14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 30.021 Session: Mycology, Fungal Infections and Antifungal Drugs Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Prevalence of Cryptococcal meningitis among HIV seropositive patients in Georgia L. Gatserelia, L. Sharvadze, M. Karchava, L. Dzigua, N. Dvali, N. Badridze, T. Tsertsvadze Infectious Diseases, AIDS and Clinical Immunology Research Center, Tbilisi, Georgia Background: Cryptococcal meningitis is a frequently observed opportunistic fungal infection in HIV seropositive patients in Georgia and an important cause of mortality among these patients. This study estimates the prevalence of cryptococcal disease in Georgia in 2003- 2008 among human immunodeficiency virus (HIV)-infected patients who were at risk. Methods: Numerator data were generated by surveying all HIV infected patients in Georgia during 2003- 2008 years. A routine serum cryptococcal antigen screening was performed on 920 HIV-positive/AIDS patients by ELISA (Premier Meridian, Italy) to improve the prognosis of cryptococcal meningitis in HIV-infected patients through earlier diagnosis. The cerebrospinal fluid (CSF) samples were processed for ELISA testing after preliminary microscopic examination, comprising wet mount, Indian ink. Results: Cryptococcal antigen was detected in the sera of 103 (11.2%) of them. Cerebrospinal fluid was obtained from 98 of these 103 patients and the presence of Cryptococcus neoformans was demonstrated by direct microscopy in 64 (66%) of them. This represents 7% of the originally screened HIV seropositive group. The incidence of cryptococcal isolation was in the 30-45 age group and predominantly affected were male patients (59 from 64). Conclusion: In Georgia prevalence of Cryptococcal meningitis among HIV seropositive patients is about 7%. We found some relationship between age, gender and prevalence of Cryptococcal meningitis among HIV infected patients. The routine mycological surveillance is required for HIV/AIDS patients to help in an early diagnosis and appropriate therapy.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 30.022 Session: Mycology, Fungal Infections and Antifungal Drugs Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Clinical analysis of 92 patients with Fungaemia - data from national survey in Slovakia L. Drgona 1 , J. Trupl 2 , H. Hupkova 3 1 Comenius University and National Cancer Institute , Bratislava, Slovakia, 2 AlphaMedical s.r.o., Bratislava, Slovakia, 3 Comenius University, Bratislava, Slovakia Background: A prospective national survey on fungaemia was done during 2005-2007 in Slovakia. The increasing incidence of fungaemia and candidaemia was documented (2.57 and 2.16/100.000/year, respectively) comparing previous survey. 38% of cases of candidaemia were caused by C. albicans and 62% by non-albicans strains. Methods: 92 episodes in 92 patients with fungaemia and available clinical data were analysed according to data from CRFs. Informations about risk factors, antifungal treatment and outcome 4 weeks after the onset of infection were collected. Results: All patients except 16.3 % were adults >18 years old. Majority of patients were hospitalized on ICU (59.7%); 43.4% of patients had cancer and 16.3 % had haematological malignancy. 20 % of patients were neutropenic at the onset of candidaemia. Previous antibacterial treatment (93.4%), inserted central venous catheter (83.6%), total parenteral nutrition (55.4%), surgical procedure (52%) and colonisation with Candida spp. were the most common risk factors associated with candidaemia. Fluconazole was the preferred 1st line drug (58.6% of all treated patients) followed by Voriconazole (18.4%) and Amphotericin B (10.8%). 6 patients (6.5%) did not receive any antifungal therapy - 2/6 died and 4/6 survived. Fungaemia-related and candidaemia-related mortality was 33.7% and 27.2 %, respectively. 16/25 (64%) deaths were due to candidaemia caused by non-albicans candida strains and 9/25 (36%) were associated with C.albicans. Conclusion: Mortality of patients with candidaemia reflects the epidemiological trend in Slovakia where majority of cases are caused by non-albicans strains. The choice of antifungal therapy should be in concordance with epidemiological data.
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