14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 30.001 Session: Mycology, Fungal Infections and Antifungal Drugs Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Candida species in the lower respiratory tract of healthy individuals H. J. Salzer 1 , R. B. Raggam 2 , I. Zollner-Schwetz 1 , M. Hoenigl 1 , T. Valentin 1 , R. Krause 1 1 Medical University of Graz, Graz, Austria, 2 University Hospital Graz, Graz, Austria Background: Candida species (spp.) are frequently isolated from respiratory tract secretions such as endotracheal aspirates (EA) in patients with pulmonary infiltrates. Since the prevalence of Candida spp. in the lower respiratory tract is unknown in healthy individuals the pathogenetic relevance of Candida spp. in the lower respiratory tract is difficult to assess. Methods: A total of 71 healthy individuals without clinical, laboratory or radiological evidence of respiratory tract infections (temperature >38°C, elevated CRP >8mg/dl, leukocytosis >11400, elevated neutrophiles) or any other lung diseases (e.g. COPD, asthma bronchiale, sarcoidosis, interstitial lung disease, malignant diseases of the lung) undergoing general anaesthesia due to elective surgery were enrolled. Exclusion criteria included antifungal therapy within 8 weeks and antimicrobial therapy within 4 weeks prior to study inclusion (with the exception of antimicrobial surgical prophylaxis), immunosuppressive therapy, active haematooncological diseases and HIV positivity. The presence of Candida spp. in the lower respiratory tract was investigated in EA samples cultivated on Candida CHROMagar. The Candida colonies were differentiated as C. albicans, C. glabrata, C. krusei, C. tropicalis or others according to the color of colonies and by API Aux test. For bacterial growth EA samples were further cultivated on selective agars. Bacterial cultures are counted and identified by routine microbiological procedures. In addition, oral swabs were obtained and cultured on Candida CHROMagar. Results: A total of 88 microorganisms were isolated from 41 of the 71 EA samples containing 1 yeast (C. krusei), 62 gram-positive and 25 gram-negative bacterial species including the indigenous oral flora. In 30 EA samples neither bacteria nor fungi were cultured. A total of 24 Candida spp. were isolated from 21 of the 71 oral swabs containing 18 C. albicans, 2 C. glabrata and 1 C. krusei isolates. In addition, C. krusei isolated from both EA sample and oral cavity was originated within the same patient. Conclusion: The colonization of the lower respiratory tract with Candida spp. in healthy individuals seems to be uncommon, despite a relative frequent Candida spp. colonization of the oral cavity.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 30.002 Session: Mycology, Fungal Infections and Antifungal Drugs Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Influence of gender, age, previous hospitalization and hospital stay on Candida-colonization of patients in a non-surgical ICU A. Gloeckner 1 , P. Abel 2 1 BDH-Klinik Greifswald, Greifswald, Germany, 2 University of Greifswald, Greifswald, Germany Background: The incidence of systemic fungal infections is increasing and their mortality remains high despite all advances in therapy. Accurate diagnostic measures are still difficult to obtain and evaluate in order to determine the need for antifungal treatment. Moreover, Candida species differ substantially in their antimycotic susceptibility. Thus knowledge of species to be expected is crucial for not missing the diagnosis and making the right decision how to treat. Methods: In a prospective study over 30 month we analysed samples from 411 patients (160 women and 251 men, mean age 63.6 years, mean APACHE-II-Score 20.8) admitted to our ICU. Swabs from nostril, throat and anus and specimens of tracheal secretions and urine were taken and cultured on CHROM- or CandID- Agar at 36°C. The hospitalization history of the patients was investigated. Results: Positive results were found in 43% of all 1868 investigated samples. Concerning the distribution of species, we found Candida albicans in 69%, Candida glabrata in 35% and Candida tropicalis in 8% of all positive specimens. The colonization index was higher in women than in men (mean 0.47 vs. 0.39, p
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