14th ICID - Poster Abstracts - International Society for Infectious ...

When citing these abstracts please use the following reference:
Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number.
Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1
is available electronically on http://www.sciencedirect.com
Final Abstract Number: 23.029
Session: Antibiotic Resistance Gram-Negative
Date: Wednesday, March 10, 2010
Time: 12:30-13:30
Room: Poster & Exhibition Area/Ground Level
Type: Poster Presentation
Clinical characterization of patients with carbapenem-resistant versus carbapenem-susceptible
Acinetobacter baumannii infections
I. Tyagi, J. Koirala
Southern Illinois University School of Medicine, Springfield, IL, USA
Background:
Steady rise in carbapenem resistance in Acinetobacter baumannii has become a major challenge
for clinicians. The objective of this study is to characterize clinical features of infections secondary
to carbapenem-resistant organisms compared to carbapenem-susceptible organisms.
Methods: We conducted a retrospective analysis of data for 39 patients from two tertiary care
medical centers who had positive cultures for A. baumannii. Collected data included clinical
presentations, underlying illnesses, treatment course, clinical outcome, microbiological data and
other laboratory data. Statistical comparisons were done between patients infected with
carbapenem-resistant (CRAB) and carbapenem-susceptible (CSAB) isolates using Fisher’s exact
test and Student’s T-test. Multidrug resistance (MDR) was defined as resistance to more than two
classes of antibiotics generally active against A. baumannii.
Results:
Total 17 (44%) patients had carbapenem-resistant (CRAB) and 24 (62%) had multidrug resistant
(MDR) A. baumannii. Mean age (53±5.7 years) and male predominance (70%) were comparable
in both groups. Predisposing factors included diabetes mellitus (15), pressure ulcers (12),
malignancy (8), paraplegia (7), burn (5), peripheral vascular disease (5), and chronic renal failure
(5). Majority of the infections involved wound (13) and bone (10) followed by sputum (8), urine (5)
and bloodstream (3). Mean duration for first positive A. baumannii cultures after admission to the
hospital was 6.6 (±3.4) days. Patients infected with CRAB had significantly higher rates of
respiratory or other organ failures (47% vs. 14%, p