14th ICID - Poster Abstracts - International Society for Infectious ...

When citing these abstracts please use the following reference:
Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number.
Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1
is available electronically on http://www.sciencedirect.com
Final Abstract Number: 30.022
Session: Mycology, Fungal Infections and Antifungal Drugs
Date: Wednesday, March 10, 2010
Time: 12:30-13:30
Room: Poster & Exhibition Area/Ground Level
Type: Poster Presentation
Clinical analysis of 92 patients with Fungaemia - data from national survey in Slovakia
L. Drgona 1 , J. Trupl 2 , H. Hupkova 3
1 Comenius University and National Cancer Institute , Bratislava, Slovakia, 2 AlphaMedical s.r.o.,
Bratislava, Slovakia, 3 Comenius University, Bratislava, Slovakia
Background: A prospective national survey on fungaemia was done during 2005-2007 in
Slovakia. The increasing incidence of fungaemia and candidaemia was documented (2.57 and
2.16/100.000/year, respectively) comparing previous survey. 38% of cases of candidaemia were
caused by C. albicans and 62% by non-albicans strains.
Methods: 92 episodes in 92 patients with fungaemia and available clinical data were analysed
according to data from CRFs. Informations about risk factors, antifungal treatment and outcome 4
weeks after the onset of infection were collected.
Results: All patients except 16.3 % were adults >18 years old. Majority of patients were
hospitalized on ICU (59.7%); 43.4% of patients had cancer and 16.3 % had haematological
malignancy. 20 % of patients were neutropenic at the onset of candidaemia. Previous
antibacterial treatment (93.4%), inserted central venous catheter (83.6%), total parenteral
nutrition (55.4%), surgical procedure (52%) and colonisation with Candida spp. were the most
common risk factors associated with candidaemia. Fluconazole was the preferred 1st line drug
(58.6% of all treated patients) followed by Voriconazole (18.4%) and Amphotericin B (10.8%). 6
patients (6.5%) did not receive any antifungal therapy - 2/6 died and 4/6 survived.
Fungaemia-related and candidaemia-related mortality was 33.7% and 27.2 %, respectively. 16/25
(64%) deaths were due to candidaemia caused by non-albicans candida strains and 9/25 (36%)
were associated with C.albicans.
Conclusion: Mortality of patients with candidaemia reflects the epidemiological trend in Slovakia
where majority of cases are caused by non-albicans strains. The choice of antifungal therapy
should be in concordance with epidemiological data.