14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 28.010 Session: Influenza Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Influenza in the tropics - Epidemiology and burden L. Da Silva, M. H. Kyaw Novartis Vaccines and Diagnostics, Cambridge, MA, USA Background: Although influenza presents a significant burden in the tropics, the belief that this disease primarily affects people in temperate climates and developed countries persists because of peculiar circumstances of disease epidemiology, other local causes of morbidity and mortality, and better surveillance systems in countries in temperate regions. The public health burden of influenza is high in the tropics, particularly in children, yet it has been suggested that vaccination programs would not be cost-effective in this region because little is known about the true impact of the disease. Methods: Systematic literature review of Medline using search terms of influenza, tropical, and epidemiology. Results: In Medline, 155 manuscripts were published between 1969 and 2009. Influenza in tropical regions has gained more attention in the medical literature in the twenty-first century; 118 of 155 papers (76%) appeared after 1999. Twenty-three studies presented data on laboratoryconfirmed cases of influenza in tropical regions. Outbreaks and epidemics present a significant public health burden in tropical regions. For example, in Madagascar in 2002, more than 27,000 cases of influenza and 800 deaths occurred within a period of three months despite rapid public health intervention. In tropical regions, viral transmission is usually year-round and commonly has two peaks annually. Co-circulation of what are considered “northern” or “southern” strains occurs year-round in tropical regions. Tropical regions, thus, may be the source of new strains that are then disseminated to other latitudes. However, the clinical characteristics, impact on healthcare services, and seasonal variation of influenza in tropical regions are still not clearly understood, based on the current literature. A third category of strain recommendation for influenza vaccines may be needed for tropical regions. Conclusion: The burden of influenza in tropical countries may be higher than in North America or Europe. More studies in the tropics are necessary to define the impact and seasonality of influenza in these regions. These data could help identify the optimal timing of vaccination programs and other measures for the prevention and control of seasonal and pandemic influenza in the tropics, including protection for travelers and control of emerging strains.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 28.011 Session: Influenza Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Novel influenza A H1N1 (NIA) infection in Argentinean Children – Experience at Hospital de Niños “Ricardo Gutiérrez” E. L. Lopez, A. FALLO, M. M. Contrini, A. Mistchenko , C. Molise, S. Neyro, N. Gonzalez, D. Lazzarini, G. Manonelles, J. Grichener, M. Dastugue, A. Teper, N. Study Group Hospital de Niños "Ricardo Gutiérrez", Buenos Aires, Argentina Background: NIA pandemia (P) began in Argentina during respiratory virus season. Hospital Gutiérrez (HG) set up special outfitted examination room trailler; 5000 suspected cases were attended in 2 mo. Health care for P included 2 different stages: May24-June12, 695 outpatients mainly school-age were attended [Containment Phase(CP)]. After 17 ds with a widespread disease: June12-July11, 110 children were admitted to HG due to respiratory failure [Mitigation Phase(MP)] Objective to characterize clinical, lab and treatment of confirmed NIA patients (pts) Methods: IFA was used to rule out other RV; confirmation by RT-PCR Results: CP: 220/695(61.3%) cases were confirmed; 191students, 15 close contacts (CC), 8 international travelers, 3 teachers; 2 health-workers. The 191 confirmed student cases are reported: mean age: 9±3(4-17) yr; 16(8%) had comorbidity(C). Most frequent symptoms: fever(F) 178(93%) and cough(Co)160(64%). Oseltamivir(Os) was prescribed to 150(78.5%); none of them was hospitalized. Duration of F and Co was lower in treated than untreated 2,1 vs 3.6 ds, and 4.2 vs 7 ds respectively(p24 mo: 38/61(62.3%) than younger 46/49(93.9%)(p
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