14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 28.014 Session: Influenza Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Development of new effective antiinfluenza drugs based on extracts of basidiomycetes A. Kabanov, A. O. Sementsova, M. O. Skarnovich, T. V. Teplyakova, L. N. Shishkina , A. N. Sergeev FSRI State research center of virology and biotechnology "Vector" , Novosibirsk, Russian Federation Background: Due to the high incidence of respiratory diseases in humans caused by influenza viruses of different subtypes are now particularly relevant search for new curative and preventive drugs against influenza. Many species and strains of basidiomycetes are producers of natural compounds exhibiting anti-tumor and antiblastic activity, cytostatic effect and antiviral effect. Specific components of different bio-genetic origin, with antibacterial, anti-fungal, nematodocidal, cytotoxic, antiviral, and other pharmacological properties of the basidiomycetes were identified in different investigations. Study of antiviral activity of extracts isolated from basidiomycetes against influenza virus, including highly pathogenic avian influenza and creation on their basis of new non-toxic antiviral drugs is essential for health. In the present investigation was carried out screening and studying of antiviral activity of basidiomycete extracts in experiments on MDCK cells for avian influenza A/H5N1 virus. Methods: In present study more than 70 water extracts of fungi of the genera Rleurotus, Ganoderma, Laetiporus, Inonotus, Lentipus obtained from the laboratory collection of fungal cultures and the simplest of SRC VB "Vector" were used. The antiviral effect of extracts of fungi was assessed by highly pathogenic avian influenza A/chicken/Kurgan/05/2005 (H5N1) virus strain and MDCK cells. Results: The results showed that many of the studied extracts of basidiomycetes have not toxicity to MDCK cells and thus exhibit a high antiviral efficacy. This fact was noted in the evaluation of A/chicken/Kurgan/05/2005 infectivity in model of MDCK cells, when cultured with influenza virus strain in the presence and absence of tested drugs. Some aqueous extracts of fungi Ganoderma, Laetiporus, Inonotus and Lentipus has been shown in vitro to have high up to 1000- 10000 times neutralization activity for influenza A/chicken/Kurgan/05/2005 virus strain. Conclusion: One possible reason for the effectiveness of the audited extracts isolated from the basidiomycetes is the presence of polysaccharides. The spectrum of polysaccharides, flavonoids, melanins, mycelium and fruit of body and other biologically active substances of basidiomycetes is very wide. The results of the studies of fungi extracts suggest about the great prospects associated with the study of substances from basidiomycetes to create new highly effective antiviral therapeutic preparations on their basis.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 28.015 Session: Influenza Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Multifocal cerebral hemorrhages in H1N1 SOIV influenza patients: Report of 2 cases E. Carvalho Siqueira, L. M. Carvalho valle, A. D. F. Borges, P. S. Gonçalves da Costa Hospital Monte Sinai & Suprema Medical School, Juiz de Fora MG, MG, Brazil Background: Neurological complications of influenza have been scarcely reported possible under-recognized. The full description of clinical forms of the current pandemic influenza is currently underway. Several different neurological syndromes have been associated with influenza but no cases of multi-focal cerebral hemorrhages have been reported so far. The aim of this report is to present 2 cases of multiple focal cerebral hemorrhages in patients with influenza H1N1 pandemic. Methods: Clinical, laboratorial and imaging data of 2 cases of influenza and serious neurological symptoms are presented. Cranial CT scan was performed in both cases. Influenza virus identification in upper respiratory secretion (UPS) was performed by real-time-reversetranscriptase-polymerase-chain-reaction assay. Cerebrospinal fluid (CSF) was analized. No necropsy or brain biopsy were performed Results: Case nº 1: 32 years old pregnant woman with flu like symptoms, evolved to severe pneumonia and ARDS requiring mechanical ventilation. She developed comma and cranial CT scan has shown multiple hemorrhagic foci scattered throughout the brain and sub-aracnoid hemorrhage (SAH) (Figure 1). CSF was hemorrhagic. No hemorrhagic disorder was found and eclampsia was ruled-out. Despite oseltamivir therapy she eventually died. H1N1 SOIV was isolated from UPS. Case nº 2: 51 years old male with flu like symptoms evolved to ARDS and respiratory insufficiency demanding ICU and mechanical ventilation. He developed status epilepticus. Cranial CT scan showed multifocal hemorrhages. Lumbar CSF was hemorrhagic. H1N1 SOIV was isolated from UPS. Despite therapy with oseltamivir he eventually died. Figure 1: Cranial CT scan showing multifocal hemorrhage in frontal, parietal, temporal and occipital lobes, as well as SAH and intraventricular hemorrhage Conclusion: Influenza has imposed an under-recognized burden of central nervous system disease so far. Well known neurological syndromes associated with influenza virus in humans have been febrile convulsions, acute encephalitis, acute encephalopathy, Reye’s syndrome, Guillain-Barré syndrome, Kleine-Levin syndrome and post encephalitic Parkinson’s disease. Some encephalitis cases with petechial lesions in the brain have also been reported. The highly pathogenic H5N1 influenza virus has shown neurological damage in both birds and humans. Current medical literature, including some up-to-date publications of H1N1 pandemic haven’t shown the occurrence of multifocal hemorrhagic neurological syndromes. The cases here presented should aware practitioners for such possibility especially because many seriously ill influenza patients in ICU have been kept under sedation so hiding several neurological symptoms.
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