Autism Studies and Related Medical Conditions, January 2009 - TACA

disorder.
Yamashita Y, Fujimoto C, Nakajima E, Isagai T, Matsuishi T.
Department of Pediatrics and Child Health, Kurume University School of Medicine,
Kurume, 830-0011 Japan. yushiro@med.kurume-u.ac.jp
We encountered seven children with symptomatic congenital cytomegalovirus (CMV)
infection from 1988 to 1995, of whom two (28.6%) developed typical autistic
disorder. Case 1: A boy born at 38 weeks' gestation with a birth weight of 3164 g
showed generalized petechiae, hepatosplenomegaly, and positive serum CMV-specific
IgM antibodies. He was profoundly deaf, mentally retarded, and exhibited a lack
of eye contact, stereotyped repetitive play, and hyperactivity. Case 2: A boy
delivered at 39 weeks gestation with a birthweight of 2912 g showed
non-progressive dilatation of the lateral ventricles observed postnatally.
CMV-specific IgM antibodies were positive and CMV-DNA in the urine was confirmed
by PCR. The boy was mentally retarded but not deaf. He showed no interest in
people and delayed speech development. Subependymal cysts were detected by
cranial ultrasound after birth in both patients. This is the first report
describing subependymal cysts and the later development of AD. Cranial magnetic
resonance imaging revealed an abnormal intensity area in the periventricular
white matter suggestive of disturbed myelination; however, no migration disorders
were found in our patients. These findings suggest that the timing of injury to
the developing brain by CMV may be in the third trimester in some patients with
autistic disorder.
Publication Types:
Case Reports
PMID: 12959425 [PubMed - indexed for MEDLINE]
14: Neuropediatrics. 1990 May;21(2):102-3.
Autism as one of several disabilities in two children with congenital
cytomegalovirus infection.
Ivarsson SA, Bjerre I, Vegfors P, Ahlfors K.
Department of Pediatric, University of Lund, Malmö General Hospital, Sweden.
Two children with congenital cytomegalovirus (CMV)-infection, severely disabled
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