Self-assembled Transition Metal Coordination Frameworks of ...

Chapter 4 _ g g ,4 pp if
magnetic studies. This is attributed to the labiality of carbohydrazone and
thiocarbohydrazone copper complexes in DMF at low concentrations. The MALDI
MS spectra also reveal that the compounds are not very stable in solution or under
ionization conditions of MALDI. However a detailed study in connection with EPR
and magnetism of carbohydrazone and thiocarbohydrazone derived Cu(lI) complexes
is still to come and is open for further research.
An unusual complex [Cu(L4“)2Cl2]- CH3OH- H2O- H,o*c1" (13a) isolated
from a solution of 13 in methanol on exposure to air and characterized with single
crystal X-ray diffraction study. It is found to be formed by degradation of —CO— group
and cyclization of ligand unit of 13. Based on the UV spectral follow up as a function
of time, intensity loss of bands corresponding to O—>Cu(ll) charge transfer is
confirmed for complex 13. This is attributed to the degradation of —CO— group. The
complex 13a is found to be having an octahedral Cu(II) center.
As a preliminary application study we have screened selected Cu(lI)
complexes for in vitro anticancer activity in MCF-7 cell lines. The activities of
complexes are found different from their corresponding free ligands. Three complexes
13, 16 and 17 are reported as anticancer gadgets against breast cancer. The complexes
show antiproliferation effect, though their corresponding free ligands showed cell
proliferation. The Cu(II) complexes derived from a carbohydrazone ligand l,5-bis(di­
2-pyridyl ketone) carbohydrazone HZL4 are found to exhibit better activities. The
present chapter is thus reported as a beginning to explore novel anticancer compounds
of potential class of carbohydrazone ligands.
References
l. B.J. Hathaway, D.E. Billing, Coord. Chem. Rev. 5 (1970) 143.
2. M.-T. Youinou, N. Rahmouni, J. Fischer, J. A. Osborn, Angew. Chem. lnt.
190