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Autism Studies and Related Medical Conditions, January 2009 - TACA

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"In 83 individuals immunized with measles vaccine, the vaccine strain genome was<br />

detected in 10 (71.4%) of 14 recipients whose PBMC were obtained within 2 months of<br />

vaccination."<br />

83. Valsamakis A et al. Strains of measles vaccine differ in their ability to replicate in an<br />

damage human thymus. J Infect Dis. 2001 Feb 1; 183(3): 498-502. Johns Hopkins<br />

University, Baltimore, Maryl<strong>and</strong>, USA. PMID: 11133383<br />

[Question: How would the thymic-damage findings be exacerbated if tested tissues<br />

were selected to represent humans with excessively increased susceptibility, eg, an<br />

infant with persisting colic <strong>and</strong>/or persisting otitis?]<br />

MV & Vitamin A<br />

84. Yalcin SS et al. The effect of live measles vaccines on serum vitamin A levels in<br />

healthy children. Acta Paediatr Jpn. 1998 Aug; 40(4): 345-9. PMID: 9745778<br />

"Serum retinol levels have been shown to be depressed during measles infection. This<br />

study aims to demonstrate whether there is any decrease in serum vitamin A level<br />

following immunization with live viral vaccine <strong>and</strong> its relation with vaccine<br />

seroconversion in children with measles. Since many children receive measles vaccine<br />

alone or in combination with measles-mumps-rubella vaccine, we studied serum vitamin<br />

A levels <strong>and</strong> antibody levels in healthy, well-nourished children before <strong>and</strong> after<br />

immunization with monovalent <strong>and</strong> combined live attenuated measles vaccine…<br />

CONCLUSION: Serum vitamin A levels are reduced following vaccination with<br />

monovalent <strong>and</strong> combined live attenuated measles vaccines."<br />

85. Vitamin A administered with measles vaccine to nine-month-old infants does not<br />

reduce vaccine immunogenicity. J Nutr. 1999 Aug; 129(8): 1569-73. PMID 10419992<br />

http://www.nutrition.org/cgi/reprint/129/8/1569.pdf<br />

"Among malnourished infants, the geometric mean titer was significantly greater in the<br />

vitamin A group compared to the placebo group (ratio of geometric means, 1.57; 95%<br />

confidence interval, 1. 18-2.0), but seroconversion rates did not differ."<br />

[Comment: note the theoretical implication that malourished children may have lower<br />

cell-mediated immunity <strong>and</strong> thus generate increased antibody immunity. This is<br />

consistent with immunity lab-data in many autistic children.]<br />

86. Yalcin SS, Yurdakok K. Sex-specific differences in serum vitamin A values after<br />

measles immunization. Pediatr Infect Dis J. 1999 Aug; 18(8): 747-8. PMID 10462357<br />

<strong>Autism</strong> <strong>Studies</strong> & <strong>Related</strong> <strong>Medical</strong> <strong>Conditions</strong> – <strong>TACA</strong> © Page 324

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