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MEDICINSKI GLASNIK

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terosalpingografija koja bi evaluirala konačni<br />

učinak terapije.<br />

U Bosni i Hercegovini cervikalne trudnoće,<br />

koje su inače rijetke, tretiraju se medikamentozno<br />

(12). Međutim, medikamentozno liječenje tubarne<br />

trudnoće, kao češće patološke pojave, nije<br />

uobičajeno. S obzirom da se radi o neagresivnoj,<br />

uspješnoj i jeftinoj terapiji, trebala bi se češće<br />

primjenjivati kod pravilno odabranih slučajeva.<br />

Literatura<br />

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A i sur. Porodništvo. Zagreb: Školska knjiga,<br />

1994: 234-41.<br />

2. Čanić T, Ciglar S, Kašnar V. Combined intrauterine<br />

and tubal ectopic pregnancy. Ginecol Clin<br />

Oncol 1997;18: 92-3.<br />

3. Stowall TG, McCord ML. Early pregnancy loss<br />

and ectopic pregnancy. U: Berek JS. Gynecology.<br />

Baltimor: Williams and Wilkins, 1999:487-523.<br />

4. Lavie O, Beller U, Neuman M, Ben-Chentrit A,<br />

Gotteshalk S,Diamant Y. Maternal serum creatinine<br />

kinase: a possible predictor of tubal pregnancy.<br />

Am J Obstet Gynecol 1993; 169:1149–50.<br />

5. Ness R, Mclaughlin M, Heine R, Bass D, Mortimer<br />

L. Fetal fibronectin as a marker to discriminate<br />

between ectopic and intrauterine pregnancies.<br />

Am J Obstet Gynecol 1998; 179:697–702.<br />

6. Kupešić S, Kurjak A. Uloga ultrazvuka u otkrivanju<br />

i liječenju ektopične trudnoće. U: Kurjak A. i<br />

sur. Ultrazvuk u ginekologiji i perinatologiji. Zagreb:<br />

Medicinska naklada, 2007:194-208.<br />

7. Jurković D, Jauniaux E, Kurjak A, Hustin J, Campbell<br />

S, Nicolaides KH, Transvaginal color Doppler<br />

assessment of uteroplacental circulation in<br />

early preganacy. Obstet Gynecol 1991;77:365-9.<br />

8. Shepard RW, Paton PE, Novy MJ, Burry KA. Serial<br />

beta hCG measurments in the early detection<br />

of ectopic pregnancy. Obstet Gynecol 1990,<br />

75:417.<br />

9. Čanić T, Fistonić I. Laporoskopsko liječenje<br />

ektopične trudnoće. Gynecol Perinatol 2008;<br />

17:73-6.<br />

10. Šimunić V. Izvanmaternična trudnoća.U: Šimunić<br />

V i sur. Ginekologija. Zagreb: Naklada Ljevak,<br />

2001:183-94.<br />

11. Bradamante V. Kemoterapijski lijekovi protiv<br />

zloćudnih tumora. U: Medicinska faramakologija.<br />

Zagreb: Medicinska naklada, 1999:471-488.<br />

12. Farquhar MC. Ectopic pregnacy. Lancet; 2005;<br />

366:583-91.<br />

13. Mol BW, Hajenius PJ, Engelsbel S, Ankum WM,<br />

Hemrika DJ, Van der Veen F, Bossuyt PM. Treatment<br />

of tubal pregnancy in The Netherlands: an<br />

economic comparison of systemic methotrexate<br />

administration and Laparoscopic salpingostomy.<br />

Am J Obstet Gynecol 1999; 181:945–51.<br />

14. Sowter M, Farquhar C, Petrie K, Gudex G. A<br />

randomised trial comparing single dose systemic<br />

methotrexate and laparoscopic surgery for the<br />

treatment of unruptured tubal pregnancy. Br J<br />

Obstet Gynecol 2001; 108:192–203.<br />

15. Lipscomb GH, McCord ML, Stovall TG, Huff<br />

G, Portera SG, Ling FW. Predictors of success<br />

of methotrexate treatment in women with tubal<br />

ectopic pregnancies. N Engl J Med 1999;<br />

341:1974–78.<br />

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M. The medical management of ectopic pregnancy:<br />

a meta-analysis comparing “single dose”<br />

and “multidose”regimens. Obstet Gynecol 2003;<br />

101:778–84.<br />

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Chastang C, Philippe HJ, Nisand I. Treating ectopic<br />

pregnancy with the combination of mifepristone<br />

and methotrexate: a phase II nonrandomized<br />

study. Am J Obstet Gynaecol 1998; 179:640–43.<br />

Extrauterine pregnancy treated<br />

with Metrotrexat<br />

Ljiljana Bilobrk Josipović, Branka Lovrinović,<br />

Anton Galić<br />

Department of Obstetric and Gynecology, Croatian Hospital “Dr<br />

Fra Mato Nikolić “ Nova Bila, Bosnia i Herzegovina<br />

ABSTRACT<br />

Case report<br />

In this report we are describing a case of a patient<br />

whose tubal pregnancy was medicated with<br />

metrotrexat. The patient visited gynecologist<br />

10+1 week after the last period, complaining<br />

about mild pain in the lower abdomen area and<br />

scarce vaginal bleeding. After ultrasound and<br />

biochemical markers examinations the extrauterine<br />

(tubal) pregnancy in the right oviduct was<br />

diagnosed. The initial level of β hCG was 5005<br />

mIU/ml and the size of gestational sac was 51<br />

mm x 47 mm with an embryo 5 mm long. The<br />

patient was successfully cured with one 50 mg<br />

ampule of metrotrexat, intramuscularly applied.<br />

Key words: extrauterine pregnency, metrotrexat,<br />

values of β hCG-a<br />

Original submission: 19 March 2009; Revised submission: 20<br />

April 2009; Accepted: 06 May 2009.;<br />

283

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