Self-assembled Transition Metal Coordination Frameworks of ...

Table 2.9. Cell proliferation effect of compounds used.
Concentration
HI.’
% cell
H2L‘
proliferation
H21.’ H21.‘
of
H2L6
-u-I
10 um 73.35 82.76 85.66 Q98.74 87.74
100 |.1M 70.06 94.55 97.79 103.99 99.84
120 ­
_4
80 l
'=- 60 ~
'40
20w
Om ___ .*
10 microM 100 microM
Concentration
|l in.’ I H21} U 11,1.’ El n,L‘ I Hm‘,
Fig. 2.21. Cell proliferation effect of compounds used at different concentration.
2.5. Concluding remarks
Ligands
We have synthesized and physico-chemically characterized three
carbohydrazones and three thiocarbohydrazones along with two thiosemicarbazones.
All the thiocarbohydrazones and carbohydrazones possess two or more binding units
and are capable of forming mono and dinuclear compounds in addition to serve as
building blocks for tetranuclear molecular square grids. All the thiocarbohydrazones
and carbohydrazones are found in the thione tautomeric form in the solid state. It is
found that the compounds HZLZ and HZLS exhibiting keto-enol tautomerism, while the
compound I-IZLI shows an exclusive presence of its thione tautomer in their CDC];
solutions. Single crystal X-ray diffraction studies of HQL3 and HZL4 are carried out,
which support the spectral data. The N—N, N—C and the C=S bond distances of the
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