Grace Catalog 2008

prep | flash | tlc
Bulk Chromatographic Media Introduction
Grace–The Foremost Name in Silica Materials Science
Davison Chemical, forerunner of the Grace Davison Silica Products business, was founded in Baltimore,
Maryland in 1832. Silica gel, was patented in 1919 and in the early 1920s Davison commercialized silica gel
and began developing many new applications such as air drying, refrigeration, and packaging desiccants.
Grace Davison has continued to expand applications for silica and has long been recognized for superior
technical service, strong applications technology, and global customer support.
Quality, Consistency, and Proven Performance
Grace Davison’s materials science expertise assures highquality
and consistency in its silica-based media products.
Our bulk adsorbents are used to purify a number of FDA
approved biopharmaceuticals and we provide regulatory
support data for GMP applications.
All of our plants are ISO-9001 certified and
our Hesperia, California plant is compliant with
the IPEC-PQG GMP guidelines.
Unmatched Capacity, Global Reach, Expert Support
Our global presence and manufacturing capacity enables us to supply hundreds of tons of silica every year to some of the largest
biotechnology and pharmaceutical manufacturing facilities. When you rely on Grace, you can count on consistent product quality,
timely delivery and expert technical support.
Grace Key Bulk Media Families
Scalable Solutions: Silica and Hardware
Grace manufactures a range of completely scalable silica
media. To help select the appropriate media for your
applicaiton, we describe key media families and highlight
unique phases within these families. Each family highlighted
is available up to ton quantities for process scale applications.
Grace also provides a range of columns and skid systems
from preparative to process scale that ensure optimal
performance of our media (pages 162–174). Please contact
your Grace sales representative to discuss a complete
solution for your preparative or process scale needs.
GraceAlpha
A new silica generation.
GraceAlpha combines increased column efficiencies
and resolution with high loading capacity. A new silica
(patent pending) makes this possible by combining a
high-porosity surface, with a dense core, increasing
mass transfer while yielding a mechanically robust
particle.
Applications: High purity spherical silica suitable for
peptides and small molecules (2000 molecular weight)
Differentiated Phases: C18, C8, C4
Specifications: Spheroidal silica, polymerically and
monomerically bonded, endcapped, 300Å pore size,
10μm–30μm
Formats: Capillary, Microbore, Expedite, Rocket,
Solvent-Reducer, Analytical, Prep, Bulk Media
Davisil ®
Excellent mechanical and structural properties,
Davisil ® silica are globally recognized for their
consistency and reliability.
The Davisil ® silica line offers a range of pore diameters
from 30Å to 2500Å with high surface area and narrow
particle size distributions to offer the chromatographer
the ultimate in selection and performance.
Applications: Economical granular silica for small
molecules to large biomolecules
prep | media
Differentiated Phases: Silica, C18, Cyano, Diol, Amino
Specifications: Granular silica, 30–2500Å pore sizes,
10μm–2000μm particle sizes
Format: Bulk Media
www.discoverysciences.com
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