluated
by injecting bovine beta-casomorphin-5 (Tyr-Pro-Phe-Pro-Gly), the homologous
sequence in human beta-casein (Tyr-Pro-Phe-Val-Glu) and the corresponding N-
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