Self-assembled Transition Metal Coordination Frameworks of ...

Chapter 2 W _ _
thiocarbohydrazide moiety in HZL3 and N—N, N—C and the C=O bond distances of the
carbohydrazide moiety in H2L4 suggest extensive electron delocalization of the whole
thiocarbohydrazone and carbohydrazone moieties. The thiocarbohydrazones and
carbohydrazones, H2L', HZL3, HZL4 and H2L°, were tested for in virro anticancer
properties and they show cell proliferation effect, but antiproliferation effect was
observed for the thiosemicarbazone HL7.
A survey of the literature showed that the carbohydrazones and
thiocarbohydrazones are not well studied like semicarbazones and
thiosemicarbazones. Of these, the carbohydrazones are scantly studied compared to
thiocarbohydrazones. Also, the coordination chemistry of suitable carbohydrazones
for self-assembly frameworks is not known so far. Various coordination compounds
of these typically interesting organic compounds, both carbohydrazones and
thiocarbohydrazones, are yet to be explored and obviously we expect such materials
would find applications in various fields of science and technology.
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