MEDICINSKI GLASNIK
MEDICINSKI GLASNIK
MEDICINSKI GLASNIK
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196<br />
Medicinski Glasnik, Volumen 6, Number 2, August 2009<br />
Diagnostic value of Interleukin 6 and C-reactive protein from<br />
umbilical cord blood in recognition of early infection in full-term<br />
newborns with low birth weight<br />
Almira Ćosićkić 1 , Fahrija Skokić 2 , Selmira Brkić 3<br />
1 Clinic for children’s diseases, 2 Clinic for gynecology and obstetrics, Department for neonates; University Clinical Center in Tuzla, 3<br />
Depatment of Pathophysiology; Medical Faculty inTuzla,<br />
ABSTRACT<br />
Aim Diagnostic value evaluation of Interleukin-6 (IL-6) and C-reactive protein (CRP) from the umbilical<br />
cord blood in diagnosis of early newborn infection (ENI) on the basis of clinical picture, hematological<br />
parameters and microbiological tests.<br />
Methods A retrospective-prospective study conducted in the Department of Gynecology and Obstetrics.<br />
One hundred and twenty newborns were included in the study. Inclusion criteria were: newborns<br />
with birth weight less than 2500 grams, gestational age from 37 to 42 weeks, both genders, no visible<br />
anomalies at birth, from a single pregnancy. Newborns were divided into two groups: the examined<br />
group, newborns with ENI (n=28), and second, control group of newborns without ENI (n=92). IL-6<br />
and CRP were determined from the umbilical cord blood and clinical picture, hematological parameters<br />
and microbiological test results.<br />
Results IL-6 values of from 0 to 10 pg/ml were considered normal. Median IL-6 value of in the first<br />
group was 49 pg/ml and in the second group 9,7 pg/ml with significant difference between these two<br />
groups (P