14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 27.032 Session: HIV: Epidemiology and Prevention Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Molecular epidemiology of HIV-1 in newly-diagnosed treatment-naïve patients in Singapore Y.-J. Sun 1 , P. Kaur 1 , Y. S. Leo 2 1 Tan Tock Seng Hospital, Singapore, Singapore, 2 Communicable Disease Centre, Tan Tock Seng Hospital, Singapore, Singapore Background: The molecular epidemiology of HIV-1 has not been well studied in Singapore. Information on HIV-1 molecular epidemiology obtained from previous studies was either based on a small sample size or on a specific HIV-1 population (seroconverters). In this study we aimed to have a better understanding to HIV-1 molecular epidemiology in newly-diagnosed treatmentnaïve patients on the basis of a larger sample size. Methods: Newly-diagnosed treatment-naïve HIV-1 patients were prospectively, consecutively recruited from the Communicable Disease Centre, Tan Tock Seng Hospital, Singapore. PCR products of pol gene that encompass the entire protease gene and two-third of the reverse transcriptase (RT) gene were amplified based on PBMC-associated viruses using an in-house method. Direct sequencing was used to sequence the pol gene PCR products. The pol sequences were used for phylogenetic analysis and for genotypic analysis of drug resistance. Results: One hundred fifty-one patients were analyzed in this study. Of whom 92% (n=139) were men, 49.7% (n=75) were men who have sex with men (MSM), and 49% (n=74) were heterosexuals. Five HIV-1 subtype/CRF were identified, including CRF01_AE (n=94, 62.3%), subtype B (n=53, 35.1%), CRF33_01B (n=3, 2%), and one each of CRF34_01B and CRF07_BC. MSM accounted for 35.1% (n=33) of the CRF01_AE infections and 77.4% (n=41) of the subtype B infections. Phylogenetic analysis showed that 55.3% (n=52) of 01_AE sequences were clustered in each of 8 clusters and 73.6% (n=39) of subtype B sequences were clustered in each of 5 clusters; in addition, MSM was more common in one of the clusters compared to heterosexuals in both 01_AE clusters (55.7% vs. 37.7%, OR 11.9, 95% CI 3.9-36.7) and subtype B clusters (87.8% vs. 25%, OR 21.6, 95% CI 4.6-101.5). There was no any known drug-resistant mutation was detected by direct sequencing. Conclusion: CRF01_AE and subtype B remain the primary etiology for HIV-1 infections in Singapore. The high extent of clustering of MSM suggests active transmission of HIV-1 in this specific population, and therefore, more effective prevention intervention measures for HIV-1 transmission are needed for this group of individuals.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 27.033 Session: HIV: Epidemiology and Prevention Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Factors influencing access to HIV care services by clients referred from a district home based HIV counseling and testing program in eastern Uganda, 2009 D. Lubogo 1 , H. Wamani 1 , J. Ddamulira 2 , R. Tweheyo 3 1 Makerere University School of Public Health, Kampala, Uganda, 2 Makerere University School of Public Health, UGANDA, Kampala, Uganda, 3 Makerere University School of Public Health, Kampala, Kampala, Uganda Background: Between 2006 and 2008 only 64.6% of all HIV positive referrals from the Home Based HIV Counselling and Testing (HBCT) program in Kumi district of Eastern Uganda accessed HIV care services at health facilities. This study to determined the factors influencing access to HIV care services for clients referred in the district Methods: We conducted a descriptive, cross-sectional study in February 2009. The study population comprised of HIV positive adults aged 18 years identified by the district HBCT program and referred to public and private health facilities for HIV care services. We administered face-to-face interviews to 352 respondents using a semi-structured questionnaire. Respondents were selected by systematic random sampling using a sampling interval of 15 out of 5044 HIV positive clients identified in the HBCT program. The main outcome measure was access to HIV care defined as access to Cotrimoxazole prophylaxis in the facility HIV program. Data was entered in Epi-Info version 3.5.1 and analyzed using Stata/SE 10.0. Logistic regression analysis was done and the level of significance used was p
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