14th ICID - Poster Abstracts - International Society for Infectious ...

When citing these abstracts please use the following reference:
Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number.
Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1
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Final Abstract Number: 27.001
Session: HIV: Epidemiology and Prevention
Date: Wednesday, March 10, 2010
Time: 12:30-13:30
Room: Poster & Exhibition Area/Ground Level
Type: Poster Presentation
The vertical transmission of the HIV/AIDS. 22 years of experience in Cuba
I. González Nuñez
Instituto de Medicina Tropical Pedro Kouri, Ciudad De La Habana, Cuba
Background: Since 1986 a controlled program was established in the primary health care
system in order to reduce vertical transmission in Cuba.
Methods: The usual approach followed with each HIV+ pregnant woman who decides to keep
her pregnancy, is to administer HAART independently her immunologic status, from week 14 to
the time when a caesarean operation is carried out (week 38). Maternal nursing is strongly
discouraged. The newborn child receives ZDV (2mg/Kg/dose) every 6 hours for the first 6 weeks.
The children are followed-up in IPK outpatient office, where their HIV infection status is
determined. Infected children are treated with antiretrovirals according to the presence of
opportunistic diseases, CD4 cell count and viral load. Quantification of CD4 is determined by flow
cytometry, using a FACScan cytometer. Quantification of viral RNA levels was made with the
Nuclisens system from Biomerieux.
Results: A total of 2074 seropositive women have been reported between January 1st, 1986 and
December 2008 of all the seropositive cases (10655) reported for the country (19.4%). Threehundred
thirty and seven seropositive women (16,2%) have given birth to a total of 364 children
(22 women have delivered twice and 5 women have delivered twins); of the 364 children 35
(9,6%) are HIV+ , 33 (33/35=94,2%) have been classified as AIDS patients, 21(21/35=60.0%) are
under treatment with HAART ; 3 (3/35=8,5%) are asymptomatic and 11(11/35=31,4 %) have died.
No infection has been shown in 255 children (255/364=70,0%) by PCR and Western Blot, and 74
(74/364=20,3%) are still under study.
Conclusion: The Program of Prevention and Control of Vertical transmission is effective since
the number of infected children is low, similar to the figures reported for developed countries.