14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 28.004 Session: Influenza Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Novel influenza A H1N1 infection among healthcare workers M. QUERCI, F. HERRERA, E. TEMPORITI, W. ALCALA, L. FIGUERAS, F. BARBERIS, G. CARBALLAL, M. ECHAVARRIA, M. STRYJEWSKI, P. BONVEHI CEMIC, BUENOS AIRES, Argentina Background: Knowledge of epidemiological, clinical characteristics and outcomes in healthcare workers (HCW) exposed to novel Flu A H1N1 could be useful in order to improve protection measures. Methods: A longitudinal study was carried out at CEMIC among 1,465 HCW from June-July, 2009. Those with influenza like illness (ILI) were swabbed for detection of novel Flu A H1N1 virus by RT-PCR. Fisher’s exact test or Wilcoxon were employed. Logistic regression (LR) model to identify variables associated with H1N1 virus were analyzed. Results: HCW with ILI n = 85 H1N1 positive n=43 (%) H1N1 negative n=42 (%) Female 26 (60) 24 (57) 0.83 Age, mean (±SD) 33.4 (9 ) 34.1 ( 9) 0.72 Nurse or physician 33 (77) 31 (74) 0.81 Comorbidities 6 (14) 7 (17) 0.77 Contact with suspected/ confirmed case 30 (70) 35 (83) 0.20 Use of adequate protection measures 28 (65) 26 (62) 0.82 Flu vaccination † 32 (76 ) 32 (78) 1.0 Fever 37 (86) 34 (81) 0.57 Asthenia 31 (72) 02 (48) 0.03 Cough 34 (79) 18 (43) 0.008 Diarrhea 4 (9) 12 (29) 0.03 Complications 5 (12) 4 (9.5) 1.0 Pneumonia 2 (5) 1 (2) -- Oseltamivir Prophylactic 2 (5) 13 (31) 0.002 Therapy 41 (95) 36 (86) 0.16 Days of oseltamivir, median (IQR) 5 (5-5) 5 (3-5) 0.002 Adverse events with oseltamivir 12 (28) 8 (19) 0.44 Days off, median (IQR) † 7 (5-7) 4 (2-6.5) 0.0004 Hospital admission 1 (2.33) 0 1.0 Death 0 0 -- † In 94/96 HCW. LR with H1N1 as dependent variable showed: cough (OR 6.93; 95%CI 2.24, 21.4); prophylactic oseltamivir (OR 0.08; 95% CI 0.01, 0.43); and diarrhea (OR 0.17; 95% IC 0.04, 0.74). Conclusion: Incidence and complications of ILI was low among HCW. Seasonal flu vaccination seems to give low protection against pandemic strain. Prophylactic oseltamivir was associated with decreased risk of H1N1 infection. p
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 28.005 Session: Influenza Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Demographic and epidemiological characteristics of influenza in HIMA, San Pablo Caguas Hospital, Puerto Rico M. Collado, L. Collado, C. Cortes HIMA San Pablo Caguas Hospital, 00725, PR, USA Background: On 24 April 2009, the World Health Organization (WHO) informed of an epidemic caused by a novel influenza A/H1N1 originating from Mexico. On 25 May 2009, Puerto Rico confirms its first case. About a month later, 11 July 2009, WHO declares a worldwide pandemic (phase 6), but not before Puerto Rico reports its first death on 15 June 2009. Nevertheless, after results of submitted specimens were reported from CDC, HIMA•San Pablo Caguas Hospital received its first positive confirmation for influenza H1N1 from a specimen collected on May 23, 2009. The purpose of this presentation is to assess the emergence and characteristics of influenza A/H1N1; specifically focused in HIMA•San Pablo Caguas Hospital. The correlation between severity of illness and clinical outcome will be analyzed in cases admitted to ICU. We will also determine the distribution among demographical characteristics, such as age, gender, and locality. Epidemic curve of collected specimens (n=379) of influenza A/H1N1 by date of symptom onset, 26 April 2009 to 14 September 2009. Methods: Clinical specimens, oral pharyngeal and/or blood, were collected and tested using rRT- PCR, rapid antigen testing, or influenza titers from April 26 2009 to September 14, 2009. Results: Influenza A, B, and both A and B viruses were identified in 47, 6 and 3 of the Oseltamivir-treated population (n=375), correspondingly. Less often associated with laboratoryconfirmed cases of influenza A/H1N1, were the incidence of mortality in obstetrical cases. Of the 379 confirmed and probable cases of influenza A/H1N1, 2.6% and 8.7% were reported as deceased and pregnant, respectively. Among the 379 clinically suspected cases for influenza H1N1, only 3 were confirmed by RT-PCR sent to the Centers for Disease Control and Prevention in Atlanta. The median age for the 79 confirmed cases for influenza A and/or B was 18 years (range, 6 month to 65 years) with a female prevalence of 63%. Complicated cases of probable and/or confirmed influenza A/H1N1 were admitted to the intensive care unit of which 5 patients (6%) died. Reported cases of Influenza-like illness tested with RT-PCR (n=119) Conclusion: This was an observational study demonstrating demographic and epidemiological information of influenza in HIMA•San Pablo Caguas Hospital.
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