Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
En resumen, los autores afirman que el progreso en<br />
el campo de endotipos y fenotipos de OA es<br />
importante para el diseño de tratamientos<br />
efectivos, estratificados, tomando en cuenta el<br />
impacto que la OA posee en el individuo y la<br />
sociedad en el mundo entero.<br />
REFERENCIAS<br />
1.- Chaput JP, Klingenberg L, Astrup A, Sjödin AM. Modern sedentary activities promote overconsumption of food in our current obesogenic environment. Obes<br />
Rev <strong>20</strong>11; 12:e12–e<strong>20</strong>.<br />
2.- Owens C, Conaghan PG. Improving joint pain and function in osteoarthritis. Practitioner <strong>20</strong>16; 260:17–<strong>20</strong>.<br />
3.- Deveza LA, Loeser RF. Is osteoarthritis one disease or a collection of many? Rheumatology <strong>20</strong>18; 57:iv34–iv42.<br />
4.- Loeser RF. Aging and osteoarthritis. Curr Opin Rheumatol <strong>20</strong>11; 23:492 – 496.<br />
5.- Sutton S, Clutterbuck A, Harris P, Gent T, Freeman S, Foster N, et al. The contribution of the synovium, synovial derived inflammatory cytokines and<br />
neuropeptides to the pathogenesis of osteoarthritis. Vet J <strong>20</strong>09; 179:10–24.<br />
6.- Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol <strong>20</strong>10; 6:625 – 635.<br />
7.- Poulet B, Beier F. Targeting oxidative stress to reduce osteoarthritis. Arthritis Res Ther <strong>20</strong>16; 18:32.<br />
8.- Henrotin Y, Sanchez C, Bay-Jensen AC, Mobasheri A. <strong>Osteo</strong>arthritis biomarkers derived from cartilage extracellular matrix: Current status and future<br />
perspectives. Ann Phys Rehabil Med <strong>20</strong>16; 59:145–148.<br />
9.- Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, et al. OARSI FDA <strong>Osteo</strong>arthritis Biomarkers Working Group. Application of biomarkers in<br />
the development of drugs intended for the treatment of osteoarthritis. <strong>Osteo</strong>arthritis Cartilage. <strong>20</strong>11 May;19(5):515-42. doi: 10.1016/j.joca.<strong>20</strong>10.08.019.<br />
10.- Dell'Isola A, Allan R, Smith SL, Marreiros SS, Steultjens M. Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. BMC<br />
Musculoskelet Disord. <strong>20</strong>16 Oct 12;17(1):425.<br />
11.- Pepys MB, Hirsch eld GM. C-reactive protein: a critical update. J Clin Invest <strong>20</strong>03; 111:1805–1812.<br />
12.- Greene MA, Loeser RF. Aging-related inflammation in osteoarthritis. <strong>Osteo</strong>arthr Cartil <strong>20</strong>15; 23:1966 – 1971.<br />
13.- Kjelgaard-Petersen C, Siebuhr AS, Christiansen T, Ladel C, Karsdal M, Bay-Jensen AC. Synovitis biomarkers: ex vivo characterization of three biomarkers for<br />
identification of inflammatory osteoarthritis. Biomarkers <strong>20</strong>15; <strong>20</strong>: 547–556.<br />
14.- Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, et al. Value of biomarkers in osteoarthritis: current status and perspectives. Ann<br />
Rheum Dis <strong>20</strong>13; 72:1756– 1763.<br />
15.- Findlay DM, Kuliwaba JS. Bone-cartilage crosstalk: a conversation for understanding osteoarthritis. Bone Res <strong>20</strong>16; 4:16028.<br />
doi:10.1038/boneres.<strong>20</strong>16.28<br />
16.- Karsdal MA, Leeming DJ, Dam EB, Henriksen K, Alexandersen P, Pastoureau P,et al. Should subchondral bone turnover be targeted when treating<br />
osteoarthritis? <strong>Osteo</strong>arthr Cartil <strong>20</strong>08; 16:638– 646.<br />
17.- Huebner JL, Bay-Jensen AC, Hu man KM, He Y, Leeming DJ, McDaniel GE, et al. Alpha C-telopeptide of type I collagen is associated with subchondral bone<br />
turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis. Arthritis Rheumatol <strong>20</strong>14; 66:2440–2449.<br />
18.- Le Clanche S, Bonnefont-Rousselot D, Sari-Ali E, Rannou F, Borderie D. Inter-relations between osteoarthritis and metabolic syndrome: a common link?<br />
Biochimie <strong>20</strong>16; 121:238–252.<br />
19.- Dell'Isola A, Steultjens M. Classification of patients with knee osteoarthritis in clinical phenotypes: data from the osteoarthritis initiative. PLoS One <strong>20</strong>18;<br />
13:e0191045.<br />
<strong>20</strong>.- Van der Esch M, Knoop J, van der Leeden M, Roorda LD, Lems WF, Knol DL, Dekker J. Clinical phenotypes in patients with knee osteoarthritis: a study in the<br />
Amsterdam osteoarthritis cohort. <strong>Osteo</strong>arthr Cartil <strong>20</strong>15; 23:544– 549.<br />
21.- Hotamisligil GS. Inflammation and metabolic disorders. Nature <strong>20</strong>06; 444:860–867<br />
22.- Saudek DM, Kay J. Advanced glycation endproducts and osteoarthritis. Curr Rheumatol Rep <strong>20</strong>03; 5:33–40.<br />
23.- Zhang W, Likhodii S, Zhang Y, et al. Classification of osteoarthritis phenotypes by meabolomics analysis. BMJ Open <strong>20</strong>14; 4:e006286.<br />
24.- Legrand C, Ahmed U, Anwar A, Rajpoot K, Pasha S, Lambert C, et al. Glycation marker glucosepane increases with the progression of osteoarthritis and<br />
correlates with morphological and functional changes of cartilage in vivo. Arthritis Res Ther <strong>20</strong>18; <strong>20</strong>:131.<br />
25.- Sell DR, Biemel KM, Reihl O, Lederer MO, Strauch CM, Monnier VM. Glucosepane is a major protein cross-link of the senescent human extracellular matrix.<br />
Relationship with diabetes. J Biol Chem <strong>20</strong>05; 280:12310–12315.<br />
26.- Jeon OH, David N, Campisi J, Elissee JH. Senescent cells and osteoarthritis: a painful connection. J Clin Invest <strong>20</strong>18; 128:1229–1237<br />
OSTEO<br />
<strong>360</strong><br />
50<br />
Novedades en patología osteomioarticular