Self-assembled Transition Metal Coordination Frameworks of ...

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C0pper(ll) complexes Table 4.6. Selected bond lengths (A) and bond angles (°) of compound 13a. Cu(lA)—N(lA) Cu(lA)—N(4A) Cu( l A)—Cl( 1 A) N(lA)—N(2A) N(1A)—C(6A) N(2A)—N(3A) N(3A)—C(5A) C(5A)—C(6A) C(6A)—C(7A) Cu(2B)—N(lB) Cu(2B)—N(4B) Cu(2B)—Cl(2B) N(lB)—N(2B) N(1B)—C(6B) N(2B)—N(3B) N(3B)—C(5B) C(5B)—C(6B) C(6B)—C(7B) N(lA’)—Cu(lA)—N(lA) N(lA’)—Cu(lA)—N(4A) 4.4. Anticancer properties 1.996(2) 2.0483(16) 2.6770(13) 1.323(2) 1.351(3) 1.333(2) 1.371(3) 1.410(3) 1.443(3) 1.9876(19) 2.0559(16) 2.6772(14) 1.330(2) 1.365(3) 1.329(2) 1.368(3) 1.416(3) 1.431(3) 180.000(1) 99.96(7) N(lA)—Cu(lA)—N(4A) N(4A)—Cu(lA)—N(4A’) N(lA)—Cu(lA)—Cl(lA’) N(4A)—Cu(lA)—Cl(lA’) N(lA’)—Cu(lA)—Cl(lA) N(lA)—Cu(lA)—Cl(1A) N(4A)—Cu(lA)—Cl(lA) N(4A’)—Cu(1A)-—Cl(lA) Cl(lA’)—Cu(lA)—Cl(lA) N(lB’)—Cu(2B)—N(lB) N(lB)—Cu(2B)—N(4B’) N(lB’)—Cu(2B)—N(4B) N(lB)—Cu(2B)—N(4B) N(4B’)—Cu(2B)—N(4B) N(lB)—Cu(2B)—Cl(2B’) N(4B)—Cu(2B)—Cl(2B’) N(lB’)—Cu(2B)—Cl(2B) N(lB)—Cu(2B)—Cl(2B) N(4B’)—Cu(2B)—Cl(2B) N(4B)—Cu(2B)—Cl(2B) Cl(2B’)—Cu(2B)—Cl(2B) 80.04(7) 180.000(1) 88.56(6) 88.39(6) 88.56(6) 91.44(6) 91 .61(6) 88.39(6) 180.000(1) 180.00(11) 100.07(7) 100.07(7) 79.93(7) 180.000(1) 88.51(6) 88.38(5) 88.51(6) 91.49(6) 88.38(5) 91.62(5) 180.0 Anticancer activity (in vitro) of selected Cu(II) complexes was analyzed by standard growth inhibitory assays. Mechanism of action is analyzed in MCF-7 cell lines and is one of the three cell line panel recommended by NCI (National Cancer Institute) for anticancer drug screening (NCI developmental therapeutic program). Determination of the Effectiveness of the compounds was achieved by MTT Cell Proliferation Assay. The procedures are as reported in Chapter 2. The cell survival of various compounds in different concentration is summarized in Table 4.7. 187
Chapter 4 Table 4.7. Cell survival shown by complexes at different concentration. ll 13 15 16 17 18 Cone. Cell survival shown by 10 uM 51.8 90 68.28 86.25 94.2 66.07 50 uM 69.38 88.43 84.14 80.31 83.56 76.79 100 pM 89.79 76.875 94.71 79.68 72.67 89.57 A graph plotted taking the concentration of the compound (X-axis) against the percentage viability (Y-axis) is given in Fig 4. 59. vi L 120 \O— in 40 20f t xo “"‘°‘°N\ so
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7,2/H5 Self-assembled Transition Me
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, Phone orr. 0484-2575804 ; Phone R
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‘ilC7(,'NO’WLQ'I(D QEMEWT In tl
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PREFACE In its method, chemistry is
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CONTENTS CHAPTER 1 Introduction to
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4.3.5. Magnetochemistry 4.3.6. Char
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Chapter I__ _ _ irreducible, is a n
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Chapter I W 7 _ W _ 7 pg _ jg to pr
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Chapter I H_ g g 7 g 7 7 __ harvest
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Chapter I _ _ ______g__H _ g involv
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Chapter I _ g plays a pivotal role
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Chapter I g g _ exhibit considerabl
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Chapter I _, assemblies to generate
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Chapter I _ ,_ of mono or dinuclear
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Chapter I M W 7 7 _ __ 1.3.1.1. Ant
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Chapter I _ _ _ _ \_ 4- Jm _. _.
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Chapter In g_ g _ E __ _ E __( > es
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Chapter I W__‘ _ 1.6.6. MALDI MS
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Chapter I ,,_ g electron spin (the
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Chapter I W _ _ Traditional magnets
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Chapter I L.K. Thompson, O. Waldman
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Chapter I i __ _ Org. Chem. 31 (200
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Chapter In _g , g H g 85. S. Padhye
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Chapter 2 1 g anticipation of Cu(H)
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Chapter 2 _. M_ _ up 1. Quinoline-2
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Chapter 2 chloroform solution and d
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Chapter2 V _ _ _ _, 7 _ with aceton
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Chapter 2 _ 7 f __ i 2.3. Results a
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100s0- I > J 20
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— — 1 Ligands 1
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Ligands The ‘H and "C NMR spectra
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Ligands The ‘H NMR spectrum of HZ
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M1 1‘ 11 IL; Fig. 2.11. 'H NMR sp
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' | Ligands uo no 1&0 150 no no no
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Ligands Table 2. 3. Crystal data an
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Ligands The C-S bond distances of 1
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ligands between the planes of Cg(2)
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" F Ligands A indicates a typical d
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' ' Q 0' ¢ ¢" .~ 0~ I Q Q Q \ ' Q
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2.4.2. M TT Cell Proliferation Assa
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Table 2.9. Cell proliferation effec
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7 y _ i _ W Ligands B. Moubaraki, K
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CHAPTER Ni(II) complexes of carbohy
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_ _ __ g_ g W g H__ Ni(ll) complexe
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_ g A __ Ni(lI) complexes The reddi
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3.3. Results and discussion g_g _ N
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3.3.1. MALDI MS spectral studies of
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Ni(Il) complexes In the case of com
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100 U-
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3.3.2. IR and electronic spectral s
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Chapter 3 The electronic spectra of
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t§hqphw*3 v(Ni—S), further suppo
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Chapter 3 charge transfer bands. Fo
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Chapter 3 were refined anisotropica
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Chapter 3 3.3.3.1. Crystal structur
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Chapter 3 Table 3.7. Selected bond
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Chapter 3 N(l3)—C(35), N(2l)-C(58
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3.3.3.2. Crystal structures 0f[Ni(H
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Table 3.10. Selected bond lengths (
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Ni(lI) complexes significant 1t---1
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3.3.4. Magnetochemistry of the mole
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Ni(Il) complexes The allowed values
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in xn In
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g 7 Ni(Il) complexes 3.4. Concludin
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11 12 13 14 15 16 17 18 19 20 21 22
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41 42 43 44 45 46 47 48 49 50 51 52
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_ g “FOUR CHAPTER Cu(II) complexe
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_g C0pper(II) complexes complex of
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_ _ , p f 7, Copper-(II) complexes
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pp g _g _4_,_ C0pper(II) complexes
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g _,_,_ g g Copperfll) complexes in
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i ____ 3+ i --—- C 0pper(H) 2+ co
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Page 154: C0pper(lI) complexes confirm the po
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Page 160 and 161: C0pper(1l) complexes state, similar
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Page 181 and 182: Chapter 4 The solid state and some
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Page 212 and 213: Manganese(Il) complexes lcmzmoll in
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Page 216 and 217: Manganese(II) complexes MALDI MS sp
Page 218 and 219: 5.3.2. EPR spectral studies Mangane
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Page 231 and 232: Chapter 5 To fit and interpret the
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1 | Chapter 6 100m__ ‘ 76$ mi, 16
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3 - i El Q I Chapter 6 - '3“ 1999
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Chapter 6 The compound 27 exhibits
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(T71aq7tew'¢5 centered at 1711.9 c
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1 . 1 Chapter 6 1244 100--1-; 1245
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Chapter 6 6.3.2. Electronic and IR
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Chapter 6 band at 19160 and 23920 c
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Zinc(II) & Cadmium(II) complexes Th
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.- 60- I ‘J TZinc(Il) & Cadmium(l
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Zinc(Il) & Cadmium(Il) complexes re
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Zinc(II) & C admium(ll) complexes T
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Fig. 6.25. The molecular structure
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Zinc(lI) & Cadmium(ll) complexes Al
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Zi!lC(II) & Cadmlum(II) C0mlexes Ta
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V _ i Zinc(1I) & Cadmium(lI) comple
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_ g _ g g V Zinc(lI) & Cadmiumfll)
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_, _ g pg L Summary and conclusion
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W g _ g mm Summary and conclusion a
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__ ,_ _ W A _ _ Summary and conclus
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Curriculum Vitae PERSONAL PROFILE N
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2-Hydroxyacetophenone 4-phenylthios
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